The Agent Based Modelling for Archaeologists (ABMA) project is dedicated to developing Open Educational Resources (OERs) and accompanying materials for agent-based modelling (ABM) in Archaeology.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Promotor: Prof.dr. H.A.G. Wijshoff

In this project we investigate how the professional development around the theme of inquiry based teaching of teachers from three international schools takes place.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Om de verkeersveiligheid te kunnen waarborgen en overlast in de binnenstad tegen te gaan, wil de gemeente Enschede als eerste gemeente in Nederland een verbod op fatbikes invoeren. Geerten Boogaard, hoogleraar decentrale overheden, zegt in RTL-nieuws vraagtekens te hebben bij de juridische haalbaarheid…

On Friday morning, 18 October, Rector Magnificus Hester Bijl and Professor Remco Breuker welcomed Korea Foundation President Gheewan Kim.

Dr. Pauline Aarten onderzoekt welke impact een verkeersongeval heeft op slachtoffers en nabestaanden en hoe we de positie van deze mensen kunnen verbeteren.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Reijer Passchier, universitair docent Staatrecht in Leiden en hoogleraar Digitalisering en de democratische rechtsstaat aan de Open Universiteit, pleit voor de ontwikkeling van europese techbedrijven, waarbij europa zijn soevereiniteit weet te behouden. Hij waarschuwt vooral niet het ‘destructieve gigantisme-model…

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Towards a framework that integrates content-based and process-based accounts of mathematical thinking

Promotores: Wim Jiskoot; Ferry Ossendorp

Access to information is a human right (United Nations, 1948). Information technology, such as search engines and recommender systems, has become the key mediator and facilitator to connect people to information (White, 2016). Conversational artificial intelligence (AI) technology is increasingly being…

The living plant collections form the heart of the Hortus botanicus Leiden and serve as a vital resource for scientific research. By studying these collections, researchers can explore biodiversity in a unique way and conduct experiments on living material.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Corporate R&D organizations and their relation to academic laboratories.

To what extent can contingent, formative feedback in lectures, facilitated by web-based ICT, increase students’ self-efficacy and (academic, behavioral, and cognitive) engagement? And how are self-efficacy and engagement influencing students’ performance and course evaluations?

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

This thesis describes the design, characterization and application of dextran based crosslinked network.

Duizenden metaalvondsten die door detectorzoeker wijlen Herman Zomerdijk zijn gedaan in de regio Kennemerland schetsen een uniek beeld van Noord-Holland door de eeuwen heen. Hij zocht en verzamelde decennialang historische metalen objecten in Noord-Holland en bouwde zo een unieke metaalcollectie op.

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Lecture

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Toen in 2019 honderden afvalcontainers in de Waddenzee vielen, wilde de overheid geen informatie vrijgeven over wat er in de containers zat. Vijf jaar later weten we eindelijk meer, nadat hoogleraar Esther Kentin beroep deed op de Wet Open Overheid.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This research proposal focuses on the investigation of the poetic potentials of negativity through the exploitation of failure in sound based artistic practices - a context that has not been extensively addressed.

On Tuesday 7 September 2021, the new Faculty year was opened with the Leiden Law Op 1 Talkshow. Various guests shared their thoughts and expectations for the new academic year. Lotte Kremers and Bastiaan Rijpkema presented the show.

De rechtbank van Rotterdam geeft zorghulp Carol Kollmann gelijk in haar rechtszaak tegen het UWV. De zorghulpverlener vond dat ze recht heeft op een WW-uitkering en het meetellen van haar arbeidsverleden voor de WW, nadat ze erachter kwam dat ze daar door de zogeheten Regeling dienstverlening aan huis…

In navolging van Duitsland en het Verenigd Koninkrijk, wil de ministerraad een nieuw wetsvoorstel, om verheerlijking van terrorisme en steunbetuiging aan terroristische organisaties strafbaar te stellen. Wim Voermans, hoogleraar Staatsrecht, duidt de zaak in Dagblad Trouw.

On Thursday and Friday, 1 and 2 March 2018, ICCL students and staff enjoyed a study trip to Brussels, including visits to the Permanent Mission of the Kingdom of the Netherlands, the European Commission and top law firm De Brauw Blackstone Westbroek.

De Europese Commissie is van mening dat de EU-beschermingsclausule (art. 42.7 EU-verdrag) van toepassing is, wanneer de VS Groenland zou annexeren. Experts, waaronder hoogleraar europeesrecht, Armin Cuyvers, zeggen in het Noord-Hollands Dagblad, het hier niet mee eens te zijn, omdat het in deze kwestie…