In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

An overview of our infrastructure at the SPP division:

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Following the conference of the 20th Austrian European Law Day in September 2021 at the University of Liechtenstein in Vaduz, the academic papers of the conference have now been published in book form. The book contributions include a chapter by Christa Tobler: Christa Tobler, 'Finally Brexit - Alternative…

An enormous number of monumental buildings, such as burial tombs, appeared in Mycenaean Greece after 1600 BC. Why did this urge to build come to an abrupt end 400 years later? Archaeologist Ann Brysbaert investigates the possible causes thanks to her ERC Consolidator Grant.

Brain activity changes as people age, which can lead to cognitive decline. By measuring and comparing brain data from mice and humans, the researcher will investigate how the brain’s noise levels change with age and affect choice behavior.

By making smart use of available data, the health and care of people can be substantially improved. Marco Spruit wants to use language and machine learning in the coming years to identify and solve the biggest care issues in the region of The Hague. He has been appointed Professor of Advanced Data Science…

Suzan Verberne has been appointed professor of Natural Language Processing at the Leiden Institute of Advanced Computer Science (LIACS) from 1 October. Verberne has been at LIACS since 2017 as group leader of the Text Mining and Retrieval group.

Are AI models such as Midjourney violating artists' copyright? Dirk Visser, Professor of Intellectual Property Law, spoke about this topic on Dutch current affairs news programme 'NOS Radio 1 Journaal' .

As of this month, Kim Bonger has been appointed Professor of Chemical Biology. As a first-generation academic, she’s especially grateful. ‘I wasn’t exactly a top student at school. I never could’ve imagined this.’

An X-ray scanner, some small metal balls, and a newly developed algorithm. That is all you need to make a 3D model that enables you to look inside art objects without dismantling them. Thanks to the research of Francien Bossema (Centrum Wiskunde & Informatica and Leiden Institute of Advanced Computer…

Prof.dr.ir. Hai-Xiang Lin is appointed on 1 March 2015 as part-time professor on Data Analytics for Environmental Modelling at CML on behalf of the R. Timman foundation. He will join the CML-department of Industrial Ecology. He has a position at the Department of Applied Mathematics at the Faculty…

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

This thesis is based on five papers on several topics.

The imaging group focuses on bio-imaging, image analysis and visualization.

Promotor: M. Ubbink, Co-promotor: G. Siegal

A 90+ seat room in the LUMC Main Building. Rolling, flexible, tables on a carpetted floor allows for the quiet re-arrangement of the room to support teaching in groups of many size. Nearly 3 full walls are covered in magnetized, writable surfaces, and there are hinged TVs on the walls which can be beamed…

Just like the professional riders from the Jumbo-Visma team, amateur cyclists will soon be able to analyse and improve their performance. Leiden data scientists working with the cycling team are making their smart data model available so that every serious cyclist can keep track of their fitness.

Data from 41 million galaxies does not shake up the standard cosmological model after all. To that conclusion, to their own surprise, comes an international team of researchers including Koen Kuijken, professor at the Leiden Observatory.

Biodiversity and trade: mitigating the impacts of non-food biomass global supply chains.

Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

A passion for video games, visuals and science: it almost seems impossible to bring all of this together. Yet, scientific animator Vera Williams found that dream combination at NeCEN's microscopy lab. 'An image or animation can help clarify the content of complex research.'

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Where did species survive the cold cycles of the current Ice Age?

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

The project aims to conserve and consolidate the entrance gate to the Roman Desert Frontier Fort Qasr Bshir.

How can photorealistic 3D scenes help predict whether interventions in urban public spaces will foster citizens' sense of security?

The 2019 Model ICAO took place from 21-24 May at the ICAO headquarters in Montreal.

Research lines within the Pharmacy group:

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Venture capital investors Zeeuws Investerings Fonds and Participatiemaatschapij Oost Nederland have joined forces with national and regional partners to fund development and sales of MIMETAS’ unique 3D disease- and tissue modelling technologies.

Researchers from Leiden University Medical Center (LUMC) and the Leiden-based biotech company Ncardia have joined forces to develop a new platform that enables the automated production of 3D cardiac microtissues. This platform will allow large numbers of drugs to be tested quickly

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

High throughput microscopy

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotor: H.J.M. de Groot

Can smart suggestions help translators work better with machine translation? As machine translation becomes the norm, professional translators are asked to correct its output; a process called post-editing. But how can we make this easier and more effective?

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.