Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Since 2008 every half a year an SBB student starts with an internship for Merck Serono Ventures in Geneva. Head of the company Roel Bulthuis selects and works with the SBB interns and shares his experiences as an employer. He is very pleased.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

PhD defence

PhD defence

PhD defence

PhD defence

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

Promotor: Prof.dr. G.P. van Wezel

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

On Tuesday the 29th of November, the SBB Studentboard organized the third SBB Colloquium Night. Max, Guido, Niek, Yiyu and Dennis presented their internships, five topics covering many facets of the Science Based Business courses.

Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…

Lecture, Com(parative) Syn(tax) Series

In anticipation of future legal reforms on gender-based violence in the Republic of Moldova, Dr Carlotta Rigotti was invited by the United Nations Population Fund to participate in a roundtable discussion on legislative and policy approaches to online and technology-facilitated violence.

Leiden University's professors will be going to elementary schools again to teach about science and research. During the class discovery-based learning will be central. The professors will go to several schools in The Hague. The classes are part of the university's celebration of its 445th birthday…

On Thursday 23 May, Carlotta Rigotti, postdoctoral researcher at eLaw, gave a guest lecture on the regulation of image-based sexual abuse (IBSA) in the European Union at Kyoto University.

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.

The present market regulations make it extremely risky to invest in green energy, and this is impeding the fight against climate change. This is what Oscar Kraan writes in his dissertation. PhD defence on 25 April.

PhD defence

PhD defence

PhD defence

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

As an exchange student, alumna Jessica Ma was already looking for a bridge between statistics and the real world. In Leiden, she gained the experience to follow her interests and, after a few detours, she landed her ideal job with Disney in the United States.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

The International Conference on Artistic Research, organised by the Society for Artistic Research, will take place in The Hague on 28 & 29 April 2016.

This thesis focuses on addressing four research problems in designing embedded streaming systems.