What is the role of stress and stress-related hormones in emotion regulation?

Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Vicencio Oostra, who defended his PhD-thesis at the IBL successfully in June 2013, published new insights into the hormonal regulation of butterfly responses to fluctuating environments.

Psychologist Ellen de Bruijn is investigating what hormonal fluctuations do to women's behaviour and well-being. The National science funding body NWO honoured her research with a Vici grant; earlier this year she received an ERC Consolidator Grant. Read the interview with De Bruijn about her resear…

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Psychologist Ellen de Bruijn studies the effects of hormonal fluctuations on behaviour and on the brain over a woman's life course. With an ERC Consolidator grant, she and 3 PhDs and a postdoc will further her EEG research on the different stages at which girls and women experience strong hormonal f…

Promotor: P.M. Brakefield

An important hormone excreting gland in the human body is the pituitary

Leiden University has appointed John van Noort as Professor in Biophysics. He studies the way in which our DNA is folded and read out.

John van Noort

PhD defence

Stress and overwork are massive problems today, but relatively little is known about stress factors in the past. With a look at the deep history of stress, Sarah Schrader hopes to get a better understanding of the human stress experience. Her project application received an NWO XS grant.

Is it possible to pharmacologically condition oxytocin responses in healthy individuals and identify the neural circuitry underlying such conditioning?

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

YAL now has its own lecture series! In collaboration with Studium Generale, we organise ‘Young Academy Leiden lectures'.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Supervisor: Indira Nederpelt

It often takes longer for women with heart problems to get the right diagnosis. In her Annie Romein-Verschoor Lecture, Professor Hester den Ruijter will talk about how hormones influence the heart and the importance of medical research that focuses specifically on women.

How do common marmosets combine their calls into sequences and how are their vocalisations influenced by reproductive state?

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

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Visualization of biomolecules in living cells by tagging with gold nanoparticles.

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

How is structural and functional brain development related to behavioral change in cognitive-control, impulse regulation, and socio-emotional functioning?

Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

How do individuals make decisions? What determines the quality of group decisions? When and why do people cooperate with others? How does intergroup competition evolve?