Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

Mechanisms fro drug resistance

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Formulation of biopharmaceuticals

Promotor: A.P.IJzerman Co-promotor: A. Bender

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Discovery of metastasis promoting candidate drug targets

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

During the course of drug discovery translational steps are made.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The specialisation enables you to understand the fundamentals of management and entrepreneurship alongside high quality Bio-Pharmaceutical research at a world class institute.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

PhD defence

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

PhD defence

PhD defence

The following sources were consulted for this guide:

Do you want to apply for this master’s programme at Leiden University? Find out how to apply for your programme by following the step-by step guide in the application and admission section.

Kralen spreken tot de verbeelding. Ze zijn aantrekkelijk en persoonlijk vanwege hun kleuren, materialen, patronen en associaties. Je draagt ze op je lichaam, waar je ze voelt en anderen ze zien. Kralen zijn waardevol en verplaatsbaar, tegelijkertijd reizigers en souvenirs.

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Leer meer over de Master Education and Child Studies tijdens de Online Master's Open Dagen van de Universiteit Leiden.

FAIR-ASSESS brings together researchers from five different Leiden faculties, as well as experts from outside the university. The project has been initiated by Andrei Poama and is being led by Josette Daemen.

Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…

Many lecturers aim to make their courses more diverse, but they often encounter problems in the process. How can they receive the information they need? This project ‘Wanted: roadmap’ develops a roadmap for Dutch (academic) historians to bring diversity into practice. BA1 teaching in Graeco-Roman history…

PhD defence

Lecture, Leids Actualiteitencollege

Inaugural lecture

Inaugural lecture