Hoping to learn something about the human brain, Leiden researchers are creating a setup to shoot single photons, particles of light, into someone’s eye. ‘The eye is a passageway to the brain.’

Maaike Kempes believes more attention should be paid to non-congenital brain injuries in suspects. This may partly explain their criminal behaviour.

To understand how the brain works, it is essential to map it out in detail. This appears to be possible with a microscopy technique in which Leiden physicists excel. This breakthrough could significantly advance the human quest to understand brain functions.

The brain structure of young people with conduct disorder differs significantly from that of their typically developing peers. This is the conclusion of an international study that analysed more than two thousand MRI scans, recently published in The Lancet Psychiatry. Dr Moji Aghajani, one of the principal…

It may seem as though adolescents do as they please, but they are more sensitive to their parents’ opinions than they would appear. The adolescent brain reacts strongly to parental criticism or praise. These are the results of a study by an interdisciplinary research group of psychologists and neuroscientists…

What happens in the brains of people with psychiatric illnesses? With a €23.23 million gravity grant, scientists from different fields will search for biological causes over the next decade. ‘By joining forces, we hope to improve diagnosis and treatment for patients with these diseases.’

A unique multicenter study, including about 3,500 youth between 10 and 25 years old from across the globe, shows that artificial intelligence - specifically machine learning - is able to identify individuals with anxiety disorders based on their unique brain structure.

Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.

Why do some people with adverse childhood experiences develop mental health conditions whereas others do not? A Leiden research project is looking for volunteers aged between 18 and 24 to help us understand more about human resilience.

Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.

Parents appear to be extremely sensitive to feedback they receive about their child. Just how sensitive depends on the (‘rose-tinted’) glasses through which they look at their child. All this can be seen in the brain. Neuroscientist Lisanne van Houtum and her Leiden colleagues published on this issue…

Could we stop cancer cells by cutting off their energy supply? That’s what Dione Blok, a bachelor’s student in Bio-Pharmaceutical Sciences, aimed to find out during her thesis research. She investigated a compound that affects the tumour cells’ energy metabolism. ‘Hopefully, these insights will provide…

'With this artwork, I want to give the audience a glance into my overstimulated brain and that of other people with autism', says Jasmijn den Hoed. The Faculty of Social and Behavioural Sciences is exhibiting her artwork 'Overstimulated' in the restaurant near the blue wall during Autism Week 25 March…

During adolescence, some young people have stable best-friend relationships, while others change best friends frequently. Developmental psychologist Lisa Schreuders has studied the brains of young adolescents: ‘It seems that friendships in your early years can have consequences for your friendships…

How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.

Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience.

Eastern and Southern European countries struggle with ‘brain drain’ as skilled workers move to other EU Member States. Could restricting free movement be a legitimate and lawful way to address this trend? Researcher Martijn van den Brink will investigate the issue.

Lecture, Tuesday Talk

The more data from cancer research we pool, the better we can search for new treatments. But how can we keep patient data safe when sharing it? Leiden researchers will tackle this challenge in a major European project.

This study is important because it seeks to uncover whether clinicians' communication influences neurobiological and physiological outcomes for patients.

One used 3D cell models to study colorectal cancer, while the other used machine learning for more efficient blood donation. For these achievements, Marieke Vinkenoog and Simon Christian Hansmann were awarded the Krijn Rietveld Memorial Innovation Award on Tuesday 2 September.

Half of all people with cancer in the Netherlands are aged 70 or older, and as the population continues to age, this number will only rise. Yet vulnerable older people with cancer are often overlooked, says PhD candidate Joosje Baltussen.

On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

BRAIN Biotech and the Leiden University will jointly develop an Aspergillus based production strain with high yield and thus contribute to a bio-based circular economy. The cooperation is based on BRAIN´s molecular tool BEC.

Deep-brain stimulation (DBS) is the most promising surgical treatment for movement and neuropsychiatric disorders, but is accompanied by unwanted side effects. Birte Forstmann, professor by special appointment, has been awarded a ERC Proof of Concept Grant to create an atlas of the human deep brain…

Sebastian Pomplun from the Leiden Academic Centre for Drug Research has recently received an ERC Proof of Concept grant for his ambitious MYSTIC project. This initiative is set to transform cancer treatment by advancing the development of HeloMYC, a pioneering therapeutic candidate designed to target…

There is a reasonable chance that you came to this reading list through a social medium. Now it's our job to keep your attention. We are going to do our best. There are so many distractions; from notifications on your phone, to another screen near you, that may also be screaming for attention. Every…

During ExpeditionNEXT in Middelburg, NeurolabNL youth, together with researchers from Leiden University and Erasmus University, handed over a unique research agenda to NWO Chairman Marcel Levi. In it, young people share what they would most like to learn about themselves and the brain.

When we hear the word ‘bird house’, do we process it as a whole or does our brain see it as ‘bird’ and ‘house’? PhD student Jiaqi Wang explored this for speakers of Mandarin Chinese.

Nausea, neurologic pain and hair loss: some of the severe side effects of chemotherapy. Not necessary, biochemist Liyan Zhang showed. Together with Leiden biologists and others, she achieved great results with a drug that is only active in combination with light. Zhang will defend her PhD on 4 July.

Since its discovery thirty years ago, it remained a mystery: how does the body’s own marijuana move between nerve cells in the brain? Mario van der Stelt and his research group have now uncovered the answer. This insight could aid the development of new treatments for pain and neurological disorders…

How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…

‘We didn’t find any mechanisms in the brain for transmitting child abuse from generation to generation. What we did find is that experiences of neglect and abuse affect the brain differently,’ concludes Lisa van den Berg (Clinical Psychology). PhD defence 30 June.

The risk of a brain tumour recurring can be predicted more accurately by counting the number of immune cells in the tumour under a microscope. These are the findings from research conducted by LUMC, Erasmus MC and Heidelberg University.

Accelerating the development of new cancer medicines by joining forces—that’s the mission of Oncode Accelerator, a Dutch consortium that recently welcomed three Leiden-based PhD candidates. Under the guidance of Gerard van Westen, Marc Boef, Remco van den Broek, and Lucina-May Nollen are exploring how…

Feeling good doesn’t just lift our mood—it also helps us stay flexible and resilient. A new study by an international team of neuroscientists shows that natural brain opioids released after rewards play a key role in broadening attention, offering fresh insights into stress, cognition, and well-bein…

PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.

Part of our social contact is currently online, with no physical proximity. Does digitalisation mean that we are losing an effective way of making contact with one another? This is what Reinoud Kaldewaij will be studying with a Veni subsidy from the Dutch Research Council (NWO). 'An issue that will…

Hunter-gatherers acquire their food through complex gender-specific foraging techniques for a relatively stable and diverse supply of energy. New research indicates that this specialisation by boys and girls starts at a very young age. Most likely, this enabled the human species to evolve much larger…

If doctors could better estimate a patient's chances of survival, this would help in choosing a specific treatment. It would be particularly beneficial for the rare and malignant Ewing sarcoma, which mainly affects children and adolescents. Mathematics professor Marta Fiocco has been awarded a substantial…