In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Over the past decade, several novel types of spatially resolved

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…

A piece of corrugated rubber can function as a simple computer, displaying memory and displaying the ability to count to two. Leiden physicists describe the computing rubber in the journal PNAS. ‘Simple materials can process information, and we want to find the principles behind that.’

Master Computer Science in Leiden nr.1 according to Elsevier

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

The worldwide race to the quantum computer is in full swing. This computer can bring about a breakthrough in discovering medicines and new materials. Leiden researchers, together with the TU Delft, are taking part in the race. There is now a dossier online about their work.

American physicist and quantum computing pioneer Seth Lloyd is the 65th Lorentz professor. He will deliver the Ehrenfest lecture on 5 June, and several more lectures on quantum computing on 11, 18 and 25 June.

Leiden University and the Beijing Institute of Technology will be collaborating in the area of computer science teaching and research. One of the first outcomes of this collaboration will be a joint four-year bachelor's programme. Willem te Beest, Vice-President of the Executive Board, and Professor…

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

An international committee has assessed computer science research at all Dutch universities in the period 2009-2014. For its computer science research, Leiden was awarded the ‘highest’ mark (1) for relevance to society.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Leiden prof. emeritus Grzegorz Rozenberg is honoured with the first life time award in formal languages, a research area of theoretical computer science. During a small ceremony at his house, he received a statue that was specially made for the occasion.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Computer applications and quantitative methods in archaeology CAA95.

Affective Computing (AC and sometimes called ‘Emotional AI’) provides opportunities to automatically process emotional data. However, is EU data protection law fit for purpose when it is applied to such AC approaches?

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

Simulating human language understanding on the computer is a great challenge. A way to approach it is to represent natural language meanings in logic, and to use logical provers to determine what does and does not follow from a text. What logic is best to use and how natural language meanings are best…

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

In online games conflicts between players may arise. Novin, Bos, Stevenson and Rieffe investigated factors that may explain why some adolescents react more angrily than others in this type of situation. In their realistically designed gaming environment, the (pre-programmed) fellow player suddenly started…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Please note that the course Molecular Biology for Physics will start on Monday 5 February. Please check the schedules for the time and location!

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

In a world first, an international team of researchers has read an unopened letter from Renaissance Europe – without breaking its seal or damaging it in any way. Nadine Akkerman, Reader in early modern English literature at Leiden University, is co-author of the article that appeared on 2 March in Nature…