1,065 search results for “immunity infection and tolerance” in the Public website
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Novel mediators of anti-tumor immunity
PhD defence
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Rethinking Javanese Religion: The Prospect of New Descriptions of Javanese Traditions
This study describes religion in Java.
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Werken aan een effectiever malariavaccin
In het Leids Universitair Medisch Centrum wordt gewerkt aan de ontwikkeling van een nieuw malariavaccin dat effectiever is dan de huidige vaccins.
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Single-cell immune profiling of atherosclerosis
PhD defence
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An engineering approach to decode immune responses
PhD defence
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Identification of regulators of cancer - immune interactions
PhD defence
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Dissecting the immune microenvironment of breast cancer
PhD defence
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Therapeutic intervention to enhance atherosclerotic plaque stability-projects
For more information regarding ongoing research projects, please contact Dr. Ilze Bot.
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Four Leiden consortia awarded large NWO grants
No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.
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Improving therapeutic vaccines
Chemist Sander van Kasteren aims to accurately map how our immune system responds to vaccines, particularly those aimed at curing diseases like cancer and chronic viral infections. The goal is to use this knowledge to improve vaccine design. An ERC Consolidation Grant will provide him with the funding…
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Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
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Immune Thrombocytopenia: Exploring antibodies, scintigraphy and immune modulation. Moving towards a new era for patients with ITP
PhD defence
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Student projects
Are you looking for a research project?
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Antiviral Pharmacology
The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.
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Individualized prognosis in childhood immune thrombocytopenia
PhD defence
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Frank Schaftenaar
Science
f.h.schaftenaar@lacdr.leidenuniv.nl | +31 71 527 5134
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Conflicts between migrants and locals in Leiden and Rotterdam, 1680-1800
Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Jip Stam
Faculteit Rechtsgeleerdheid
j.stam@law.leidenuniv.nl | +31 71 527 6360
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Lison Laroche
Science
l.l.s.laroche@cml.leidenuniv.nl | +31 71 527 2727
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Quest for new antibiotics
Gubbens
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Projects
An overview of Quantitative Pharmacology projects
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Prosthetic Joint Infection, new diagnostic and treatment strategies
PhD defence
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Strategies in the Battle Against Neonatal Nosocomial Infections
PhD defence
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bridges: a multidisciplinary approach to controlled human hookworm infection
PhD defence
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Improving the treatment of pathogenic fungi. ‘The process is working, but not that well…’
Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…
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BEAT-COVID team discovers sugar-coated antibodies that predict disease progression
At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
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Annemarie Meijer appointed full Professor of Immunobiology
Annemarie Meijer is appointed full Professor of Immunobiology. Meijer’s research focuses on immunobiology and infectious disease. She uses the zebrafish as a model for understanding mechanisms of host immune defense against intracellular bacterial pathogens.
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In memoriam Prof. dr. Glen Newey (1961–2017)
Glen Newey, Professor of Political Philosophy and Ethics at the Institute of Philosophy, suddenly passed away on 30 September 2017. He was a remarkable personality and a unique scholar, who chaired the practical philosophy cluster at Leiden University with great enthusiasm.
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International organisations and the rule of law
International organisations that represent collaborations between States are becoming increasingly more powerful, and they have an increasing impact on our daily lives. For example, the European Court of Human Rights in Strasburg established that minors have a right to legal aid immediately following…
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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Characterization of innate immune cells in the glioma microenvironment
PhD defence