The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

The research group Corporate Governance and Strategy investigates how, with whom and for whom a firm/corporation creates/captures value, in order to inform practice and rule makers about governance issues. By focusing on the dual character of the firm as an entity by itself but also consisting of stakeholders,…

In our new strategic plan (Innovating and Connecting – 2022-2027) we focus on stronger connections: between disciplines, with society and within our university community.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Blended and hybrid teaching are presented as crucial in promoting teaching innovation, as well as more flexible study approaches allowing students to develop their own tailor-made study programmes. While the strategy document focuses on the positive aspects of digital teaching tools, no systematic study…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

What does our faculty stand for and what will we do in the next five years? We are proud to present our new strategic plan that we made together. On this website you will find more information about what our Faculty stands for and what our course is for the coming years

The focus of health care is rapidly changing. The need for maximum gains with minimal input requires tailored health care strategies and an ever more explicit evaluation of health benefits for the patient.

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

PhD defence

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

To what extent and in what manner can experimental video be used to reclaim the capacity for telling one’s own story, on one's own terms, speaking in tongues outside the linguistic framework of immune system discourse?

The minor Creative Strategies for a Society in Change (CSSC) makes a connection between gaining insight into creative processes and exploring social issues that characterize our time.

Natural product inspired antibiotics to address resistance

Few events have influenced our global order as intensely as the events of September 11, 2001.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

This research hopes to contribute to social awareness of the consequences of colonialism for Indigenous Peoples, to the deconstruction of still existing colonial and discriminatory notions and to a better appreciation of Indigenous art and thought.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

A comparative analysis of legitimation strategies in tree hybrid regimes: Russia, Venezuela, and Seychelles.

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

In Europe, archaeological traces of fire become more frequent between 300,000 and 400,000 years ago; but could the earliest occupants have survived without fire for at least half a million years before this? How could the early occupants of Europe have kept warm and processed meat without fire?

Social aspects of the learning environment, also called classroom climate, are important for students’ cognitive and affective learning outcomes. In this thesis the classroom climate is operationalised by means of two components: the teacher-class relationship and classroom discipline.

Article by Annemarie Samuels in History and Anthropology

The main question I want to answer is about the mutual influence between the cultural and settlements changes that occurred between the Bronze and the Early Iron Age in Margiana and the management of water resources.

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

In The Agency of Empire: Connections and Strategies in French Expansion (1686-1746) Elisabeth Heijmans places directors and their connections at the centre of the developments and operations of French overseas companies.

Agriculture is among the most vulnerable sectors to climate change and poorer countries face the most severe difficulties. Coffee farmers in Central America, for instance, are facing multiple and mutually reinforcing crises, including price shocks, outbreaks of pests and diseases, migration, and farm…

Our previous meta-analysis (Swart et al., 2019) had shown that feedback targeting text comprehension given when students perform a reading task positively influences learning from text. So far, differences in the effects of feedback were explained by design features, such as the timing and richness…

From ca. 1540 to 1600, thousands fled the war-stricken Southern Low Countries to the British Isles, Germany, and the Northern Low Countries. Research on this displacement crisis, central to the formation of the Netherlands and Belgium, reflects 21st-century debates on migration and language: language…

This study presents the findings of a laboratory-based experiment testing hypothesised processes implicated in the prevention of violent radicalisation through counter-narratives. The central aims of the study were to contribute to counter-narrative theory, whilst highlighting the value of experimental…

This project aims to provide evidence-based knowledge on the conditions for successful anti-corruption activism in Ukraine.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

What are the key technical, social, regulatory, economic, and ethical considerations for scaling up ocean-based Carbon Dioxide Removal (CDR) approaches, and what integrated assessment frameworks and governance structures are needed to facilitate their implementation at scale?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…