For present purposes, it is important to distinguish between an early period of settlement, about 6800-6200 BC, and a late period, about 6200-5800 BC, at Tell Sabi Abyad.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.

The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

DIGIFOOD is a transnational research project that investigates how data governance can support equitable and sustainable digital food systems. Around the world, digital technologies are transforming agriculture. Sensors in soil, satellites in space, and mobile phones in farmers’ hands are generating…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

This research tries to create a coherent comprehension of misfit, enhance conceptual knowledge, highlight prevalent knowledge.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

An important hormone excreting gland in the human body is the pituitary

Uncovering task solving processes in dynamic testing

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

What are the conditions under which coercive diplomacy can compel a State to abandon its nuclear weapons program?

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

On Friday 7 March 2025 Adam Knight successfully defended a doctoral thesis and graduated.

Promotores: W. Jiskoot, F. Ossendorp