Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Promotor: Prof.dr. G.P. van Wezel

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

These awards honour researchers who turn scientific insight into real-world impact. From master’s students to postdocs, they highlight exceptional work in life sciences, health sciences, biotech, or environmental health sciences with data science at the core. Meet the 2025 winners.

Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Lecture

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

The MSc program Evolutionary Biology focuses on important factors for the evolution of organisms. It prepares you for a research careers at universities, research institutes, or biotechnology sector. It’s also possible to combine training in biological research with training in communication, education…

PhD defence

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Lecture

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Within the MAC our Enabling Analytical Technology team is working to innovate all steps of analytical workflows. This includes developing novel sample preparation modules, creative sample handling methods, automated workflows, and more. Several projects implement the microfluidic principle of segmented…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Source: PLoS ONE, Volume 10, Issue 3 (2015)

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

OSTrails is a Horizon Europe project enhancing how scientific knowledge is managed and assessed through a FAIR, open system. The Dutch pilot, led by SURF and CWTS, focuses on improving machine-actionable Data Management Plans and linking them with scientific knowledge graphs to boost research interoperability…

A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Explore philosophical research and education at the Leiden Institute for Philosophy. Our scholars study knowledge, ethics and existence, connecting classical and contemporary thought.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Key publications of the Barz Lab

PhD at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Aiming to advance the development and deployment of a scalable, safe, and integrated hydrogen infrastructure to support the energy transition.

The

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Promotores: J. Kok, M. Chaudron (Chalmers University)

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Promotores: W. Jiskoot, F. Ossendorp