An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.

Political scientists Joop van Holsteyn and Tom Louwerse (Leiden University) find that the Dutch government is having a hard time coping with referendum outcomes in general, and ‘anti-European’ sentiments among voters in particular.

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

A new therapy for the serious Graft-versus-Host disease

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists from Delft University of Technology and Leiden University developed a technique that speeds up screening…

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

Find out how to apply for Transfusion Medicine and Cellular and Tissue Therapies.

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Political scientists Tom van der Meer, Lisa Janssen (University of Amsterdam) and Tom Louwerse (Leiden University) analyse polls presented by the main polling agencies in the Netherlands, as well as micro-level panel data. They reach three main conclusions. First, vote intention polls in the Netherlands…

Ten Leiden social and behavioural scientists have successfully applied for the NWO Open Competition. With this Open Competition, NWO gives researchers the chance to start small, high-risk, innovative or promising research projects.

Professor emeritus of Animal Behaviour Carel ten Cate is awarded honorary membership by the Dutch Society for Behavioural Biology (NVG). He received the honour for his activities for the Society and the discipline of behavioural biology.

Study information

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Strengthening a cancer patient's own immune system so that the body itself can better destroy cancer cells. This is at the heart of immunotherapy, the most promising progress in cancer treatment in recent years. In order to drive this development further, the Netherlands Cancer Institute-Antoni van…

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Cynthia van Vonno, political scientist at Leiden University, explains why individual MPs vote according to the party group line.

The Dutch Research Council (NWO) has awarded a grant of €2,858,000 from the Dutch National Research Agenda (NWA) for tackling sexually transgressive behaviour and sexual violence (SGOG). Mischa Dekker, assistant professor and member of the Violence and Violence Prevention research group, is a co-applicant…

Professor P.F. (Paul) Wouters has been appointed dean of the Faculty of Social and Behavioural Sciences with effect from 1 January 2019. Wouters has been appointed for a period of three years and succeeds Professor Hanna Swaab, whose second term of office as dean expires this year. Swaab will remain…

It is sufficiently plausible that the professor from the Faculty of Archaeology exhibited the ‘inappropriate and unacceptable behaviour’ detailed in the advice of the investigating committee. That is is unless the professor provides counter-evidence. This is the conclusion of the Subdistrict Court…

A professor from Leiden University, together with a former employee (who is also the professor’s partner), has been guilty of long-term unacceptable and often transgressive behaviour in the form of abuse of power and manipulation. This behaviour led to a culture of fear among staff who were largely…

In memory of Andrea Evers, Professor of Health Psychology, the Prof. Andrea Evers Fund for Health, Behaviour and Society has been established. With this fund, we aim to honour her deepest wish: to continue research that contributes to health, well-being, and a resilient society.

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

A research into how people eat and drink during their daily routines, and the circumstances under which these activities take place.

This article by Danielle Goldwert, Sara Constantino, Jaroslaw Kantorowicz and colleagues presents one of the largest behavioral 'megastudies' to date, testing how different interventions can stimulate public, political and financial climate advocacy.

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

Does a drug enter into the human brain once administered in the body?

The electrochemical reduction of a group of organic compounds on platinum is strongly dependent on the arrangement of the atoms in the platinum surface. Christoph Bondue, postdoc in Marc Koper's group, published this in Nature Catalysis on 4 March. The reduction of such compounds is an important process…

Health psychologist Andrea Evers has been invited by several Dutch and international media to talk about the coronavirus and the measures taken by the government with regard to public health.

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

A therapeutic vaccine against HPV-16 (type 16 human papillomavirus) improves the survival rate in cervical cancer patients. A new study by ISA Pharmaceuticals B.V. (a Leiden-based biotechnology company) and the Leiden University Medical Center (LUMC) shows that this vaccine produces a more robust response…