The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Using mathematics to help children with bone cancer. It sounds a little strange, but for statistician Marta Fiocco, it's just her job. She gets a substantial grant from KiKa for it. With that money, she is going to study the effect of chemotherapy adjustments.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Researchers from the Leiden University Medical Center (LUMC) have developed an AI model that accurately predicts the risk of endometrial cancer recurrence.

Thanks in part to the persistence of a Leiden research group, cancer could be detected in the near future with just a single drop of blood. Not only can the diagnosis be determined at an earlier stage, but the blood test is also cheap, fast and patient friendly. The first results of this method seem…

Promotor: B. van de Water

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Researchers at the Leiden Institute of Advanced Computer Science (LIACS) are collaborating on the development of a conversation tool for patients with breast, prostate and skin cancer. The aim is to create a conversation tool that can support cancer patients in their care and help them make decisions.…

Predicting cancer survival with machine learning, that is the aim of a new collaboration between the Mathematical Institute, the European Organisation for Research and Treatment of Cancer (EORTC) in Brussels and Leiden University Medical Center. The focus of this project is to characterise the model…

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

Currently, more than 80% of drugs are used in an off-label manner in critically ill neonates.

Accelerating the development of new cancer medicines by joining forces—that’s the mission of Oncode Accelerator, a Dutch consortium that recently welcomed three Leiden-based PhD candidates. Under the guidance of Gerard van Westen, Marc Boef, Remco van den Broek, and Lucina-May Nollen are exploring how…

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

Media in the Netherlands and abroad reported extensively about the drug research led by Leiden chemist Mario van der Stelt. In this research, Van der Stelt shows which unwanted side-effects a French drug candidate has.

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Professor of Cardiothoracic Surgery, in particular pulmonary surgery, Jerry Braun will give his inaugural lecture on Friday 23 September entitled ‘Out of countless millions’. Braun has been a professor and acting head of the LUMC’s Department of Cardiothoracic Surgery since January 2020. Covid meant…

His article on ‘the War on Drugs’ in Colombia and the Philippines has been in the top five most downloaded articles of Oxford University Press for some time. Now, Assistant Professor Santino Regilme is to receive a NIAS grant to map out the global war on drugs.

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.

Christmas is coming, which means that 'Our Talents and Discoveries 2016' has been distributed. This also means that it is time to vote for the 'Discoverer of the year 2016'. Each of the eight institutes nominated one researcher that excelled in the past year. Who is your favourite?

An overview of research projects at the Predictive Pharmacology group.

Lecture

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

Medical drugs are expensive to make and can have an adverse effect on the environment. Researchers Stefano Cucurachi and Justin Lian have developed a framework to help the healthcare system assess the economic and environmental sustainability of medical compounds.

'We believe that developing a protocol to help people fight cancer is extremely valuable, given that cancer is such a prevalent and devastating disease. If you believe so too, you can support us in realising this mission.' Master's student in Psychology Saskia Heijnen starts crowdfunding to make her…

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

Researchers at Leiden University have demonstrated that tumours can apply mechanical means to attract the blood vessels they need to be able to grow. The team published this discovery on 2 March in Nature Scientific Reports.

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

Lecture

Could we stop cancer cells by cutting off their energy supply? That’s what Dione Blok, a bachelor’s student in Bio-Pharmaceutical Sciences, aimed to find out during her thesis research. She investigated a compound that affects the tumour cells’ energy metabolism. ‘Hopefully, these insights will provide…

PhD defence

An overview of the research at the Cancer Dug Target Discovery group.

Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make software faster and greener, improve cancer detection and reduce anxiety by manipulating the biological…

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

As a prelude to the Night of Discoveries, an Afternoon of Discoveries will be held in Leiden on 21 September for children from the age of eight. Researchers will tell exciting tales and the children will get to do experiments.