How to access the end-of-supply risk of spare pares using big data analytics

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Today, 189 out of 193 officially recognised nation-states have a written constitution, and 75% of these have been ratified since 1975. How did this worldwide diffusion of constitutions come about?

Visual art played an important role in the development of cooperative human behaviour. This is the finding of Larissa Mendoza Straffon, a PhD candidate in archaeology, whose dissertation explores the biological and psychological foundations of visual art.

Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.

People in the Early Bonze Age used bronze artefacts as a means of payment. This is the conclusion reached by archaeologists Maikel Kuijpers and Catalin Popa in a PLOS ONE article published on 20 January.

Although sugars are widely used in biological and medical research, their synthesis is still badly understood. Jeroen Codée has received a Vici grant of 1.5 million euros for systematically studying the production of sugars. ‘I want to genuinely understand the reactions.’

An international team of astronomers has published the most sensitive images of the Universe ever taken at low radio frequencies, using the International Low Frequency Array (LOFAR). ‘LOFAR is unique in its ability to make high-quality images of the sky at metre-wavelengths’, said Huub Röttgering, Leiden…

Cultural Anthropology and Development Sociology

It is difficult to imagine a society other than a hierarchical nation-state. This is in part because we neglect alternative forms from the past, argues archaeologist Lewis Borck in the Journal of Contemporary Archaeology.

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

It all started with demonstrations protesting about the death of George Floyd from police brutality in Minneapolis, but the Black Lives Matter protest is spreading like wildfire across the whole of the US. Every day, thousands of people are taking to the streets. We asked American Studies expert Sara…

Prisoners who have little or no contact with the outside world are more prone to reoffend. What makes visits so important?

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

This PhD project investigates the different ways in which honorific forms are used in Japanese other than to express politeness, and how different factors affect perceptions about these uses.

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

For this project we delve into children's digital media use during the transition from kindergarten to group 3 and investigate its impact on their social development.

We talk too little about silence, thinks university lecturer Gerlov van Engelenhoven. He has been awarded a Veni grant to investigate the role of silence in protest movements. Does silence sometimes really say more than a thousand words?

Has there been continuity or change in US counterterrorism policy since 9/11? What factors led to the continuity or change, and how do we classify any such continuity or change?

On December 18th, Viktorija Kostadinova succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Viktorija on this great result.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Promotor: Prof.dr. G.R. de Snoo

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

In this article, Eamon Aloyo argues that university supervisors should not use student evaluations of teachers as a measure of teaching effectiveness.

This dissertation aims to explore how university students use mobile technology for their self-directed language learning and investigate factors influencing their self-directed learning with mobile technology.

How did people experience Islam on a day-to-day basis in the early centuries of Islam? That's where the papyri come in, says professor of Arabic Petra Sijpesteijn in the fourth video of the Leiden | Islam interview series.

This dissertation is concerned with the study of the less than twenty remaining precolonial Mesoamerican codices. By considering these rare and fragile pictographic and hieroglyphic books from the cultural biography perspective, many different aspects of these books can be studied.

The archaeology domain produces large amounts of texts, too much to effectively read or manually search through for research. To alleviate this problem, we created a search system (called AGNES), which combines full text search with entity and geographical search.

A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.

Adoptees in the Netherlands generally do not use more medication than their non-adopted peers.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The transition period in which men become fathers might provide an important window of opportunity for parenting interventions that may produce long-term positive effects on paternal care and, consequently, child development. Existing prenatal programs traditionally focus on maternal and infant health…

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

This research strand centers on the relations between cultural expressions and time.

In her “Jews and Judaism” lecture class, Dr. Sarah Cramsey’s students produced 7-minute long podcasts instead of final papers.

In her “Jews and Judaism” lecture class in Fall 2020, Dr. Sarah Cramsey’s students produced 7-minute long podcasts instead of final papers.

An international team of astronomers, including Leiden’s Christian Ginski, has discovered previously unobserved structures in a debris disk around a nearby star. Article published in Nature on 8 October.

The many thousands of small celestial bodies beyond Neptune’s orbit may have ended up there due to a star that passed close to the solar system billions of years ago. This is shown by Leiden simulation expert Simon Portegies Zwart, along with his German and Dutch colleagues. ‘We are answering several…

Dutch people are far more law-abiding than they might like to think. And they are very different from the Belgians in that regard. The different approaches of the two governments towards the coronavirus crisis, for example, can be explained from the history of both countries since the Middle Ages. Historians…

On 22 August was the start of the HOPweek, the introduction week for first year students studying at Campus The Hague of Leiden University. First year students were assigned to their own group with their own mentors. During this week the students could do fun activities and workshops where they got…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.