Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Discovery of metastasis promoting candidate drug targets

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

What happens if a Member State decides to withdraw from the European Union? The “Brexit Charts” aim to provide information on the withdrawal procedure under Art. 50 TEU, on the legal consequences of leaving the EU and on the future relationship of the withdrawing state with the European Union.

Are you a British citizen currently studying or working at Leiden University? Or are you a Leiden University student (thinking of) studying abroad in the UK? Find out about the effects of Brexit.

Cell adhesion signaling

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Joris Larik, Assistant Professor at Leiden University, wrote about the topics of the Brexit, the EU-UK Withdrawal Agreement, and Global Treaty (Re-)Negotiations.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Promotores: J. Jonkers, K.E. de Visser

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

Ending the United Kingdom’s (UK) forty-seven year European Union (EU) membership has fundamentally transformed its relationship with the EU. After years of tumultuous negotiations, international law now once again governs the UK’s relationship with the EU. This has resulted in a sophisticated body of…

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

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Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.

A team led by Erik Danen from the Leiden Academic Centre for Drug Research has received a 3 million euros NWO Science Groot grant to unravel the first steps of metastasis. Danen will work together with biologists and theoretical and experimental physicists from Dutch Universities. ‘Understanding these…

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Mechanisms fro drug resistance

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

An essential protein that regulates our heart beat turns out to be important for cancer cells as well. The discovery might open novel treatment strategies for fighting metastasis. Publication in Science Signaling on April 4th.

The Maastricht Journal of European and Comparative Law has published an article by Christa Tobler, entitled ‚One of Many Challenges After ‚Brexit’. The Institutional Framework of an Alternative Agreement – Lessons from Switzerland and Elsewhere?’ (Maastricht Journal of European and Comparative Law 23…

On 5 December, Armin Cuyvers gave a lecture on the legal complications surrounding Brexit for Clingendael, the Netherlands Institute for International Relations.

The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Rector Magnificus Carel Stolker will retire on 8 February. If there’s one theme running through his career, it’s the links between the University and society. In this series of pre-retirement discussions, Stolker will talk one last time to people from within and without the University. This time he…

To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…