480 search results for “bipolar disorders” in the Public website
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Does the human brain process angry voices automatically?
Using brain imaging to discover the area in the brain that recognizes emotion.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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Morin Lab - Synthetic Soft Condensed Matter
We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.
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Challenged by cognition
Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Leiden Institute for Brain and Cognition
The Leiden Institute for Brain and Cognition (LIBC) is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition.
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Victims at the Crossroads
Dr. Pauline Aarten tries to find answers of the impact a road traffic accident has on the victims and surviving relatives and how we can improve their position.
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Neurofibromatosis Type I
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Impact
With our research and teaching, we help make the world a better place. We join in the academic and public debate, and seek answers to economic and social issues – not just at the local and regional level but at the global one too.
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Chronobiology of depression
What are the circadian disturbances underlying depression vulnerability? How are they related to mood, cognition and sleep ?
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PhD position
Develop EPR instrumentation and methodology to investigate intrinsically disordered proteins (IDPs).
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Rebels and Legitimacy: Processes and Practices
Legitimacy is generally a term that is associated with the state. The term surfaces when there are problems with state legitimacy—when it is lacking or absent. This present volume attempts to think through the relevance of the concept of legitimacy for other political actors than the state.
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Education
The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.
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Sybil-AA: Systems Biology of Alcohol Addiction
The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…
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Social Anxiety and Specific Phobia in youth
Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!
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Topic: E-health
The research connected to this topic is related to E-health.
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Justice in the Himalayas: Local Expectations and Legal Interventions
Consensus and harmony or balance and reciprocity?
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Genetic, biochemical and neural correlates of vulnerability to depression.
How do genetic and environmental factors make us vulnerable to depression?
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Eye gaze behavior in socially anxious individuals
Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Cognitive Psychology
Cognitive psychology is the study of cognitive functions such as attention, memory, consciousness, emotion, language and action control. The goal is to understand the complex relationships between brain, mind and behavior.
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Lab facilities Clinical Neurodevelopmental Studies
Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.
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About the programme
The programme of the master specialisation Learning Problems and Impairments studies common learning problems such as dyslexia, hyperlexia and dyscalculia, as well as learning disabilities caused by AHDH, ADD or speech and language disorders. Much attention is also devoted to the relation between brain…
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Advancing the European Multilingual Experience
The project Advancing The European Multilingual Experience (AThEME) studied multilingualism in Europe by incorporating and combining linguistic, cognitive and sociological perspectives.
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Master Projects
Master projects are available in
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Pushing the envelope of nuclear magnetic resonance spectroscopy for paramagnetic systems
A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…
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Topic: Spatial thinking
Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…
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Book Learn to Dare/DDD
In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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The empathic mind in children and adolescents with Specific Language Impairments (SLI)
The ‘empathic mind’ in children with Specific Language Impairments (SLI); what can children with SLI understand of other people’s minds and emotions?
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Blended Care for Adolescents with Social Anxiety
Is blended care a feasible and effective treatment method for social anxiety in adolescence?
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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Utopia: Universal Three-dimensiOnal Passport for process Individualization in Agriculture
Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…
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Building blocks of success
A research into for whom, when and why the Cool Little Kids intervention works.
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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'Policing European Metropolises project'
The first results of the “Policing European Metropolises project” (PEMP) that associate Professor Elke Devroe and Professor P. Ponsaers launched in April 2013 are now published. Having been the referent for The Netherlands and Belgium in the Urbis project (Leonardo programme), the project focuses on…