930 search results for “bioactive molecules” in the Public website
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From discovery to business: 'In the lab, we often don't realise that we are working to help an immense number of patients'
'It gave our team a big boost to hear that our work was valuable,' says medical chemist Elmer Maurits about the moment they won the Venture Challenge. With their company Iprotics, they want to develop a drug that can better treat patients with autoimmune diseases and blood cancers. 25,000 euros of prize…
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New measuring method reveals: more plastic ón than ín your salad
It's now possible to measure how many plastic particles there are in our food. Chinese scientists and Leiden professor Willie Peijnenburg applied their new method to lettuce and wheat. Their results were published January 20 in Nature Nanotechnology.
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In Memoriam - Joan van der Waals
On 21 June, our beloved colleague Joan van der Waals passed away after a long and rewarding life.
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Fat-free mayonnaise thanks to manipulation of surface tension
Aqueous solutions of proteins and carbohydrates separate into two parts with an extremely ‘soft’ boundary surface. The surface tension between these two parts can be manipulated, for example by adjusting the pH balance. This can be used to develop emulsions of a water-based solution in another aqueous…
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Halting protein degradation may contribute to new cancer treatment
Chemist Gerjan de Bruin has designed a method of slowing down the degradation process of proteins in cells. This may contribute to new cancer medicines with fewer side-effects. PhD defence on 1 June.
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Non-invasive DNA-labeling tool opens doors for new research
Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published their findings in the journal Nucleic Acids Research.
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ERC Synergy Grant to unlock sugar codes for health and a sustainable society
Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…
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Leiden celebrates tenth anniversary of ERC
The European Research Council, better known as the ERC, turns ten this year, and researchers from Leiden celebrated this on 23 June. The ERC is an important provider of research funding, also to Leiden University. Over the past ten years researchers from the University have been awarded over 70 ERC…
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Rethinking drug discovery: Vidi grant for Laura Heitman
Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.
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New funding for advanced microscopy using gold nanorods
A consortium of researchers from the Leiden Institute of Physics (LION), the Institute of Biology Leiden (IBL), and the Leiden Institute of Chemistry (LIC) received a FOM program grant to develop a novel way of studying individual proteins inside a cell using gold nanorods.
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Leiden breakthrough in research on nanotherapy
Nanoparticles that transport medicines to a specific part of the human body are usually broken down in the liver prematurely. Jeroen Bussmann from Leiden University has discovered a new method to prevent this from happening. Publication in ACS Nano.
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First Leiden Science Family Day: glitter gel, virtual reality and ice-cold clouds
The first Leiden Science Family Day on Saturday 6 October was a great success. During the ‘Weekend of Science’ more than 700 visitors, including 350 children, visited the Faculty of Science. With a program full of experiments, lectures, guided tours and demonstrations, visitors were given a glimpse…
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ERC Starting Grant for Roxanne Kieltyka: stem cells in gels
Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.
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Smart chemistry rids anti-cancer drugs of serious side effects
Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…
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Faculty of Science opens academic year with responsibility call and nanoparticles
On Tuesday 4 September, in a full lecture hall C1, Dean Geert de Snoo opened the Academic Year for the Faculty of Science. A year in which the ethics and responsibility of scientists will be invoked.
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These are the seven Veni winners of the Faculty of Science
The Faculty of Science has received no less than seven Veni grants this year. Camila Correa, Max van Duijn, Stéphanie van der Pas, Sergii Pud, Mónica Varela Álvarez, Joseph Callingham, and Melissa McClure will receive a maximum of 250,000 euros to further develop their own research ideas over a three-year…
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Ewine van Dishoeck wins Kavli prize for astrophysics
How are stars and planets formed? Is life outside Earth possible? These questions are being researched by Professor of Molecular Astrophysics Ewine van Dishoeck at Leiden University. Her pioneering work has earned her the Kavli prize in the category of astrophysics. The prize consists of 1,000,000 dollars…
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Spinoza Prizes for physicist Michel Orrit and psychologist Eveline Crone
Of this year’s four NWO Spinoza Prizes, two have been awarded to Leiden researchers. On 12 September, Eveline Crone and Michel Orrit received their prizes, the highest scientific award in the Netherlands. The Spinoza Prize carries an award of 2.5 million euros.
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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A look behind the scenes at the Leiden Science Family Day
More than 700 visitors got to know the Science Faculty during the Leiden Science Family Day. People of all ages could enjoy fascinating experiments, tours, interesting lectures, spectacular nitrogen shows and various workshops. It was an informative day with many (future) scientists, amazement and,…
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'If you think astronomy is a man's world, then it's your job to make a change'
During her master's thesis, Nashanty Brunken (24) worked in a team with five other women. With this female team, they discovered the largest molecule so far identified in a disc. 'I have learned so much and because we are all women, it is incredibly empowering. It's very cool to see how far we've come…
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European project ImageInLife has started
The Horizon 2020 project ImageInLife has started on 1 January, followed by a kick-off meeting at the coordinating University of Montpellier at the end this month. This Marie Skłodowska-Curie training network brings together European groups that work on the imaging of vertebrates and offers fourteen…
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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Training
As a PhD candidate, you are expected to follow certain courses and training programmes in the context of your training as a researcher. The courses and training programmes will help you conduct your research, write your dissertation, develop your career, and gain self-insight. The LACDR PhD training…
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In Memoriam: Robert Louw 1936-2023
On 18 February 2023, our esteemed former colleague Robert Louw passed away. Rob was 86 years old.
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Best presentation award for Andreea Nadaban at European congress
A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.
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BBC Science Focus names Ewine van Dishoeck as one of the six women who are changing chemistry
On the occasion of the Women & Girls in Science Day, BBC Science Focus Magazine highlighted 6 prominent female chemists. Among them is Leiden professor Ewine van Dishoeck: 'Astrochemist investigating the building blocks of life'.
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Inaugural Lecture Professor Herman van Vlijmen
Prof.Dr. Herman van Vlijmen was appointed as Professor of Computational Drug Discovery at the Division of Medicinal Chemistry in Leiden on April 15th, 2008. He will give his Inaugural Lecture on May 18th, 2009.
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SBB team wins Philips Innovation Award
On Monday May 8th, two Leiden Startups took part in the finals of the Philips Innovation Awards. One Leiden venture, Levels Diagnostics, was selected as the winner of the €10.000,- price in the category of ‘Rough Diamonds’.
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Jeroen Codee wins the Carbohydrate Research Award 2017
For his significant original contributions in the field of carbohydrate research, chemist Jeroen Codee will be awarded the biennial Carbohydrate Research Award for Creativity in Carbohydrate Chemistry.
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Various media on drug research Mario van der Stelt
Media in the Netherlands and abroad reported extensively about the drug research led by Leiden chemist Mario van der Stelt. In this research, Van der Stelt shows which unwanted side-effects a French drug candidate has.
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Freek Janssen wins award for best European Young Medicinal Chemist
Freek Janssen, a PhD-student in the department of Molecular Physiology, has received an award for the best oral presentation during the Young Medicinal Chemist Symposium organised by the European Federation of Medicinal Chemistry (EFMC-YMCS’16). Freek Janssen presented his work on “Development of Highly…
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Ewine van Dishoeck receives prestigious Kavli Prize
Ewine van Dishoeck, Professor of Molecular Astrophysics, was presented with the Kavli Prize by King Harald V of Norway during a ceremony on 4 September in Oslo. The prize consists of a gold medal and one million dollars.
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LION Summer School: Modern Physics at all Scales
From 16 to 26 July, the Leiden Institute of Physics organizes its annual summer school, titled ‘Modern Physics at all Scales’.
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Leiden astronomers in astronomy podcast
Five Leiden astronomers tell about science in the podcast Astronomy et al. This podcast was set up by Ricardo Garcia Soto in September 2016 and is focused on anyone who is interested in science.
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Leiden involved in three out of five Physics Vrije Programma grants
NWO has assigned Physics Vrije Programma grants to five collaborations of physicists. Leiden University is involved in three of them.
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Royal honour for emeritus professor Ad IJzerman
Ad IJzerman, Emeritus Professor of Pharmacochemistry, was made a Knight of the Order of the Lion of the Netherlands on 26 April. He was presented with the royal honour by Mayor Elbert Roest in the town hall in Bloemendaal.
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Physics Summer School kicks off
From July 22nd to August 1st, the Leiden Institute of Physics organizes its annual summer school, titled ‘Modern Physics at all Scales’.
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Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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Metals for Catalysis and Sustainability
Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…
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Exploring the Universe
Astronomers want to understand the Universe, from the Big Bang to the present day, and what the future will hold. In Leiden they focus on two key questions: ‘How did stars and planets originate’ and ‘How were galaxies and black holes formed in the young Universe?’ A new generation of telescopes – just…
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LED3 PhD-Postdoc Symposium 2024
Conference