In this research note, Van der Does & Kantorowicz aruge that citizens that tend to experience political exclusion are often more supportive of direct and participatory forms of decision-making.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

In 'The Spirit of Matter', Peter Pels explores the significance of emotionally evocative objects, challenging the denial of their existence in modern 'mind over matter' ideology.

Promotor: K.H. Kuijken

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

On the 13th of November, Yifei Bi successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Yifei on this achievement.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Chapter by Fabio Cristiano and Emilio Distretti for the volume The Aesthetics and Politics of the Online Self, edited by Donatella Della Ratta, Geert Lovink, Teresa Numerico, and Peter Sarram for Palgrave Macmillan.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

This study examined the effects of a classroom-focused intervention on different domains of early literacy. The intervention consisted of shared e-book reading combined with a print referencing technique done via a SMART board. The specific goal of the study was to examine whether children could be…

Violence during war often involves upswings and downturns that have, to date, been insufficiently explained. Why does violence at a particular point in time increase in intensity and why do actors in war decrease the level of violence at other points? Duyvesteyn discusses the potential explanatory variables…

On 1 October 2020, Arianne de Leeuw defended her thesis 'Scheiding van zeggenschap en belang in de familiesfeer'. The doctoral research was supervised by Prof. F. Sonneveldt and Prof. A.O. Lubbers.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Chair of LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University - the Netherlands

The article examines how Southern European member states' newspapers portray European irregular migration governance.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

OPERA aims at establishing open and advanced research analytics practices and systems at Danish universities and in the Danish landscape of research analytics stakeholders.

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

Promotor: J.M. Memelink

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

How do we address the pressing challenges posed by large-scale networks?

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

PhD defence

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Professor Joke Bouwstra has been elected as member of the Koninklijke Akademie van Wetenschappen (KNAW, The Royal Dutch Academy of Sciences). This is a very prestigious recognition and a great honor for Joke. You can find the announcement by the KNAW below (short version) and as an attachment.

Leiden University is a centre of migration research, bringing together historians, economists, lawyers, political scientists and anthropologists. They conduct research on who migrates and why, and the impact on societies. They analyse government policy, the role of media and how societies respond to…

Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

How have human-environmental entanglements changed in the Gulf of San Miguel, Darien, Panama, from the first traces human practices through to the present?

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

Under what circumstances is politicization more likely to occur than others, and what impact does politicization have on government legitimacy and performance?

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.

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What is the Electronics Department?

Leiden University has long history of research and teaching on Asian traditions, with a focus on language and philology, history, religious studies, philosophy, law and literature. Leiden has in the last thirty years also built up an equally impressive strength in the study of modern and contemporary…

The Chair Democratic Representation in the Kingdom focuses on the political relations between the ‘European’ Netherlands and the six Caribbean islands in the Kingdom; so-called Kingdom Relations. Professor Wouter Veenendaal investigates the quality of democratic representation in the Kingdom, both within…

Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.