The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

The research group Corporate Governance and Strategy investigates how, with whom and for whom a firm/corporation creates/captures value, in order to inform practice and rule makers about governance issues. By focusing on the dual character of the firm as an entity by itself but also consisting of stakeholders,…

In our new strategic plan (Innovating and Connecting – 2022-2027) we focus on stronger connections: between disciplines, with society and within our university community.

Both the international perspective and the Dutch language and culture are deeply embedded in Leiden University’s identity.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Blended and hybrid teaching are presented as crucial in promoting teaching innovation, as well as more flexible study approaches allowing students to develop their own tailor-made study programmes. While the strategy document focuses on the positive aspects of digital teaching tools, no systematic study…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

What does our faculty stand for and what will we do in the next five years? We are proud to present our new strategic plan that we made together. On this website you will find more information about what our Faculty stands for and what our course is for the coming years

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

The focus of health care is rapidly changing. The need for maximum gains with minimal input requires tailored health care strategies and an ever more explicit evaluation of health benefits for the patient.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

To what extent and in what manner can experimental video be used to reclaim the capacity for telling one’s own story, on one's own terms, speaking in tongues outside the linguistic framework of immune system discourse?

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This research hopes to contribute to social awareness of the consequences of colonialism for Indigenous Peoples, to the deconstruction of still existing colonial and discriminatory notions and to a better appreciation of Indigenous art and thought.

Few events have influenced our global order as intensely as the events of September 11, 2001.

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Arco Timmermans’ handbook unites experts to examine public affairs, its challenges, and its alignment with democracy and open society.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Lecture

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

A comparative analysis of legitimation strategies in tree hybrid regimes: Russia, Venezuela, and Seychelles.

In Europe, archaeological traces of fire become more frequent between 300,000 and 400,000 years ago; but could the earliest occupants have survived without fire for at least half a million years before this? How could the early occupants of Europe have kept warm and processed meat without fire?

Volume II of The Cambridge History of Strategy focuses on the practice of strategy from 1800 to the present day.

Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.

Volume I of The Cambridge History of Strategy offers a history of the practice of strategy from the beginning of recorded history, to the late eighteenth century, from all parts of the world.

Our previous meta-analysis (Swart et al., 2019) had shown that feedback targeting text comprehension given when students perform a reading task positively influences learning from text. So far, differences in the effects of feedback were explained by design features, such as the timing and richness…

The main question I want to answer is about the mutual influence between the cultural and settlements changes that occurred between the Bronze and the Early Iron Age in Margiana and the management of water resources.

This article presents a five-step framework for building behavioural cybersecurity strategy to reduce human-related risks affecting organisational security

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

This study presents the findings of a laboratory-based experiment testing hypothesised processes implicated in the prevention of violent radicalisation through counter-narratives. The central aims of the study were to contribute to counter-narrative theory, whilst highlighting the value of experimental…

This project aims to provide evidence-based knowledge on the conditions for successful anti-corruption activism in Ukraine.

Article by Annemarie Samuels in History and Anthropology

From ca. 1540 to 1600, thousands fled the war-stricken Southern Low Countries to the British Isles, Germany, and the Northern Low Countries. Research on this displacement crisis, central to the formation of the Netherlands and Belgium, reflects 21st-century debates on migration and language: language…

Agriculture is among the most vulnerable sectors to climate change and poorer countries face the most severe difficulties. Coffee farmers in Central America, for instance, are facing multiple and mutually reinforcing crises, including price shocks, outbreaks of pests and diseases, migration, and farm…

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

How can we make agricultural production systems more sustainable as the worldwide demand for healthy, safe food continues to grow? How can we develop healthy new food crops that have higher yields while requiring fewer harmful chemicals?

The project will support Responsible, Research and Innovation (RRI) policy experiments in the healthcare sector in three European territories: in Murcia (ES), Örebro (SE) and the Republic of Cyprus (CY). CHERRIES will engage the territorial stakeholder ecosystems in participatory agenda setting, need…

Proceedings of the 25th International Congress of Roman Frontier Studies 2

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.