This study presents an agent-based simulation model exploring the patterns of presence and absence of Late Pleistocene Neanderthals in western Europe.

Data theory research on the analysis on the multidimensional data

How do we address the pressing challenges posed by large-scale networks?

Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

The programme group Parenting, Child Care and Development studies how parents and other educators affect children's development, well-being and health. The emphasis is on the child's social, emotional and cognitive development and prevention of problems in these areas.

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

If you can't make it to Leiden University to visit us, don't worry. Our virtual tours take you around the cities of Leiden and The Hague, show you around on campus and into our classrooms.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Many head teachers will have to try and fill staffing gaps this summer. Assistant Professor Kim Stroet, who is researching pupil motivation, is worried about the teacher shortage in the Netherlands, but can see a development that may help solve it.

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

A neural network mimics how our brain works. Evolutionary algorithms use the principle of natural selection to solve complex problems. This kind of 'natural computing' is being used to improve the diagnosis of Parkinson's disease or the production of steel.

When to launch a next-generation product in a competitive market and how much capacity should be allocated to it

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

The research programme Probability Theory focuses on probability theory and on operations research.

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Promotor: H.J.M. de Groot

Researchers have the whole world as their work area. Dutch researchers collaborate with Chinese, Australians give lectures in Lithuania, Koreans move to America and back. Who can contribute to academic knowledge, who benefits from it and who pays for it? A fair and effective system for this has not…

While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…

Urban, Food, Water, Biodiversity, Resources and Energy: these are the main research topics of the Institute of Environmental Sciences. We always strive to be a global leader in our field. And make a real impact with both our research programmes.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

With the knowledge, tools and practical experience you will have obtained as a graduate of the master’s specialisation Parenting and Child Development, you will be able to effectively contribute to promoting optimal caregiving and child development.

Leiden Institute of Advanced Computer Science (LIACS)

What if you could watch a CT scan live, instead of analysing the images afterwards? If it is up to the Leiden mathematician Jan-Willem Buurlage, that will soon be a reality. He is developing methods to make the algorithms behind 3D scans faster. Quite a challenge: ‘Just like mathematicians, computers…

What is 'teaching excellence' in Higher Education? Which different teaching excellence training, promotion and reward schemes exist across Europe? How can a common European teaching scheme look like? The e-NOTE project led by Leiden University seeks to answer these question in cooperation with five…

GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).

Sustainable energy from wind and solar is most readily available near the sea.

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotores: J. Jonkers, K.E. de Visser

IBL researchers use the facility to study a wide range of wildtype and transgenic plants, including Arabidopsis, tomato, barley, rice, lettuce, radish, ornamentals, and various trees. Research also involves the interaction between plants and various microorganisms and insects, providing valuable insights…

Promotor: Prof.dr. K.J. Batenburg

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

Edited by linguists Jenny Audring (Leiden University) and Francesca Masini (University of Bologna), this is a unique handbook with a focus on morphology theories rather than morphological data. It covers a wide array of morphological theories, from traditional twentieth century models to current theoretical…

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen