Promotor: A.P. IJzerman

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotor: K.J. Batenburg

With tomography it is possible to reconstruct the interior of an object without destroying.

Material Culture Studies revolves around the analysis of the cultural biographies of all sorts of material objects from flint axes, to pottery, to houses and monumental structures.

Promotores: K.J. Batenburg, B. Koren

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

How do young people pursue their interests in and across multiple contexts while participating in tailor-made programs in vocational education and training (VET) and social enterprises to regain perspective in school and work?

During the early modern period, many medieval manuscripts were cut up into strips of parchment which were reused to reinforce the bindings of newly printed books. Until recently, these reused pieces of medieval manuscripts only came to light when the early modern book binding was damaged and/or subjected…

Research at the SBC group is comprised of the following research themes:

The arts and science: for years, they were seen as opposite extremes. One calls on emotion and the other on reason. The Academy of Creative and Performing Arts (ACPA) proves that nothing could be further from the truth. ACPA is where the knowledge and expertise of Leiden University and the University…

Management of Impacts on Biodiversity: What are the effects of light pollution from cities and bridges and noise pollution from passing vessels and nearby road traffic on migratory fish passage and spawning in rivers?

An overview of the research at the Cancer Dug Target Discovery group.

Commercial enterprises who want to make use of the expertise and facilities are referred to LAB , the commercial unit responsible for specialized laboratory work.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Working for a top faculty? Discover the vacancies at the Faculty of Science and apply immediately.

Leiden researchers are helping develop safe COVID-19 vaccines.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Bachelor projects are available in

Read on these pages all about the history of Leiden University, the oldest university in the Netherlands. The Academia Lugduna Batava was founded in 1575 and its motto is: Libertatis Praesidium ('Bastion of Freedom').

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

From the microscope to publication, OMERO handles all your images in a secure central repository. You can view, organize, analyze and share your data from anywhere you have internet access. Work with your images from a desktop app (Windows, Mac or Linux), from the web or from 3rd party software. Over…

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

Our AI researchers work closely with other institutions such as Delft University of Technology and Erasmus University.

Up to 50% of individuals with Parkinson's disease develop cognitive impairment over time; this study explores the use of 'practice effects' on neuropsychological tests as an early predictor of cognitive decline.

Practical applications for the reconstruction of the past

Get on your bike… or your tandem, unicycle, electric bike, tricycle, penny-farthing, rickshaw or road bike! We’re going on a bike trip!

The Mesoamerican research group 'Time in Intercultural Context: the indigenous calendars of Mexico and Guatemala' funded by the ERC and directed by prof. dr. Maarten Jansen, met up in Mexico from the 13th until the 23rd of February for a field seminar in the states of Tlaxcala and Hidalgo.

PhD defence

Are you dealing with an educational challenge or would like to explore innovation opportunities? We actively ideate, design, prototype, build, test real-world solutions to transform theoretical ideas into tangible solutions to enhance the educational landscape for the benefit of your students.

The foundation of the ‘Leids Papyrologisch Instituut’ took place on 19 January 1935. Prior to then, the founders – J.C. van Oven (1881-1963, Roman Law), B.A. van Groningen (1894-1987, Greek) and M. David (1898-1986, Legal History) – had already been teaching Greek papyrology at Leiden University.

For the first time, physicists have visualized the ‘melting’ of electrons inside a special class of insulators. It allows electrons to move freely and turns the insulator into a metal and possibly later into a superconductor. Publication in Nature Physics.

Koen Bastiaans and his colleagues discovered a new quantum liquid unlike anything ever seen. They did it by using a technique that can be compared to listening to the sound of raindrops falling on a roof. Publication in Science 29 October.

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…

SALTSWAT -- a project which combines the Spaces for Active Learning & Teaching and the Support wtih Active Teaching -- began in Mid-2019 and is running in pilot until the summer of 2020. The purpose of the project is to find answers to the question of how to systematically accelerate 'active teaching…

We aim to conduct as few animal experiments as possible. We are continually exploring methods to Replace, Reduce, and Refine animal experiments, commonly referred to as the three Rs. Additionally, we assess each study to ensure the implementation of the 3Rs has been maximised. The Animal Welfare Body…

Since 2013, the National Natural History Museum of the Netherlands, Naturalis Biodiversity Center, is unearthing the largest bonebed of the horned dinosaur Triceratops discovered so far. In order to answer questions about sedimentology, taphonomy and palaeobiology, palaeontologists and geologists collaborated…

From self-driving cars to innovative drug development: artificial intelligence (AI) will fundamentally change our lives in many different ways. We study this technology at a deep and fundamental level. And we seek answers to questions about liability and privacy, for example. Our researchers from…