2,460 search results for “een lacdr” in the Public website
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Characterization of Cell-based medicinal products (CBMPs)
Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…
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Peptide Amphiphile Nanoparticles Enhance the Immune Response Against a CpG-Adjuvanted Influenza Antigen
Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Teaching
As part of your assignment you are required to contribute to teaching in the Bachelor and the Master programs in Bio-Pharmaceutical Sciences of Leiden University. You will supervise Bachelor and Master students during the research projects of the students in the laboratory.
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Information activities
Get to know us through our online and in-person events for prospective students!
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Information activities
Get to know us through our online and in-person events for prospective students!
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Master's application and admission
Find out how to apply for Bio-Pharmaceutical Sciences and Education at Leiden University by following our step-by-step guide.
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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Master's application and admission
Find out how to apply for Bio-Pharmaceutical Sciences and Business Studies at Leiden University by following our step-by-step guide.
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Information activities
Get to know us through our online and in-person events for prospective students!
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Information activities
Get to know us through our online and in-person events for prospective students!
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Master's application and admission
Find out how to apply for Research in Bio-Pharmaceutical Sciences at Leiden University by following our step-by-step guide.
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Master's application and admission
Find out how to apply for Bio-Pharmaceutical Sciences and Science Communication and Society at Leiden University by following our step-by-step guide.
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Master's application and admission
Find out how to apply for Bio-Pharmaceutical Sciences at Leiden University by following our step-by-step guide.
-
Information activities
Get to know us through our online and in-person events for prospective students!
-
Information activities
Get to know us through our online and in-person events for prospective students!
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Rob van der Heijden
PhD at Leiden University and Bruker - the Netherlands
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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Programme structure
Connect theory and practice of teaching through the application of your academic knowledge about chemistry to issues of classroom practice.
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LED3 PhD/Postdoc Symposium
Conference
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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BRCA1-associated breast cancer: finding new weapons for an old villain
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Reduced stratum corneum lipid chain length relates to an impaired skin barrier function in patients with atopic dermatitis
Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963
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Microfluidics for high-throughput liposome formulation for personalized cancer vaccination
Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…
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Next Generation ImmunoDermatology project
The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile the immune-mediated inflammatory diseases: i) atopic dermatitis (AD), ii) cutaneous lupus erythematosus (CLE) iii) chronic spontaneous urticaria (CSU) iv) hidradenitis suppurativa (HS) v)…
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Lipid chain length reduction correlates with the skin barrier function in atopic eczema patients and inflammation plays a role in the altered
Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)
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The role of lipids in the barrier function of the skin
The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…
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Development of an intradermal tuberculosis vaccine by combining dissolvable microneedle arrays and Mycobacterium tuberculosis antigen-containing
Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…
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Patient Remote Monitoring in Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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Development of an effective, safe, and painless intradermal tuberculosis vaccine based on microneedles loaded with antigen-containing nanoparticles
Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…
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Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays
Source: The AAPS journal, Volume 16, Issue 4, pp. 681-684 (2014)
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Central role of Claudin-1 in lesional but not in non-lesional atopic dermatitis
Source: Journal of Investigative Dermatology, Volume 134, pp. S44-S44 (2014) ISBN: 0022-202X
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Design of dissolvable microneedles for intradermal TB vaccination
Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…
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Flitsinterview met alumnus Kees van der Staaij: ik ben en blijf een jurist in hart en nieren
Flitsinterview met alumnus Kees van der Staaij: ik ben en blijf een jurist in hart en nieren
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het woord: ‘Ik ben er dit jaar ook echt achter gekomen hoe belangrijk een goede ‘work-life-balance’ is’
Deze week sluiten we het academisch jaar af met verschillende FGGA-studenten, waarin zij hun zomer- en toekomstplannen vertellen, maar ook terugblikken op het afgelopen jaar: ‘Ik vond het ontzettend prettig om weer terug te komen naar de fijne sfeer op Wijnhaven.’
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Een wetenschap van verbondenheid
Inaugural lecture
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Zoonímia Histórico-comparativa: Denominações dos antílopes em bantu
On the 26th of February, Joane de Lima Santiago successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Joane on this achievement.
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Dutch Research Council Open Science Fund grants for five Leiden projects
Five projects with a lead applicant from Leiden will receive an Open Science Fund grant from the Dutch Research Council (NWO).
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Thunderstorm: A small cultural history (1752-1830) (in Dutch)
More on the Dutch webpage.
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It began with William of Orange
Leiden University was founded in 1575, thanks to William of Orange. According to tradition, he founded the University to reward the citizens of Leiden for their resistance to the Spanish occupiers.
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Optimal Test Statistics for Anytime-Valid Hypothesis Tests
Vandaag de dag liggen statistische methodes aan de grondslag van beslissingen in allerlei facetten van het leven, van de gezondheidszorg en agricultuur tot de financiële sector en marketing.
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Under Construction. Cognitive and Computational Aspects of Extended Lexical Units
This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.