Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Psycho-physiological studies for health and disease.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

2026

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.

The Disticha Catonis by Catenaccio of Anagni. A text in vernacular from Latium (late 13th - early 14th century)

The oldest forms of literature and law originate from Mesopotamia (3000 BC until AD 70), as do important discoveries in science and technology. All these developments were recorded in cuneiform texts on clay tablets. There is still a lot to learn from the study of cuneiform texts, says Professor of…

PhD defence

PhD defence

Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.

The coronavirus outbreak has demonstrated the strengths and weaknesses of modern diplomacy. In this two-part series of blog posts, I will attempt to analyze how diplomats grappled with the coronavirus pandemic and how international diplomacy can best prepare to meet similar challenges in the future.…

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Meet the scientists within the LED3 community

The Psychology Research Seminars are organised by and for institute staff. They offer an opportunity to share knowledge, gain new insights, and meet colleagues from various disciplines.

Gathering and distributing patient data can make an important contribution to containing the coronavirus. But if we want to be successful, we need better data. With this objective in mind, Leiden data stewards have joined the Virus Outbreak Data Network (VODAN).

‘The idea that overweight and obesity are the fault of parents and/or the child, is rubbish.' Roxanna Camfferman, who specialises in child and adolescent studies, explains her proposition. Her PhD dissertation is on the role of upbringing in child obesity.

Global notebook (GN) is an educational and socially responsible startup, created by two LU alumni. They built an exciting program, combining Brussels and The Hague, in the form of a week long international student conference - global notebook conference (GNC). Young curious minds from all over the world…

In recent days and weeks, experts have been falling over themselves to point the finger at the main culprit in the Dutch child benefits scandal. Although this debate is fascinating, equally important are the broader lessons to be drawn from the scandal in relation to constitutional and administrative…

Prof. Ton Liefaard connected to around 150 legal professionals in India and beyond to reflect upon the COVID-response of governments from a children’s rights perspective.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

On Friday afternoon, 15 November 2024, the conference Corporate Responsibility: Current Issues in the Field of Fundamental Rights & Sustainability will take place.

Since Russia’s invasion of Ukraine in February 2022, the European Union (EU) and its Member States have adopted wide-ranging legal and political measures to support Ukraine in its struggle.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The recent rise in global migration movements and the simultaneous attempts to prevent migrations to the Global North in general and Europe in particular have produced numerous images and narratives that try to record and convey these events and their actors.

What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

How are the epidermal lipid pathways involved in health and disease.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Our research aims to develop drugs that boost the host immune response to better defend us against mycobacteria.

On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.

Key publications of the Skin Barrier and Vaccination group.

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.