On April 4th, Zohreh Shiamizadeh succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Zohreh on this great result.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Learning analytics tracks students’ online learning activities in order to support their learning. But what if most of their learning takes place offline, out of sight of digital eyes?

This thesis discusses the discovery potential of Intensity Frontier experiments.

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This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

On 3 December 2019, Hanna Bosdriesz defended her thesis 'Furthering the fight against impunity in Latin America: the contributions of the Inter-American Court of Human Rights to domestic accountability processes'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. M.A.H. van…

The proportion of children who are overweight has increased enormously over the past 20 years. The number has currently stabilised but even so there are still too many overweight and obese children. Could there be some connection with the way they are brought up? Roxanna Camfferman's PhD research shows…

With regard to governance, policies and law, many Muslims and Muslim countries recognise the possibility that Islam has something important to say about the way society is to be ordered, governed, and regulated.

Below you can find information about the research projects on public leadership of the public management research group at the Institute of Public Administration.

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

How politically sensitive cases affect public trust in judges

Research conducted by Dutch news programme ‘Nieuwsuur’ into the work carried out by Princess Laurentien of the Netherlands for victims of the childcare benefits scandal raises many questions. Legal experts are puzzled as to how the Cabinet at the time assigned the tasks. Geerten Boogaard, Professor…

Students from Leiden University have launched The Nuance Project, a platform for respectful, open-minded dialogue on divisive issues. The aim is to foster connection and understanding among people even if their viewpoints differ.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: T. H. Oosterkamp

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotores: G.W. Canters, T.J. Aartsma

PhD defence

It’s not a regular occurrence at Leiden University: two professors giving their inaugural lecture on the same day. Berna Güroğlu and Ellen de Bruijn specialise in related disciplines: they both research the influence of social context on processes in the brain – Güroğlu in adolescents and De Bruijn…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Making sensitive data reusable through synthetic data generation

How many children are born with the help of a surrogate mother in the Netherlands, and which legal obstacles can arise? Through a new interdisciplinary study, researchers at Leiden University are attempting to provide clarity about surrogacy processes.

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