The results of the investigations by citizens are used in an innovative research project that investigates the potential of machine learning and automated detection in archaeology.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

On 8 January 2020, Jelmer Brouwer defended his thesis 'Detection, detention, deportation'. The doctoral research was supervised by Prof. J.P. van der Leun and Prof. M.A.H. van der Woude.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Our group explores the larger domain of quantum measurement. In particular we investigate two themes that are closely connected: The detection of specially prepared quantum states of light and understanding and characterizing quantum photon detectors.

Promotor: Prof. dr. I. Snellen, Co-Promotor: Dr. M. Kenworthy

Promotor: E. Bouwman Co-Promotor: S. Bonnet

On the 10th of November, Martin Kroon successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Martin on this achievement!

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

So far it has been impossible to compare large sets of syntactic constructions in large sets of languages systematically and automatically. The online availability of parallel text corpora and software tools to align, enrich, search and analyse them has the potential to make automatic massive systematic…

Miles Kellerman, Assistant Professor at Leiden University, argues in a new article that governments should consider empowering financial crime bounty hunters by creating Licensed Detection Agents to address structural failures in current systems for detecting financial crime.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Deepfakes are videos that have been manipulated to replace one person’s likeness with that of another. They can be difficult to distinguish from authentic videos. In our study, we found that people who score high on conspiracy thinking and people who use social media more are better at distinguishing…

Generally the data from remote sensing surveys - the scanning of the earth by satellite or aircraft in order to obtain information about it - is screened manually in archaeology. However, constant monitoring of the earth's surface causes a huge influx of data of high complexity and high quality. To…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Homicide engenders broad moral concerns in society, and its aftermath can be understood as a barometer for criminal justice policy. Of all homicides committed, however, only some lead to arrest, to prosecution and ultimately to conviction in court.

PhD defence

PhD defence

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Ariane Briegel wants to use bacteria to detect cancer at an early stage. Together with postdoc Alise Muok, she is developing a method to quickly and cheaply test the urine of patients for the presence of suspicious molecules. They receive a grant of approximately 150,000 euros from the Dutch Cancer…

The manual analysis of remotely-sensed data is a widespread practice in local and regional scale archaeological research, as well as heritage management.

Leiden and Jülich researchers discovered an elegant and simple approach to improve the sensitivity of graphene biosensors. These so-called ‘next generation graphene electronic biochemical sensor devices’ are able to detect very low amounts of HIV DNA thanks to their very low electronic noise.

A team of scientists, including Leiden Astronomer Alice Booth, has discovered silicon monosulfide molecules in the dust disk around a young star. Such molecules indicate planet formation. The team made the discovery using the ALMA telescopes. This method provides an alternative when direct observation…

For his PhD project, computer scientist Manolis Fragkiadakis is developing a tool that can compare videos of sign language corpora. This would make it possible to detect differences between sign languages and prevent translation errors. Ultimately, the tool could be used to compare sign languages from…

It's pretty hard to spot a single 5 nanometer particle. Leiden physicists pulled it off by turning a 120 nm gold rod into a detector.

With the emergence of social media platforms such as Twitter, Facebook and Instagram, it’s easier than ever to share information. Including disinformation. During his PhD computer scientist Xueqin Chen developed a new way to recognise fake news and predict how messages spread within online social networks…

NWO honoured Leiden psychologist Jeffrey Durieux with a Research Talent Grant for early dementia detection by identifying differences in resting-state networks.

Over the past decades within the European Union (EU), economic proliferation and globalisation have resulted in an increase in transboundary waste transportation. Although waste trading can often have positive economic and environmental impacts by repurposing natural resources within industrial sectors,…

The James Webb Space Telescope has found evidence of carbon dioxide (CO₂) in the atmosphere of a giant planet 700 light years away. This result provides insight into the composition and formation of this gas giant and shows what James Webb is capable of. The research by the international group of astronomers,…

Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

As a professor, Natasha Appelman-Dijkstra understands better than anyone how important it is to recognise bone and mineral conditions at an early stage. She emphasises the importance of flexibility and collaboration for better care, groundbreaking research and strong education.

Optical detection of a single electron using a single molecule has never been done. Leiden physicist Michel Orrit and his team have now identified a molecule that is sensitive enough to detect an electron at a distance of hundreds of nanometers. The results are published as a cover article in ChemPh…

Scientists have detected a neutrino with the highest energy ever measured. Leiden physicists Maarten de Jong and Dorothea Samtleben were involved in this project, which was widely covered in newspapers and online media last week.

An international team of astronomers, led by Will Rocha of Leiden Observatory, using the NASA/ESA/CSA James Webb Space Telescope have discovered that the key ingredients for making potentially habitable worlds are present in early-stage protostars, where planets have not yet formed.

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

Leiden physicists have managed to detect a single molecule called dibenzoterrylene in a new crystal, and found that it is a candidate component for a quantum network. Future quantum computers will need such a network to work together while maintaining their advantages. Publication in ChemPhysChem jo…

Astronomers from Leiden Observatory have developed a new method to find distant quasars and better distinguish them from other objects that look like them, using machine learning techniques. The research result has been accepted for publication in the journal Astronomy & Astrophysics. It is the last…

In the Netherlands, 1.55 million people suffer from cardiovascular diseases. Yet, acute cardiovascular events, such as a heart attack or stroke, often occur unexpectedly. That is because many people do not know they are at risk for such an event. Immunological researcher Amanda Foks and her colleagues…

By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.