1,837 search results for “t cells” in the Public website
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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delivery of viral epitopes to redirect virus-specific CD8+ T cells to cancer cells
PhD defence
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poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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Wim 't Gilde
ICT Shared Service Centre
w.j.m.t.gilde@issc.leidenuniv.nl | +31 71 527 1865
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Sophie 't Hart
Expertisecentrum SOZ
s.a.t.hart@sea.leidenuniv.nl | +31 71 527 2727
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Joest 't Hart
Faculteit Rechtsgeleerdheid
a.c.t.hart@law.leidenuniv.nl | +31 71 527 2727
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Leendert 't Hart
Faculteit Geneeskunde
l.m.t_hart@lumc.nl | +31 71 526 9111
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Petra 't Hart
Faculty of Humanities
p.c.t.hart@hum.leidenuniv.nl | +31 71 527 2890
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Jeroen 't Hart
Expertisecentrum SOZ
j.t.hart@sea.leidenuniv.nl | +31 71 527 7259
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Marjorie in 't Veld
Universitaire Bibliotheken Leiden
m.h.int.veld@library.leidenuniv.nl | +31 71 527 2800
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Mark van 't Wout
ICT Shared Service Centre
m.j.van.t.wout@issc.leidenuniv.nl | +31 71 527 1318
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Marco van 't Hart
Universitair Facilitair Bedrijf
m.j.van.t.hart@ufb.leidenuniv.nl | +31 71 527 5337
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Kayle van 't Klooster
Faculty Governance and Global Affairs
k.c.van.t.klooster@fgga.leidenuniv.nl | +31 70 800 9506
- Eva van 't Loo
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Miranda van 't Wout
Faculty of Humanities
m.a.e.van.t.wout@hum.leidenuniv.nl | +31 71 527 5550
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Aurelie van 't Slot
Faculty of Humanities
a.van.t.slot@hum.leidenuniv.nl | +31 71 527 2727
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Arie in 't Veld
Faculteit der Sociale Wetenschappen
a.a.in.t.veld@fsw.leidenuniv.nl | 071 5273931
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Coen van 't Veer
Faculty of Humanities
c.b.van.t.veer@hum.leidenuniv.nl | +31 71 527 2727
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Arno van 't Hoog
Faculty of Humanities
a.van.t.hoog@hum.leidenuniv.nl | +31 71 527 2727
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Sebastiaan van 't Erve
Faculty Governance and Global Affairs
s.w.van.t.erve@fgga.leidenuniv.nl | 070 8008206
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Esmaralda van 't net
Faculteit der Sociale Wetenschappen
e.van.t.net@fsw.leidenuniv.nl | 071 5272727
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Sophie van 't Klooster
Faculteit Rechtsgeleerdheid
s.a.a.van.t.klooster@law.leidenuniv.nl | 071 5272727
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Robert van 't Sant
Bestuursbureau
r.van.t.sant@sea.leidenuniv.nl | +31 71 527 2727
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Single Cell
The single cell group (SCG) is part of the Metabolomics & Analytics Centre Our research is centered around developing innovating analytical methods tailored for small-volume, or single cell analysis to enable metabolomics-driven systems biology in personalized health strategies. We are always on…
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
- Cell Observatory
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T.P. Shoshkov
Science
t.p.shoshkov@umail.leidenuniv.nl | +31 71 527 5775
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T.E. Jaroszek
Faculty of Humanities
t.e.jaroszek.2@umail.leidenuniv.nl | +31 71 527 2031
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Cell Therapy
Decision support tool for cell therapy commercialization and business development
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Cancer cells: A closer look
What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Towards Biosolar cells
BioSolar Cells is a five-year research project in which ten knowledge institutions and 45 private industries work together.
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Stijn van 't Land
Faculty Governance and Global Affairs
s.w.van.t.land@fgga.leidenuniv.nl | +31 70 800 9500
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Maarten van 't Riet
Faculteit Rechtsgeleerdheid
m.van.t.riet@law.leidenuniv.nl | 071 5271571
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Maarten van 't Zelfde
Science
zelfde@cml.leidenuniv.nl | +31 71 527 5631
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Anna van 't Veer
Faculteit der Sociale Wetenschappen
a.e.van.t.veer@fsw.leidenuniv.nl | +31 71 527 1822
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses
Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.
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Nanowire based Tandem Solar Cells
In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.