Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Assistant professor and dual PhD candidate, Pieter Slaman writes in Binnenlands Bestuur about the fact that the German occupier lengthened the period of mandatory education in The Netherlands.

Promotor: Prof.dr. S.F. Portegies Zwart

The Leiden University doctoral / PhD programme takes around four years of study and consists of independent and original research under the supervision of a professor.

What is the effect of transgovernmental networks on the principles and practices of democratic accountability within national central governments?

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Introductory courses, Seminars and Minor Economics and Dual Programs

This monograph, written by dr. Dennie Oude Nijhuis and published by Cambridge University Press, discusses the postwar development of the welfare state.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Tapping to a rhythm, recognizing sound patterns and enjoying music: For people, it is common sense. But is this also the case for animals? It is the research topic of Michelle Spierings, a researcher at the Institute of Biology Leiden, and it is nominated for the Klokhuis Wetenschapsprijs.

Birds around airports are more aggressive and sing as if they have hearing loss. Collaboration between researchers of Manchester Metropolitan University and the Institute of Biology Leiden has led to surprising new findings about the impact of anthropogenic noise on birds around airports. Publication…

Fishes rely heavily on sound to find their way during migration or dispersal. Many species are affected by noise pollution. Hans Slabbekoorn from the Institute of Biology Leiden received a HORIZON2020 grant of 500,000 euros to study the impact of sound conditions on movement decisions of fishes.

Master's student Thalia Luden receives an NWO grant for her research proposal about a gene that brings flowering plants back into a growth phase. Companies in floriculture and vegetable seed breeding also contribute to the research.

‘It was a discovery we did not expect,’ says Remko Offringa, professor of Plant developmental genetics. Today he publishes a new trait of a versatile gene in Current Biology: it makes the difference in plants between herbaceous and woody stem growth. A useful feature to prevent dehydration.

That a parrot can copycat sounds is nothing new. But vocal learning is not common in animals. Researcher Carel ten Cate of the Institute of Biology Leiden (IBL) of Leiden University has now discovered a duck species that can imitate sounds. ‘It started with an obscure reference about an Australian musk…

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Producing offspring of a crop without sowing and that is even bigger than the parent plant. According to Leiden researchers this can be achieved by overstimulating a single gene that rejuvenates cells, including bringing them back to the embryonic phase.

The Faculty of Archaeology at Leiden University is home to many experts on human evolution. The following staff members are part of the Leiden Human Evolution Collective.

We spoke with Mathilde Witkam about her research as a dual PhD candidate at the Dual PhD Centre. Her dissertation is about the effect of open government on public trust. Mathilde: ‘Trust in government ensures that people are more honest in their tax returns; less control saves time and money.’

For a long time, bird song was considered as a typical male trait. But over the last twenty years, research has shown that a lot of female songbirds sing as well. Female scientists turned out to be the key factor in these findings, amongst others from the Institute of Biology Leiden.

A new study carried out by Leiden archaeologists Hadar Ahituv and Amanda Henry, together with international colleagues, reports the identification and analysis of 650 starch grains preserved on basalt percussive tools (anvils and hammerstones) found at an early Middle Pleistocene site in Israel. These…

Paul Brakefield, Professor of Evolutionary Biology at the Institute of Biology in Leiden (IBL) has been awarded an ERC Advanced Grant for his research. He will receive 2.5 million euro to develop his research programme over a period of five years.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: Prof.dr. E.F. van Dishoeck, Co-promotor: S. Bruderer

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, Dr. B.W. Hoeksema