Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

A selection of recent publications from the Plant BioDynamics Laboratory.

What is a good data protection law? How does a good data protection law evolve? Is European data protection law a good one? And whether the European data protection applicable to China?

Promotor: Prof.dr. G.P. van Wezel

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

In what way did Hellenistic legal institutions concerning secured credit influence Roman law?

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Promotor: Prof.dr. J. Kuiper

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Key publications of the Cancer Drug Target Discovery group

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

An overview of research themes and projects at ABS.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…

Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

An overview of the research at the Cancer Dug Target Discovery group.

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…