1,358 search results for “global gene regulation” in the Public website
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Liver X receptor: therapeutic targeting of common pathways in Psoriasis and Cardiovascular co-morbidities
Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Research
The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Cryptic species discovery
Do understudied animals contain hidden species?
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Dutch contribution to the development of African countries in the global value chain
Economies worldwide are increasingly interconnected; trade in raw materials and semi-finished products is increasing. Many products we use in the Netherlands originate abroad, and many products we make in the Netherlands are destined for other countries. Almost all countries around us participate in…
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Liselore Tissen in Leiden Global on ‘bridging the gap between technology and the humanities’
External PhD Candidate Liselore Tissen was interviewed by Leiden Global about her work, in which she uses 3D printing. Recently she made a copy of a decorative human skill this way.
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Duke-Leiden Institute in Global and Transnational Law 2020: Call for Applications
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 14 June to 15 July 2020 in The Hague, the International City of Peace and Justice.
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No hunger, and not too much global warming? Current UN plan misses opportunities
The United Nations fall short in their recently published guide to address hunger without surpassing the 1.5-degree climate threshold. This initial version is a significant step, according to a group of researchers including those of Leiden University. However, they miss an essential topic: reducing…
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New study helps policymakers combat global warming with negative-emissions technology
Cutting down global emissions of greenhouse gases to combat global warming won’t do the trick alone: we also need negative-emissions technology that can capture carbon dioxide directly out of the air. In the prestigious journal Global Environmental Change, PhD candidate Oscar Rueda and colleagues shed…
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CRB1 gene therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
PhD defence
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Shepherding precision gene editing with CRISPR-Cas9 variants and adenoviral vectors
PhD defence
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How can local policies contribute to global sustainability goals?
The challenges of building a sustainable society are unprecedented. But the Dutch municipalities cannot be faulted for their commitment. They are working hard, conclude Professor Eefje Cuppen and Lian Merkx, programme manager for energy at the Association of Netherlands Municipalities (VNG). To exchange…
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India in the Making of the Global Esoteric: 1200-2000
On 15-16 June, Jos Gommans, Marieke Bloembergen, and Carolien Stolte will organize an international conference entitled “India in the Making of the Global Esoteric: 1200-2000”. The conference asks: why is it always India that has been imagined as a wonder, and what did that wonder mean, intellectually…
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for the Security and Stability of Cyberspace and their Impact upon Global Stability
On Thursday 2 May, the Institute of Security and Global Affairs (ISGA) of Leiden University hosted a guest lecture given by former NATO Assistant Secretary General for Emerging Security Challenges, Ambassador Sorin Ducaru.
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Department of Constitutional and Administrative Law well represented at Global Summit on Constitutionalism
The Global Summit on Constitutionalism took place from 16 to 18 March. Wim Voermans, Gert Jan Geertjes and Rowie Stolk, from the Department of Constitutional and Administrative Law, travelled to Austin where the conference was organised by the School of Law of the University of Texas at Austin.
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The Duke-Leiden Institute in Global and Transnational Law: Call for Applications 2019
The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 16 June to 17 July 2019 in The Hague, the International City of Peace and Justice. Applications for the second edition are now open!
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present their start-ups at final summit Innovation, Co-Creation and Global Impact
From a service stimulating intercultural contacts at work, to pet therapy against stress. An energizing table lamp reducing winter fatigue, and a website informing internet users on their rights. Thursday 24th of January, the student teams of FGGA minor Innovation, Co-Creation and Global Impact presented…
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Research and Education Grants in 2020 for the Institute of Security and Global Affairs
Whilst 2020 has been an unusual and taxing year for colleagues at the Institute of Security and Global Affairs (ISGA), the Institute nevertheless can look back on an impressive range of successful grant applications during the previous year. This impressive result was achieved on top of excellent results…
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Sustainability, Climate Change and Food ‘A full spectrum analysis of global society’
In September 2023 the new minor Sustainability, Climate Change and Food starts. This minor critically examines the complexities of food sustainability through ecological, socio-economic, political, and cultural systems.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Former student Aoife in Glasgow: 'I urged Rutte to limit global warming'
Aoife Fleming attended the climate summit in Glasgow as UN Youth Delegate for the Netherlands. She recently graduated with a master’s degree in Financial Law.
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Reading list - The Rise of China and the New Global Order
In the past half a century, China has transformed from an underdeveloped and inward-looking country to a major player in world politics. The country asserts itself more boldly on the world stage; not only in relation to nearby countries and places such as Taiwan, Japan, and other countries that share…
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Rural communities in the civitas Cananefatium 50-300 AD
This dissertation investigates the rural communities of the Cananefates in the period of 50 to 300 AD.
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Who is liable when damage is caused by Global Navigation Satellite System?
Who shall be responsible or liable when damage is caused by Global Navigation Satellite System (GNSS)? Is it fair enough to force a GNSS provider to bear the burden of compensation given GNSS open signals are provided free of charge? And are current international laws adequate to deal with those questions?…
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The first graduates of the Faculty of Governance and Global Affairs: LUC’s Class of 2015½!
LUC is the first to confer the diploma of the Faculty of Governance and Global Affairs, the new Faculty name since January 2016 making this graduation an extra special occasion.
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Faculty of Governance and Global Affairs hosts PROSEPS conference in The Hague
On Thursday 19 and Friday 20 September the PROSEPS conference took place in The Hague under the auspices of the Faculty of Governance and Global Affairs of Leiden University. During the two-day meet up, working group meetings and workshops took place in the New Babylon Conference Centre in the heart…
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Welcoming Three New Colleagues at Institute of Security and Global Affairs
We are pleased to welcome three new colleagues at the Institute of Security and Global Affairs this month: Andrea Bartolucci, Joana Cook and Silvia D'Amato.
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CfP Challenging the Liberal World Order: The History of the Global South, Decolonization and the United Nations, 1955-2000
On 8 and 9 May 2018 the Workshop 'Challenging the Liberal World Order: The History of the Global South, Decolonization and the United Nations, 1955-2000' takes place at Leiden University.
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The Governance of Complementary Global Regimes and the Pursuit of Human Security
Which challenges occur as a tool of sustainable peace in the emerging regime of international criminal justice? Andrea Marrone's study offers an overview. He will defend his thesis on the 28th October 2015.
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Vriesendorp and prof. Wessels included in the 2020 Lawdragon Leading Global Restructuring & Insolvency Lists
Prof. Vriesendorp and prof. Wessels have been recognized in the 2020 Lawdragon list of 500 Leading Global Restructuring & Insolvency Lawyers. Prof. Haentjens has been recognized in the 2020 Lawdragon Leading Global Restructuring Advisors & Consultants guide.
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Transatlantic Trade and Investment Partnership (TTIP): an EU perspective on global economic governance
On 4-5 December the Europa Institute and the Faculty of Governance and Global Affairs of Leiden University organize a conference on the Transatlantic Trade and Investment Partnership (TTIP).