Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.

Denying war crimes and genocide is prohibited by law in the Netherlands. Minimising international crimes can also have far-reaching consequences, warns Marloes van Noorloos, Professor of Criminal Law and Criminal Procedure, in Trouw newspaper.

On 27 september historian Adam Zamoyski held a captivating lecture on his new book Napoleon: the Man behind the Myth. During this lecture, which was an initiative by Polen in Beeld and the Central and Eastern European Studies Center, Zamoyski answered the question: ‘what were the Napoleonic Wars really…

On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…

Political scientist Corinna Jentzsch (Leiden University) explains why Mozambique is not (yet) a success story.

Drug use during pregnancy seems like a choice without any consequences. However, the Dutch Public Prosecution Service (OM) has decided to prosecute a mother for using alcohol and drugs during her pregnancy. Mariëlle Bruning, Professor of Child Law, tells current affairs programme ‘Nieuwsuur’ that she…

On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…

Paul Christiaan Flu, originally from Surinam, was a brilliant tropical doctor, who in 1938 rose to the position of Rector Magnificus of Leiden University. The war years brought his lightning career to an abrupt end: his son was murdered and he himself was imprisoned in a concentration camp. A sad family…

Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years

Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…

During the ‘Hour of Remembrance’ on 4 May, the University community remembers its students and staff who were killed in the Second World War. It also looks at freedom and oppression today. Three questions for Sara Polak, chair of the Hour of Remembrance committee.

LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…

‘That hornets’ nest in Leiden must be destroyed,’ said Dutch National Socialist Party member Robert van Genechten in November 1942. He was referring to Leiden University. Why this hatred? Emeritus Professor of University History Willem Otterspeer has written a book about Leiden University during the…

Four years of war in Ukraine have transformed the nature of warfare, with drones, digital defence systems and improvised solutions shaping the battlefield. At a recent symposium, Dutch and Ukrainian experts discussed frontline conditions. What lessons do they see for Europe?

Conference

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Rob van Wijk gave an interview on the role of zebrafish in drug discovery and development, published in FIGON’s journal Medicines as a preview of LACDR’s representation at the PhD competition during the Dutch Medicines Days (DMD). The entire interview can be read below.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…

Courts that adjudicate war crimes or other crimes against humanity are increasingly taking regional norms and cultural values into consideration. PhD candidate Seun Bakare examined whether this could also be an asset in cooperation with the International Criminal Court (ICC).

Sandy Overgaauw has been awarded a 25,000 euro grant from the LUF for her research into PTSD in Syrian refugee children in the Netherlands. The research should lead to a screening method that can be used to determine which children are at higher risk of developing posttraumatic stress disorder (PTSD…

An overview of research projects at the Predictive Pharmacology group.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

The one-day symposium ‘War in Europe: the impact of Russian aggression in Ukraine two years on’ on 23 February 2024

This thesis describes the design, characterization and application of dextran based crosslinked network.

One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Sometimes an idea seems so logical and elegant at first glance, that you later wonder why no one thought of it before. Two researchers from LACDR have teamed up to develop a completely synthetic alternative to antibodies—one that mimics their size, shape and function, but which is cheaper, more stable,…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

A new government, conflicts around the world and obviously a lot of science: these are the five stories about Leiden University that you enjoyed reading in 2024.

The gripping story of a collective passion for freedom that shook the world.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

The American president Trump is considering military intervention in Mexico to get rid of the drug cartels once and for all, but Mexico is not interested in other countries' interventions. According to Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs, Trump's much…

In her capacity as a lawyer and expert in International Humanitarian Law and Human Rights, Professor Helen Duffy is filing a lawsuit against the Dutch State. Leiden University’s weekly newspaper Mare reports that through her role, Duffy is assisting a Palestinian Dutchman whose family was killed in…