The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

How do practice and theory reinforce one another in neuroscience? Professor Birte Forstmann’s inaugural lecture on 2 October will be about building interdisciplinary bridges between cognitive neuroscience and cognitive models. Her approach may lead to brain research with fewer side-effects for patie…

How do opinions form and change in large groups of people? That's not just a sociological question, it's a mathematical one. PhD candidate Federico Capannoli studied opinion dynamics. He defended his thesis on November 19.

External PhD candidate Liselore Tissen (Leiden University/Delft University of Technology) has been blogging on the Faces of Science website since March about her daily work as a researcher. ‘Academia is anything but stuffy.’

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

Early December, lecturer Joris Timmermans gave the first virtual reality lecture at the Institute of Environmental Sciences. Together with the Centre for Innovation, he developed an innovative teaching method for the master's course Methods in Biodiversity Analysis. The first results look promising.…

Five Leiden researchers have been awarded a Consolidator Grant by the European Research Council (ERC). This grant of up to two million euros will enable them to continue and expand their scientific research.

Elephants ranged over Schöningen in Lower Saxony 300,000 years ago. In recent years, remains of at least ten elephants have been found at the Palaeolithic sites situated on the edges of the former opencast lignite mine. Now, a collaboration of archaeologists from University of Tübingen and the Lower…

A mix of data research, artificial intelligence and archaeology led to lively discussions on 31 January. On that day the unique event 'AI & Data Science @ Archaeology' took place in which the Data Science Research Programme (DSRP), SAILS and the Faculty of Archaeology joined forces.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

The Physics and Quantum Matter and Optics specialisation is one of the two programmes Leiden offers in experimental physics. The programme can be tailored to individual needs and interests.

This master’s programme combines Physics with Data Science. You will learn how physics has its own tricks to deal with big data and how techniques from machine learning and deep learning can be applied to classical and quantum data. The first focus of attention is on classical data, including data mining,…

MRFM combines the principles of magnetic resonance and atomic force microscopy.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

This project aims to excavate and date the setting of the east gate of the Roman fortress of Udhruḥ. This will be compared with other Diocletianic military installations from the region. We also hope to retrieve another gate inscription which can shed light on the function and political embedding of…

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

Study of human cultures using computational approaches

Stephan Raaijmakers has been Professor of Communicative AI since 1 May. Prior to this, he had held this position for five years as professor by special appointment. How has his approach to AI changed in that time?

Modified viruses can both kill cancer cells and activate the immune system. This is what an LUMC team discovered while researching a new prostate cancer therapy.

The 2023 Digital Humanities Pilot Project Symposium and Digital Winter School took place, 30 Jan – 2 Feb 2023.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Professor of Computer Science Joost Batenburg has received half a million euros from the Dutch Research Council (NWO) to improve the conservation of historical paintings with 3D X-ray imaging.

External PhD Candidate Liselore Tissen was interviewed by Leiden Global about her work, in which she uses 3D printing. Recently she made a copy of a decorative human skill this way.

Lecture

Come to the Night of Discoveries art and science festival on 16 September. Various researchers from the university are speaking at the festival.

Should the background of the painting remain blue or be restored to its original gold colour? PhD candidate Liselore Tissen will be using 3D prints and eye-tracking software to answer this question. NICAS is giving her a grant of 18,000 euros to accomplish this.

From fake news via WhatsApp to mini hearts from a 3D printer: four Leiden researchers have been awarded a Consolidator Grant by the European Research Council. These grants, of up to 2m euros, enable researchers to establish or expand their research team and continue to develop their career.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.

She develops algorithms that outperform leading optimization techniques and can be applied in many fields. For this work, Niki van Stein and her team have won the GECCO Humies Award. ‘With our method, we can create and refine algorithms for a wide range of applications—algorithms that are better than…

Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…

Museum De Lakenhal is displaying the smallest work of art in the world: a 3D-printed statue of Rembrandt van Rijn, made by sculptor Jeroen Spijker and researchers from Leiden University.

Making all those things we normally cannot see visible is the challenge that fascinates Fons Verbeek, Leiden's new Professor of Computational Bio-Imaging. Contributions from chemistry, optics and in particular computational sciences to making and processing these images give greater insight into the…

It was the Night of Discoveries on Saturday 16 September: a summer encounter between art and science. Leiden researchers from various disciplines inspired the public with their quest to understand our world.

Milan van der Kuil, Anne Visser, Andrea Evers and Ineke van der Ham have published a paper in Frontiers in Psychology, entitled: A usability study of a serious game in cognitive rehabilitation: a compensatory navigation training in acquired brain injury patients.

PhD defence

The ISSC's ICT helpdesk receives dozens of questions from staff and students every day. A collaboration between TNO, LUCL and the ISSC aims to determine whether a specially designed chatbot could provide support in this area.

LUCDH Lunch Lecture