This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Since the global COVID-19 pandemic, the coronavirus responsible (SARS-CoV-2) has been extensively probed for promising protein targets to establish drug-based therapies.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Roos van Oosten's research on medieval cesspits stood on the basis of an article on this subject in Quest Historie, a Dutch magazine about history.

This week Leiden student Roos Kolkman will be campaigning throughout the country to win the votes of Dutch youth in order to become the next UN Youth Delegate for Sustainable Development.

While studying Indonesian languages and cultures, Rennie Roos started a company. Today he has been working in Indonesia for more than eight years. Where does his love for this country come from? And how does he look back on his studies? ‘I actually wanted to become a pilot.’

PhD defence

Contraband and forced recruitment: How rebels' exploitation of natural resources can increase their willingness to forcibly recruit children.

The rise and fall of the cesspit in an urban context

The month of October saw LUGO host an active Green Morning to celebrate the opening of the largest green solar roof of the Benelux (located on the rooftop of the Snellius building!).

The APL (Analecta Praehistorica Leidensia) is published once a year and showcases the increasingly diversity of research conducted at the Faculty of Archaeology. The APL currently forms a showcase for the faculty as a whole in which all employees can publish their research. By alternatingly publishing…

Archaeological and Historical Perspectives on Eastern Cuisine and Western Foodways

PhD defence

We are proud to announce that the 1st Volume of INTER-SECTION is now available.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

This volume is themed around the interdependent relationship between humans and the environment, an important topic in the work of Corrie Bakels

Arie van Steensel and Ariadne Schmidt (eds.)

Osteoarchaeology is a rich field for reconstructing past lives in that it can provide details on sex, age-at-death, stature, and pathology in conjunction with the cultural, social, and economic aspects of the person’s environment and burial conditions. While osteoarchaeological research is common in…

This book is a celebration of the work of Professor Frans Theuws and was published in conjunction with the symposium held at the University of Leiden on June 29, 2018.

While the Netherlands was in lockdown because of the coronavirus, PhD candidate Koen Rijpkema began his research into the same virus. In the lab, he developed molecules that can inhibit an important viral enzyme.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

Are you a young researcher at Leiden University doing research on sustainability topics? Or are you part of the support staff and passionate about sustainability? Then we are looking for you!