What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

How do mycobacteria subvert the defenses of host immune cells?

Promotor: S.M. Verduyn Lunel

‘Violence as a Population Health Problem’ is one of 33 interdisciplinary projects that have been launched thanks to a Kiem grant. The project team will analyse a large patient database to identify links between violence and other health problems. ‘Violence can also be an expression of other factors,’…

The interdisciplinary Kiem project ‘Violence as a Population Health Problem’ has resulted in a plan to apply for a large, yet-to-be-decided research grant. The so-called pressure cooker session at the heart of the project proved very effective.

The European Research Commission (ERC) has awarded Advanced Grants to two Leiden researchers. Joke Meijer will be researching the effect of the biological clock on our health and Carlo Beenakker will be looking for Majorana fermions in superconductors.

Erection problems can have a huge impact on quality of life and health, but current diagnostic methods are painful, uncomfortable and technologically outdated. PhD candidate Evelien Trip has developed a new device that can measure erections more comfortably and painlessly.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.

For more information regarding ongoing research projects, please contact Prof. Miranda van Eck.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.

Liposomes – nano-sized spheres composed of fatty molecules – are very promising for vaccination. Bio-pharmaceutical scientist Naomi Benne discovered that the immune response in animal models can be steered by varying the charge of the liposomes. She obtained her PhD degree on 8 September for this research,…

Getting out and exercising rather than slobbing on the sofa, breathing in fresh air instead of cigarette smoke and grabbing healthy snacks instead of junk food. In a new interdisciplinary Medical Delta programme, researchers are going to investigate how to help people live healthier lives. What are…

Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…

Prof. Andrea Evers is a health psychologist who studies the role of behavioural factors in health and disease. As a Medical Delta Professor, she is now affiliated with Leiden University, TU Delft and Erasmus University. In that position, she conducts research at the intersection of various disciplines.…

More than half of the Indonesian population lives in cities. What does this mean for public health? How sustainable are these megacities? This is the subject of the ‘Urban Transitions’ Summer Academy on West Java. This summer course is also the kick-off for a renewed interdisciplinary partnership…

The Dutch Research Council (NWO) is investing 197 million euros in 11 infrastructure projects that will be of great value to science and society. Leiden University and the Leiden University Medical Center (LUMC) are participating in eight of the eleven proposals.

It sounds futuristic, but it is possible: the creation of miniature organs of patients in order to study them and see how diseases develop and can be treated. This is what researchers from the LUMC, Twente University (UT), UMCG, TU Delft and the Hubrecht Institute hope to achieve in the next ten years…

Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

Nobody is better qualified to tell you what it is like to work at Leiden University than the employees themselves. Watch the videos and meet your future colleagues. They will be happy to share their experiences with you.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…

Eleven Leiden researchers have been awarded a Veni grant by the Dutch Research Council (NWO). The grant will enable them to develop their research ideas for a period of three years.

Assistant Professor Karlsson Linnér, who works at the Department of Economics, is one of the recipients of a Veni grant. His research on the accuracy of preventive genetic testing is a fine example of the intersection of economic science and law.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

Public funding for fundamental research is essential for innovation and the development of new medicines. This is demonstrated by Professor Science Based Business Simcha Jong and his colleague Hsini Huang after studying US federal funding restrictions for stem cell research under President George W.…

On 15 May, the ambassadors of 11 Latin American and Caribbean countries were shown the highlights of research at Leiden University Faculty of Science. Furthermore, Prince Carlos de Bourbon de Parme awarded prizes to two young academics who conduct research in Latin America.

Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.

How do plant defense genes get activated?

A new health programme will reward patients with - or at risk of developing - cardio-vascular diseases for keeping to a healthy lifestyle. A research group including psychologist Andrea Evers has been awarded 2.5 million euros by the Dutch Heart Foundation and the Ministry of Public Health, Welfare…

Three Psychology students will present a poster of their thesis research on Alzheimer’s and dementia at the international conference AAIC Neuroscience Next. ‘I remind myself to recognise - without fear or shame - when I don't know something.’

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.

Researchers, policymakers and funders have to take more account of the effect of sex and gender in scientific research. This is the view presented in an advice paper published by LERU, the League of European Research Universities. The lead author is Vice-Rector Simone Buitendijk.

What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

The objective of the PhD Education and Supervision program is to educate PhD candidates in becoming professionals who are competent to conduct scientific research in the field of the pharmaceutical sciences independently.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua