PhD defence

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

PhD defence

From March 14 to 16, 2018 Prof. mr. dr. Maartje van der Woude organized an international seminar and PhD masterclass on the topic of “Transformative Borders and the Politics of Migration in Western Liberal Democracies”. Both events were organized as part of Prof. Van der Woude’s NWO VIDI Grant “Getting…

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

Over the next three years, 92 students and researchers from Leiden University and its partner universities will be strengthening their research and teaching links: all 14 projects that Leiden University submitted to the EU’s International Credit Mobility programme have been awarded a grant. Three ex…

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Unravelling networks of human mobility and exchange of goods and ideas from a pre-colonial, pan-Caribbean perspective

Promotor: Prof.dr. G.P. van Wezel

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Prof.dr. J. Kuiper

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

The aim of this project is to gain a better understanding of daily life, diet, mobility and health in late medieval Zeeland, as well as to test the potential of multi-isotopic analyses on a Dutch assemblage.

Have you got an old mobile phone lying around? If so, you can hand it in at Funky Phone in Lipsius. The phone will be recycled and you get to play an old-fashioned arcade game on the Funky Phone games computer built from discarded electronics. Vice-Rector Hester Bijl kicked off the Funky Phone Challenge…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

An inter-university conference will take place at the University of Namur, from 10-12 April 2024. Young researchers working on mobility & interactions in the Meuse-Rhine region between the ninth and fifteenth centuries are encouraged to submit abstracts of max. 500 words before November 1.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

A more efficient solar panel sounds great. But what if these new panels consume more toxic materials, or their production consumes a lot of energy? Leiden environmental scientists, together with colleagues from the Fraunhofer ISE, address this multifaceted question in a new publication in the prestigious…

Peter Slort is the highly driven portfolio holder for Diversity with the Dutch National Police. Since November 2016 he has been spreading the importance of diversity throughout the police organisation.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

How did persistent social inequalities first emerge? What cultural trajectories and institutions made this key development possible? How can archaeological inform us about the formation of class societies?

In this project we think about the relationship between territory and contagion. Tracing the historical, political, and conceptual linkages between territorial bordering and migration on the one hand and disease related phenomena like contagion, immunity, and inoculation on the other, we ask how the…