This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Estudio arqueológico de la primera ciudad española en la Tierra Firme de América: Santa María de la Antigua del Darién

Trajectories of social life in the yucayeque (community) of El Cabo, Higüey, Dominican Republic, AD 800 to 1504

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

Spaanse Water

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

Current status and future prospects

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Microwear and starch grain analysis on experimental and archaeological grinding tools from Central

Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016

This publication brings together two contributions born of different intentions but which are both dedicated to Hellenistic pottery of the Alexandria region.

We prepare you for your career. We will provide you with knowledge and professional skills to navigate the complex world of digital technologies.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Mari Nakamura defended her thesis on 14 March 2017

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Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The funerary textile tradition from the Osmore Valley, South Peru, and its social-political implications (2005)

Through extensive archaeological and documentary research, this study aims to provide a detailed analysis of the maritime cultural landscape of St. Eustatius over the past four centuries. It focuses on bridging the gap between the marine and terrestrial worlds and demonstrates that in order to truly…

This research combines archaeological, archaeometric and ethnohistorical research to study the organisation of settlement space and residence rules among the Taino Indians during the Late Ceramic Age (AD 1000-1492).

FIJI is one of the most used image analysis tools in the world. FIJI stands for FIJI is just ImageJ, it is however much more.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

The thesis explores micromammal fossils from the Afşar section in Anatolia, a crucial locality for understanding the Pliocene epoch and the transition to the Villafranchian Age.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

The programme encourages engagement career preparation activities, like offering guest lectures and a study trip. Read more about the career activities

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

The Pontine Region Project (PRP) is an on-going archaeological project that aims to study the long-term history of settlement and landscape in the Pontine region

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

We prepare you for your career by adressing the legal issues that impact the rights of children across the globe. Read more information about career preparation

Do you have any questions about the bachelor's programme Linguistics? Don't hesitate to contact us!

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The Great Rift Valley in Africa is a real treasure trove for discovering early human fossils. The fossils found in this part of Africa have determined our view of human evolution. But was the Great Rift Valley really the place where evolution took place or just a place where fossils are well preserved…

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Insights in diet, climate and ecology

We highly advise you to register with a GP in Leiden or The Hague before arrival or soon after you get here.

This research comprises various sub-projects.

Bioarchaeology covers the study of all biological remains from archaeological sites.

Work on the buildings for the Faculty of Humanities is continuing. Planning has begun for a modern, future-proof education building on the site of the current Reuvens building. The new education building is scheduled for completion in mid-2031.

Pastoralist Societies, Rock Art and Literacy in Jordan’s Black Desert (200 BC to 800 AD)

Sinds september 2010 werken Geerten Waling en Anne Heyer in het NWO project ‘The Promise of Organization’.

A vibrant chronological narrative of ceramic manufacturing practices in the valley of Juigalpa, Chontales, Nicaragua (cal 300 CE - present)

This project aims to answer the following questions: how did the landscape and geography of the local surroundings of Chalcis impact medieval to early modern productivity, habitation, mobility and interaction in a wider sense? And where are such changes and continuations still visible in the landsca…

PhD Research Projects at LUCDH and Affiliated Faculties

This article explores levels and patterns of legitimacy beliefs with respect to multistakeholder global governance at ICANN. From a large and systematic evidence base, Jongen & Scholte have found that ICANN has strong legitimacy underpinnings among its staff and board, as well as quite uniformly moderate-to-high…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel