1,779 search results for “complex systems” in the Public website
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personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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sustainability of NdFeB magnet recycling: foresight study on recycling systems and technologies
The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.
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HomininSpace – a large scale simulation system for hominins in the past
HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems
On 14 November 2019, Luis Fiallos Pazmino defended his thesis 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon and Prof. E.C.P.D.C. De Brabandere.
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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The Chicago system: a steadfast legal blueprint for world civil aviation?
On the occasion of the 80th anniversary of the magna carta of civil aviation, the Convention on International Civil Aviation (Chicago Convention 1944), Professor Steven Truxal has written a leading piece for the European Civil Aviation Conference: The Chicago system: a steadfast legal blueprint for…
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Aysegül ÇelikFaculty of Science
a.celik@cml.leidenuniv.nl | 071 5272727
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Fatemeh Mehrafrooz MayvanFaculty of Science
f.mehrafrooz.mayvan@liacs.leidenuniv.nl | 071 5272727
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Labor movements and party system development: Why does the Caribbean have stable two-party systems, but the Pacific does not?
How can we explain that Caribbean small states have the most stable two-party systems in the world, while Pacific small states have either very weak parties or no parties at all? Matthew Louis Bishop (University of Sheffield, UK), Jack Corbett (University of Southampton, UK) and Wouter Veenendaal (Leiden…
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Handbook of Signal Processing Systems
Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Exploration on and of Networks
This dissertation consists of two parts, with the common theme
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investigation of the photoprotection mechanism of Light Harvesting Complex II
Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.
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A brain-wide map of neural activity during complex behaviour
A key challenge in neuroscience is understanding how neurons in hundreds of interconnected brain regions integrate sensory inputs with previous expectations to initiate movements and make decisions.
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Mechano-transduction mediated by integrin-based adhesion complexes: integration of cytoskeleton and adhesion dynamics
In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.
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Bartolomeus Häussling LöwgrenFaculty of Science
b.j.p.m.haussling.lowgren@cml.leidenuniv.nl | 071 5272727
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Md Faysal TareqFaculty of Science
m.f.tareq@cml.leidenuniv.nl | 071 5272727
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Alexis de ColnetFaculty of Science
a.e.h.de.colnet@liacs.leidenuniv.nl | 071 5272727
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Constructing elliptic curves of prescribed order
Promotor: Peter Stevenhagen
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Isogeny graphs, modular polynomials, and applications
This thesis has three main parts. The first part gives an algorithm to compute Hilbert modular polynomials for ordinary abelian varieties with maximal real multiplication. Hilbert modular polynomials of a given level b give a way of finding all of the abelian varieties that are b-isogeneous to any given…
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Dusty perspectives on the cradles of planets
Astronomy began by studying the light from the stars. These stars are born in vast clouds of gas and dust.
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Hüseyin BeyköylüFaculty of Social and Behavioural Sciences
h.beykoylu@fsw.leidenuniv.nl | 071 5272727
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Why is the formation process in Belgium so complex?
The Belgian elections are over. Now it is up to the formateur to form a cabinet, but that is difficult. Fauke Deceuninck, program leader of Politics and Governance at the Center for Professional Learning, explains to Speechmakers why that is.
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modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
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Systemic Accountability of the European Border and Coast Guard
On 11 November 2021, Mariana Gkliati defended the thesis 'Systemic Accountability of the European Border and Coast Guard'. The doctoral research was supervised by Prof. P. Rodrigues and Prof. L. Besselink (UvA).
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scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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FAIRDOM – FAIR Sharing for Systems and Synthetic Biology
FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Gut Microphysiological Systems for Toxicology: Scalable Assays for Industry Implementation
PhD defence
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Combining surgery and systemic therapy in metastatic melanoma
PhD defence
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Ben WielstraFaculty of Science
b.m.wielstra@biology.leidenuniv.nl | 071 5275135
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Garnet AkeyrFaculty of Science
g.j.akeyr@math.leidenuniv.nl | 071 5274845
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Shruti JainFaculty of Science
s.jain@cml.leidenuniv.nl | 071 5272727
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…
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Willem MeilinkFaculty of Science
w.r.m.meilink@biology.leidenuniv.nl | 071 5274882
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More than a digital system: how AI is changing the role of bureaucrats in different organizational contexts
In this paper, Sarah Giest and Bram Klievink highlight the effects of AI implementation on public sector innovation. This is explored by asking how AI-driven technologies in public decision-making in different organizational contexts impacts innovation in the role definition of bureaucrats.
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Tiny clumps recycle themselves into complex structures
Manufacturers produce high-end technology mostly top-down with large machinery, but small particles are able to build structures by themselves from the bottom up. A major challenge is that these particles easily clump together. Leiden physicist Daniela Kraft has developed a method to use this phenomenon…
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
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Short Update on the Wijnhaven Complex
The building is far from finished, but the former ministry of Internal Affairs is looking more and more like the Academic building for the locations of the University of Leiden in the Hague that it has to become. This week I got a tour behind the scenes of the gigantic project, where I was able to see…
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Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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intelligence needs an overhaul because the threats are becoming more complex
Many intelligence services have an outdated view of the world while the threats they should protect us from are becoming more complex. Serviceman and researcher Bram Spoor warns that NATO and member state intelligence organisations cannot always predict the dangers.