355 search results for “type 2 diabetes” in the Public website
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Mapping Historical Leiden: A Dynamic and Digital Atlas (Phase 1 & 2)
The map application includes information from old and new buildings archaeological projects. This makes it possible to investigate whether water facilities (wells, cisterns) and waste facilities (cesspits, sewers) were the privilege of Leiden’s wealthy elite in the late 16th and 17th centuries or whether…
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Solutions for CRitical Raw materials - a European Expert Network 2 (SCRREEN2)
How can Critical Raw Material policies/strategies be enhanced in the EU context?
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2‐pyridylmethyl)amine Complex through a Stepwise Mechanism
The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…
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Two Bio-Pharmaceutical Scientists win KNMP Student Award
Two former Bio-Pharmaceutical Sciences students win the KNMP Student Award this year. Esmée de Zwaan for her research into new therapeutic strategies, Sanne Bakker for a study of bleeding risk associated with the use of antidepressant SSRI. Pharmacy organization KNMP awarded the annual prize on 8 October…
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infrastructure for science, technology and innovation policy studies 2
The European Research infrastructure for science, technology and innovation policy studies (RISIS2) aims at building a data and services infrastructure supporting the development of a new generation of analyses and indicators. To develop a deeper understanding of knowledge dynamics and policy relevant…
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Diagnosis and treatment of obese children with insulin resistance
Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst
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Biology student Martijn Verkuilen wins Unilever Research Prize
Martijn Verkuilen is the winner of the Unilever Research Prize 2022. By transferring DNA from a plant into yeast, he made the first move to produce a new drug for type 2 diabetes. He collected his prize in Wageningen on 24 November.
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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There is not one type of refugee
What is a refugee? This question might seem easy to answer, but it is not, concludes Catherina Wilson. For 7 years she did research in The Democratic Republic of the Congo near the Ubangi river, on refugees from the Central African Republic. The research shows that among refugees there exists a wide…
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Fighting diseases with good bacteria
Researchers from the Institute of Biology Leiden have discovered how good intestinal bacteria regulate our innate immune system. This surprising discovery could make it possible to treat diseases related to inflammation, such as diabetes and colitis, with a cocktail of good bacteria. Publication in…
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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Historical Perspective | Studies in Global Migration History, Volume: 13/2
In Migration and Membership Regimes editors Ulbe Bosma, Gijs Kessler and Leo Lucassen bring together ten essays in an analytical framework which looks beyond the Transatlantic migration of the nineteenth and twentieth centuries in a deliberate attempt to incorporate the experience of earlier periods…
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
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Sarantos Kostidis
Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands
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Partnership agreement with Indonesian Universitas Gadjah Mada ratified during visit
From student exchanges and a joint laboratory to heritage research and a knowledge consortium, the Indonesian Universitas Gadjah Mada (UGM) is in various respects an important partner for Leiden University.
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Live long and healthy
Leiden University will be 444 years old this year and is still very much alive and kicking. But how can we humans grow old healthily? Hanno Pijl at LUMC is the grand master of lifestyle medicine. He explains how we can all benefit from a sensible - but still enjoyable - lifestyle.
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…
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Frank Schaftenaar
Science
f.h.schaftenaar@lacdr.leidenuniv.nl | +31 71 527 5134
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Marc Baggelaar graduates cum laude on body’s own marijuana
PhD candidate Marc Baggelaar of the Leiden Institute of Chemistry (LIC) graduated cum laude on Thursday 6 April. His thesis on the endocannabinoid system in the brain is very comprehensive and of high quality, according to the jury. ‘A very talented young scientist, that definitely belongs to the top…
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26 million for research into the impact of non-genetic factors on health
Who will be affected by certain chronic diseases, and who will not? For 30 percent that depends on heredity factors, whereas no less than seventy percent is explained by external factors. A Dutch research consortium receives 18 million euros from the prestigious Zwaartekrachtsubsidies to study these…
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Typical representations of GL_n(F)
Promotores: Bas Edixhoven, Guy Henniart
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Ten thousand types of plant outgrowths bundled
For nine years he worked on the three-volume standard work Plant Galls of Europe. It yielded 2300 pages about 10,000 species of European galls, abnormal outgrowths in plants caused by parasites. Hans Roskam from the Institute of Biology Leiden: ‘The abundance of galls says something about the natural…
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Stephan Raaijmakers: 'Humans and systems have to learn to understand each other better'
You can ask virtual assistant Siri about the weather, but you can’t have a real conversation with it yet. You can’t refer to anything that’s been said before, or ask the system why it says what it says. Stephan Raaijmakers, Professor by Special Appointment from TNO, hopes to change this.
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Supercurrents gone chiral: new type of superconducting junction
Unconventional superconductors form one of the big mysteries in physics. Among them is strontium ruthenate, which stands out as a controversial superconductor. During his PhD, Leiden physicist Kaveh Lahabi has provided new insights into the nature of superconductivity in this material, leading to a…
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Career
The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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2 PhD Positions (Zürich)
The Chair of Medieval Latin (University of Zurich) invites applications for two PhD positions in the field of Medieval Latin. The positions are funded by the Swiss National Science Foundation (SNSF) as part of the project “Il mondo antico visto dalle glosse medievali”. Deadline: 31 December 2022.
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PhD position Université Lyon 2
The project IMAGINARM (Université Lyon 2) is looking for a PhD candidate to conduct research on illuminated manuscripts and their relation to Arthurian heraldic. The project is supervised by Francesco Montorsi (Université Lyon 2) and Martine Meuwese (Utrecht). Deadline for applications: May 31.
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Felix Wittleben
Science
f.t.wittleben@liacs.leidenuniv.nl | +31 71 527 1718
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SOURCE 2 SEA film premiere
LAPP was invited by the Plastic Soup Surfer to attend the premiere screening of SOURCE 2 SEA, a documentary following the Plastic Soup Surfer on his journey along the Rhine.
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Metabolic and Functional Evaluation of Diabetic Cardiomyopathy using MR Spectroscopy and MR Imaging
PhD defence
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Medical Biochemistry
Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.
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PEGASUS 2 Marie Skłodowska–Curie Fellowship
With 'PEGASUS 2', FWO aims to enhance human capital in fundamental research by attracting more excellent foreign researchers to Flanders via incoming fellowships, as well as by bestowing researchers in Flanders with increased international experience via outgoing fellowships.
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LUMC professor Maria Yazdanbakhsh receives Spinoza Prize
Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…
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Three new Leiden members of KNAW
KNAW has elected eighteen new members, including two professors at Leiden University and one who studied and obtained his PhD in Leiden. The New Academy members will be installed at a later date this year.
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Leiden research project on circular electronics receives 3.8 million euros from NWO
Fewer CO2 emissions, less airborne viral transmission, and a more sustainable form of food production: seven consortia of researchers and societal partners will put a budget of 32 million euros towards developing technological innovations. Important Leiden research on circular electronics by Prof. Dr.…
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Mosaic 2.0 scholarship for Rüya Akdağ
Rüya Akdağ is part of a research team with the aim of further studying social anxiety. The Leiden psychologist receives the grant for her doctoral research on the role of emotions and cognition in the emergence and occurrence of social anxiety in adolescents.
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Forging Global Citizens: Part 2
The Aernout van Lynden Global Citizenship Award award is a recognition given by the LUC community. Each year a student who has demonstrated the qualities of active engagement, responsive and responsible participation in civic and/or community building, within and/or beyond LUC is presented with the…