A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Our language is adapted to the context in which we humans communicate. But computers ‘think’ differently. What would a language be like whose structure was optimally adjusted for use by humans and machines? Tessa Verhoef is trying to find the answer.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

The studies reported in this thesis were situated in the context of an innovation of Dutch secondary school biology curricula. As in any innovation, the practical knowledge of teachers determine the outcomes through the decisions they make while planning and teaching their lessons. The aim of the studies…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

A mix of data research, artificial intelligence and archaeology led to lively discussions on 31 January. On that day the unique event 'AI & Data Science @ Archaeology' took place in which the Data Science Research Programme (DSRP), SAILS and the Faculty of Archaeology joined forces.

There are millions of gene clusters that encode the biosynthesis of bioactive natural products, with the vast majority yet unknown. How can we prioritize them to discover new chemical space for antibiotics? For this we will set up a pipeline based on federated learning (AI), synthetic biology and bioactivity…

A collaboration of physicists and chemists organized the LEELIS conference on new computer chip technology in Amsterdam on 10-11 November. Leiden physicist Joost Frenken is director of the organizing institute ARCNL.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Over the past decade, several novel types of spatially resolved

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

A piece of corrugated rubber can function as a simple computer, displaying memory and displaying the ability to count to two. Leiden physicists describe the computing rubber in the journal PNAS. ‘Simple materials can process information, and we want to find the principles behind that.’

Master Computer Science in Leiden nr.1 according to Elsevier

The worldwide race to the quantum computer is in full swing. This computer can bring about a breakthrough in discovering medicines and new materials. Leiden researchers, together with the TU Delft, are taking part in the race. There is now a dossier online about their work.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

American physicist and quantum computing pioneer Seth Lloyd is the 65th Lorentz professor. He will deliver the Ehrenfest lecture on 5 June, and several more lectures on quantum computing on 11, 18 and 25 June.

Leiden University and the Beijing Institute of Technology will be collaborating in the area of computer science teaching and research. One of the first outcomes of this collaboration will be a joint four-year bachelor's programme. Willem te Beest, Vice-President of the Executive Board, and Professor…

An international committee has assessed computer science research at all Dutch universities in the period 2009-2014. For its computer science research, Leiden was awarded the ‘highest’ mark (1) for relevance to society.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Leiden prof. emeritus Grzegorz Rozenberg is honoured with the first life time award in formal languages, a research area of theoretical computer science. During a small ceremony at his house, he received a statue that was specially made for the occasion.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…