This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Leiden academics Remco Breuker and Auke-Florian Hiemstra stand to win the title of Person of the Year.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

450 years

PhD defence

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. G.P. van Wezel

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…

PhD defence

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Lecture

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

On May 20th, Joost de Moor took part in a panel that examined what is (not) unique about the recent waves of climate mobilization, as well as the question of engagement with or opposition to formal global sustainability governance institutions.

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

PhD defence

PhD defence

PhD defence

PhD defence

Lecture

Lecture

Tumours act like mini-organs, manipulating their environment and using bodily processes to survive and metastasise. Through research by Erik Danen and his colleagues, we are learning more about the complex nature of tumour cells. In the Dutch newspaper NRC, the scientists discuss their findings.

PhD defence

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Lecture

How small steps can lead to big change: that was the theme of the Leiden Education Festival. Students and lecturers came to Scheltema on 9 May to share their experiences of educational innovation.

SALTSWAT -- a project which combines the Spaces for Active Learning & Teaching and the Support wtih Active Teaching -- began in Mid-2019 and is running in pilot until the summer of 2020. The purpose of the project is to find answers to the question of how to systematically accelerate 'active teaching…

Below are resources which provide a short primer on the subject of active learning.

Getting started with active learning & teaching can be as simple as assessing on what is already accomplished. Here are some practical courses of action to begin experimenting with active learning, whether you are a teacher or responsible for the spaces.

Learning analytics tracks students’ online learning activities in order to support their learning. But what if most of their learning takes place offline, out of sight of digital eyes?

The Faculty of Science has multiple study associations, which organise both study-related and social activities for students.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Four different astronomical societies are active in the Old Observatory. We are very proud of the commitment these associations show to organize activities.

Leiden student life offers many opportunities to discover and develop your talents. You can become active in a study or student association; participate in various study committees and boards; gain work experience in a side job or an internship. And in your free time, there is plenty to do: Leiden is…

This project aims to provide evidence-based knowledge on the conditions for successful anti-corruption activism in Ukraine.