Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Martijn Ridderbos has been reappointed vice-chairman of the Executive Board of Leiden University by the Board of Governors.

To log into many university systems you now need to use Multi-factor authentication (MFA). This means that as well as entering your username and password, you also need to confirm your identity via an additional method.

igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…

Stam defended his dissertation ‘Freedom of speech and the suppression of discrimination in the Netherlands: a constitutional-developmental approach’ on 12 November 2025. The doctoral research was supervised by Afshan Ellian and Bastiaan Rijpkema

A defining fixture of our contemporary world, video games offer a rich spectrum of engagements with the past.

What is the significance of the history of slavery for our present-day society? A special exhibition in the inner courtyard of the Academy Building features eleven insightful portraits of students and staff, and their answer to this question. The aim of the exhibition’s initiators is to make the subject…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Polarisation in our society is on the rise. What makes people increasingly radical? How do we protect ourselves from extremist, terrorist or criminal threats, be they physical or in the cyber world? And what role do intelligence services play in this?

This project sets out to map, document and analyze instances of squatting in Leiden from 1970 to 1990, in order to set up an online Digital Archive of Squatting in Leiden. This archive will function as an online resource for academic research, as well as a starting point for public activities such as…

Annetje Ottow, president of the Executive Board of Leiden University, has been the new chair of the Leiden-Delft-Erasmus (LDE) strategic alliance for just two months. What does she want to achieve during her two-year chairmanship?

Leiden University has set up two committees to consider issues that are the focus of much attention within our community and society at large. They are the Knowledge Security Committee and the Fossil Fuel Industry Collaboration Committee. Former dean Joanne van der Leun will chair both.

On Tuesday a few dozen students and staff from Leiden University protested on the square in front of the Lipsius building against the classroom scanners that have been installed in buildings and lecture halls. They are demanding that the scanners be removed.

The Dies Natalis for alumni on 11 February was an online event. Almost 1,000 alumni tuned in to Bastiaan Rijpkema’s interview with Annetje Ottow, who had then been President of Leiden University’s Executive Board for all of three days. Alumni are part of her portfolio on the Executive Board.

Leiden University consists of seven faculties, each managed by a dean.

Are you interested in one of our vacancies? To get to know each other well, we follow a number of steps in the application process.

When you have finished your dissertation, it is time to prepare for the defence procedure.

The Leiden Centre for Continental Philosophy (LCCP) is a research community based at the Institute for Philosophy at Leiden University. LCCP is envisaged as an open space for stimulating discussion, critical debate and inventive co-operation in the local and international philosophical community. We…

Medewerkers van de Universiteit Leiden trappen maandag 10 maart de estafettestaking af van de Nederlandse universiteiten tegen de kabinetsbezuinigingen.

Leiden University contributed to colonialism and slavery through its research and teaching. And governors and residents of Leiden had an active role in colonial networks. These are the findings of two explorative studies presented on 3 April.

Video conferencing from your sitting room and algorithms on social media that know your interests: new technology is an increasingly integral part of our lives. At the same time there is a growing call to protect our privacy, and this is causing friction, at the University too. In part because of the…

Policy studies and interventions in the field of Youth

Find out how to apply for Air and Space Law programme at Leiden University by following our step-by step guide.

Old Observatory, Sterrenwachtlaan 11, 2311 GW, Leiden

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

When you finish your dissertation, it must undergo a plagiarism check via IThenticate.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Old Observatory, Sterrenwachtlaan 11, 2311 GW, Leiden

Find out how to apply for North American Studies at Leiden University by following our step-by step guide.

Find out how to apply for Religious Studies at Leiden University by following our step-by step guide.

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Find out how to apply for the MA Advanced Studies Law and Digital Technologies at Leiden University by following our step-by step guide.

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Find out how to apply for Russian and Eurasian Studies at Leiden University by following our step-by step guide.

Find out how to apply for International Financial Law at Leiden University by following our step-by step guide.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

This case study demonstrates how to design and effectively deploy a (survey embedded) conjoint experiment.

This timely and engaging book examines the rise of populism across the globe. Combining insights from linguistics, argumentation theory, rhetoric, legal theory and political theory it offers a fully integrated characterization of the form and content of populist discourse.

Unmanned aerial vehicles (UAVs), often referred to as drones, have become easy and inexpensive to buy, and it is generally expected that the use of drones by private individuals, businesses and public authorities will increase tremendously in the coming years. This raises questions as to what is technologically…

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Global Challenges is the research programme of the Leiden Institute of Cultural Anthropology and Development Sociology.

Fundamental research in the ALgebra, Geometry And Number Theory