Computers are capable of making incredibly accurate predictions on the basis of machine learning. In other words, these computers can learn without intervention once they have been pre-programmed by humans. At LIACS, we explore and push the borders of what a revolutionary new generation of algorithms…

Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

Computers are capable of making incredibly accurate predictions on the basis of machine learning. In other words, these computers can learn without intervention once they have been pre-programmed by humans. At LIACS, we explore and push the borders of what a revolutionary new generation of algorithms…

Cambridge University Press has published a new book co-authored by researchers from Leiden University, offering both an introduction to machine learning and deep neural networks, and an overview of their applications in quantum physics and chemistry — from reinforcement learning for controlling quantum…

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

How to come to valid risk stratification of alcohol use disorder?

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

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We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Machine Learning is becoming a more and more substantial technology for industry.

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

PhD defence

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Cláudio de Sá predicted the preferences of people using rankings. He adjusted ‘classical’ machine learning approaches, making them suitable for predicting preferences. His work can be applied in the prediction of election results. PhD defence on 16 December.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

‘We hope our paper highlights the possibilities and benefits of including artificial intelligence in quantum physics to do new discoveries.’ Vedran Dunjko of the Leiden Institute of Advanced Computer Science contributed to a paper that was published in PNAS last year and now received a Cozzarelli Prize…

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

Friso Selten recently started a PhD position that is part of the SAILS program. This PhD project is a collaboration between FGGA, LIACS, and eLaw, and is supervised by Bram Klievink (FGGA), Joost Broekens (LIACS), and Francien Deschene (eLaw). In the project Friso will investigate the influence of artificial…

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.