569 search results for “genome organisation” in the Public website
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DNAmarkerpoint
The main purpose of DNAmarkerpoint is to better understand the ecology, evolution and biodiversity through the study of ancient- and modern DNA.
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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Biodiversity & Evolution
Evolutionary and ecological interactions affect species on genetic and phenotypic levels. This theme aims to understand these processes at multiple levels: from molecules to genomes to populations and to communities. Our research focuses on evolutionary responses to anthropogenic change, the role of…
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Research themes
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.
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Biomedical Sciences Research
The Biomedical Sciences research specialisation aims to provide you with a theoretical background and academic competences in multidisciplinary research in Biomedical Sciences. The entire programme is taught in English.
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Research
The members of LUXs develop and validate new methods and algorithms for analysing data, and apply these in a wide range of problems. Their research ranges from multidisciplinary applications to proving mathematical theorems.
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Cremation in the Early Middle Ages
Death, fire and identity in North-West Europe
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Key publications
Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)
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Biomedical Sciences Health
The Biomedical Sciences Health specialisation aims to provide you with a theoretical background and academic competences in multidisciplinary research in Biomedical Sciences and in clinical practice in Medicine. Since the programme is partly taught in English and partly in Dutch, fluency in Dutch is…
- Publication highlights
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Combinatorial testing of viral vector and CRISPR systems for precision genome editing
PhD defence
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Resolving a bioindicator diatom species complex using genomic approaches for freshwater biomonitoring
PhD defence
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Soft genome editing based on CRISPR nickases: it takes one break to tango
PhD defence
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
PhD defence
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Fire and Human Evolution
Despite the field’s general agreement that pyrotechnology had a significant impact on the cultural evolution of humankind, our understanding of the origins and development of fire use and its role in humankind’s cultural evolution is very limited, blurred by strong disagreements over its chronology…
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Tracking the Tocharians from Europe to China: a linguistic reconstruction
This project intends to provide an integrated linguistic assessment of the hypothesised migration route of the Tocharians.
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Mysteries in snake venom evolution
A new analysis of the king cobra genome by Michael Richardson, Christian Henkel (IBL) and collaborators at the IBL and Naturalis, Helsinki and Singapore has been published in
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Xi’an Jiaotong University Day at Leiden University
16 April was a special day at the Faculty of Science. In honour of the collaborations with the Chinese partner university, it was declared Xi’an Jiaotong University Day.
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Kraft Lab - Self-assembly in Biological and Soft Matter
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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Research
Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.
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PhD Theses
A full overview of MacBio PhD Theses.
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Science
The Faculty of Science
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Leiden University Medical Center
The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Bacteria full of potential: searching for new antibiotics through genetic on–off switches
Collaborating and learning from other fields – that is what bioinformatician Hannah Augustijn enjoys most about doing research. During her PhD at Leiden University, she developed new ways to search within bacteria for the antibiotics of the future.
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
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Why Biomedical Sciences at Leiden University?
The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.
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Leiden Professor convenes precision medicine workshop at Harvard's Radcliffe Institute
Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.
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Break-through in the genetic modification of plants
A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…
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New IBL-professor in "Computational Biology": Vera van Noort
Vera van Noort has been appointed Professor in the field of Computational Biology within the Faculty of Science at the Institute of Biology from the 1st of February 2017. Van Noort’s expertise is in bioinformatics and her research focuses on the computational analysis of large-scale biological data…
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Biophysicists unravel exact folding of a single gene
The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.
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Whole genome sequencing and contact screening in the surveillance and infection control of methicillin and borderline oxacillin resistant Staphylococcus
PhD defence
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and neoplastic B cells: From AID- induced diversification to genome-wide patterns
PhD defence
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‘Look beyond your own discipline’
Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.
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Phyto-pharmaceuticals and gene targeting
We exploit secondary metabolites of plant to develop pharmaceutical compounds and we genetically modify plant genomes to improve crops.
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The bite that heals: New antibiotics with help from venomous animals
Prof. Gilles van Wezel and Prof. Mike Richardson of the Institute of Biology Leiden received €1.4 million to find new antibiotics.
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New STW-grant to redirect the plant micro biome: “Back to the Roots”
Professors Jos Raaijmakers (NIOO) and Gilles Van Wezel (IBL) received an STW Perspectief- grant of €3 million from the Dutch Technology Foundation and several supporting companies.
- Medicine / LUMC
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Michael Richardson in TV show Willem Wever about antibiotics from snake venom
'What do people do with snake venom?' That's the question 11-year-old Joep asked in Dutch TV show Willem Wever. Leiden Professor of Evolutionary developmental zoology and snake venom expert Michael Richardson answers the question in his laboratory.
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Traces of indigenous "Taíno" found in present-day Caribbean populations
A thousand-year-old tooth has provided genetic evidence that the so-called
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Supergenes make bizarre traits possible
Within the same species of butterfly many different wing patterns can occur. How is this possible? According to researchers Ben Wielstra and Emma Berdan, of the Institute of Biology Leiden (IBL), the answer lies within supergenes. A supergene is a part of a chromosome that contains many strongly linked…
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Richard Karlsson Linnér: ‘I expect a future where a genetic test will be as much a no-brainer as getting X-rayed.’
Assistant Professor Karlsson Linnér, who works at the Department of Economics, is one of the recipients of a Veni grant. His research on the accuracy of preventive genetic testing is a fine example of the intersection of economic science and law.
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Guus Kroonen publishes article in Science Magazine
Alongside several other authors, Guus Kroonen, University Lecturer in Linguistics, published an article in the well-renowned academic journal Science Magazine. The article,