3,220 search results for “this week s discoveries” in the Public website
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
- Leiden Loves Science
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Brechtje Paijmans is 'Mr.' of the week
Since 1 November 2022, Brechtje Paijmans is endowed professor of Conflict Resolution and Legal Protection in Education. Dutch trade journal Mr. interviewed her about her appointment.
- YAL at Night of Discoveries 2023
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Make it an epic EL CID
This year a record number of students - more than 3,500 - will be taking part in the EL CID introduction week. Who are they and why did they opt for Leiden University? 'I want to get the absolute most out of my student time.'
- About this minor
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Knowledge for the public
Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.
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Ilyasse’s photo went viral: ‘It was quite a bizarre week’
It was meant as a joke for friends and family. A quick snap of him with his bags packed while watching the exit polls of the Dutch general elections. But the photo of our colleague Ilyasse El Boujadayni soon found its way around the entire country and before he knew it, he was being invited by national…
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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About the programme
Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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Datini 54th Study Week - Call for Research Papers
The Datini Institute has launched a call for research papers for its 54th Study Week (14-18 May 2023). Deadline for submission: 10 April 2022.
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Warm Sweater Day and Week of Sustainability 2020
Warm Sweater Day, February 7th & Week of Sustainability, February 10th-14th
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LED3 Lecture: Molecular glues in drug discovery
Lecture
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‘This mentor group will be their new family’
For many a first-year, student life has well and truly begun. This also applies to students in The Hague, who were thrown in at the deep end during the HOP introduction week. We paid them a visit on a sunny afternoon at Landgoed Clingendael.
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Curious Minds
At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Winner Physics Image Award is Volkskrant Image of the Week
Vera Meester has won the annual Physics Image Award 2016, with her photo of 'smiling' colloids. The Volkskrant published the picture as Image of the Week.
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Causal Discovery: Challenges and Opportunities
Lecture
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Successful third edition of Leiden University Academy Week
It was Leiden University Academy Week from 11 to 15 March. With over 300 sign-ups and a programme with 14 different webinars and workshops on our courses for professions, this edition was once again a resounding success.
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Bingo, barista and drinks: a successful We are Science Week
For three days, our faculty was all about We are Science Week: the community event full of fun activities for our staff and students. Besides the famous Beat the Professor PubQuiz, this year you could take USC yoga classes in the Gorlaeus garden, escape from Einstein's Escaperoom and sing along at the…
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Documentary From Aksum to India premiered during Week of Classics
For the annual Week of Classics, Dr Marike van Aerde and her team made a documentary about their research project Routes of Exchange, Roots of Connectivity. In the film the team touches upon the interactions of Greeks and Romans with the wider ancient world, ranging from the African kingdom of Aksum…
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The molecular secrets of medicinal cannabis
Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…
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‘New students, tomorrow's world needs you!
'Today is the start of EL CID, the first of three introduction weeks at Leiden University. A new influx of students is ready and waiting, eager to get started. Vice-Rector Hester Bijl warmly welcomes all new first-years. ‘Go for it and grab your chances!’
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CEEDs, the Collective Experience of Empathic Data Systems
The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
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Beyond the Site
The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Pascal chair 2023
Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Programme structure
The Drug Discovery and Safety specialisation consists of compulsory and optional components.
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Discovery of selective diacylglycerol lipase β inhibitors
PhD defence
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
PhD defence
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Discovery and characterization of new glucosylated metabolites
PhD defence