1,062 search results for “optimize drug design” in the Staff website
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Award for a method that can create even better algorithms
She develops algorithms that outperform leading optimization techniques and can be applied in many fields. For this work, Niki van Stein and her team have won the GECCO Humies Award. ‘With our method, we can create and refine algorithms for a wide range of applications—algorithms that are better than…
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Thomas Bäck and Hao Wang new Editors in chief of the Evolutionary Computation Journal
LIACS scholars Thomas Bäck and Hao Wang will be the new Editors-in-Chief of the Evolutionary Computation Journal from November 1. Published by MIT Press since its foundation in 1993, the journal stands as a keystone in the field, providing a global platform for researchers exploring the workings of…
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To what extent does your background and your own physical consciousness influence your experience in VR?
Neuroscientists Ineke van der Ham (Leiden University) and Anouk Keizer (Utrecht University) regularly use VR in their research. Their experiences with the medium raise many questions about the ways VR is experienced by different people. Therefore they conducted an VR experiment at the cinedans festival…
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Willem van der Does sheds new light on the at times pitch-black history of psychiatry
Piercing through the skull with an ice pick, administering electric shocks without an anaesthetic, or applying leeches to the uterus: these may seem like medieval methods of torture, but they are in fact therapies used in medicine. Willem van der Does writes about all of them in his new book. ‘Physicians…
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Back to the scanner: brain science in times of corona
For their research many neuropsychologists use the brain scanners at the LUMC. At the start of the pandemic, the rules for visiting the hospital became stricter and a large amount of psychology research looked as though it would fall through. Thanks to good protocols the researchers can now pick up…
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Erik Danen new Dean of the Graduate School of Science
The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.
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Introduction to entrepreneurship
On the 8th of March the first "introduction to entrepreneurship" boot camp was held at PLNT specifically for PhD researchers at the LACDR. During the two hour block topics such as "the core of entrepreneurship", "spotting opportunities" and "what is your value proposition" were discussed.
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Towards translation of CNS pharmacokinetics from mice to men
PhD candidates Mohammed Saleh and Berfin Gülave (Division of Systems Pharmacology and Pharmacy) published their research paper on “Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice”.
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Symposium: A Dutch Perspective on Mycobacterial Infections
On March 24, 2025, World TB Day, we (Annemarie Meijer (IBL), Matthias Barz (LACDR), and Simone Joosten (LUMC) hosted the symposium „A Dutch Perspective on Mycobacterial Infections“, which brought together the Dutch scientific community working on mycobacterial infections.
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Daan Jiskoot wins the Suzanne Hovinga Award 2024
During the LACDR Fall Symposium, Daan Jiskoot received the annual Suzanne Hovinga Award for the best master thesis. Daan performed his Research Project 2 at the University of California, Irvine at the Prof. David Mobley lab, supported by LACDR supervisor Willem Jespers. The in silico determination of…
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Douwe D. Breimer Research fund
Prof. dr. Douwe Breimer, emeritus Professor of Pharmacology, former Rector Magnificus and founder of LACDR has established a foundation to stimulate, support, and promote scientific meetings in the field of Pharmacology. Particularly those concerned with fundamental research and mathematical modelling…
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The future of artificial intelligence
From self-driving cars to innovative drug development, artificial intelligence (AI) is going to fundamentally change our lives in a variety of ways.
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LACDR Fall Symposium 2021
On Thursday the 9th of December the LACDR Fall Symposium 2021 took place. Although the plan was to organize this symposium physically, unfortunately this was not possible due to the corona measures and it became an online event.
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Niek Kijk in de Vegte wins the Suzanne Hovinga Award 2023
During the LACDR Fall Symposium, Niek Kijk in de Vegte received the annual Suzanne Hovinga Award for the best master thesis. Niek performed his RP1 research under the supervision of Dr. Natalia Ortiz Zacarias and Prof.dr. Laura Heitman in the Molecular Pharmacology group at the Division of Drug Discovery…
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Beyond iced coffee and face masks: ‘True self-care is about emotional awareness and living according to your values’
In hun klinische stage leren Psychologiestudenten mentale steun bieden aan anderen, maar hoe zorgen zij als toekomstige therapeut ook voor zichzelf? Met video’s, podcasts en een panel wil Kelly Ziemer haar studenten de nodige zelfzorg-skills bijbrengen.
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What makes our university strong and distinctive? Let your voice be heard!
What sets Leiden University apart from other universities? And what research themes would you like us to showcase to the outside world? Share your ideas in our online consultation over the next two weeks.
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Race against time: Helping the Netherlands secure almost 20 million Pfizer vaccines
The whole world is waiting anxiously for sufficient supplies of coronavirus vaccines. As Launch Navigator at Pfizer, alumnus Dennis de Mik must help ensure that the Netherlands receives 19.8 million doses of the Pfizer/BioNTech vaccine. How is he going about this and how has his Bio-Pharmaceutical Sciences…
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Eleven Open Competition Domain Science XS grants for Leiden researchers
Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make software faster and greener, improve cancer detection and reduce anxiety by manipulating the biological…
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Psychologists at Lowlands Science: can virtual reality trigger a psychedelic experience?
Fantastic plants, dizzying patterns and pulsating sounds: researchers from Leiden are going to study the effects of a simulated psychedelic trip on the mind and body at Lowlands Festival. Why might this be interesting for therapies?
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A lifeline for Leiden research – TB solution a step closer thanks to this Indonesian university
Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…
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New SPARXS technique reveals DNA behaviour at unprecedented speed
Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists from Delft University of Technology and Leiden University developed a technique that speeds up screening…
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On barriers and bridges: autoimmune rheumatic diseases and the road to a cure
Hans Ulrich Scherer is Professor of Rheumatology, in particular Translational Rheumatology. He wants to build bridges between research and clinical practice and between departments and organisations at home and abroad. Scherer will give his inaugural lecture next Friday. ‘To make progress, we have to…
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New study helps policymakers combat global warming with negative-emissions technology
Cutting down global emissions of greenhouse gases to combat global warming won’t do the trick alone: we also need negative-emissions technology that can capture carbon dioxide directly out of the air. In the prestigious journal Global Environmental Change, PhD candidate Oscar Rueda and colleagues shed…
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‘The gatekeepers’ van het internet; waarom een ‘gratis’ internet niet bestaat
Of je nu appt, online nieuws leest, of door Instagram scrolt, jouw gedrag wordt gemonitord. Sterker nog: wát jij ziet, wordt door anderen bepaald. Promovendus Aleksandre Zardiashvili onderzocht de impact van online advertenties en de macht van de bedrijven erachter.
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Autistic children develop social-emotional skills with other children
Autistic children have indeed potential: most of their emotional abilities improve with age, concludes developmental psychologist Boya Li in her research on the emotional development of autistic children. Promotion on 10 November 2021.
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Protoplanetary discs are much smaller than previously thought
Many protoplanetary discs in which new planets are formed are much smaller than thought. Using the Atacama Large Millimeter/submillimeter Array (ALMA) scientists of the Leiden Observatory looked at 73 protoplanetary discs in the Lupus region.
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Adapt or perish – traits identified that help plants survive
PhD candidate Jianhong Zhou aimed to better understand whether and how plant species adapt to environmental changes. She developed two databases that she used to analyze how easily or difficultly plants adapt to changing conditions. Zhou defended her PhD thesis on 4 September.
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New treatments for life-threatening disease sepsis
Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.
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How a pathogenic bacterium searches for food
Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.
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First comprehensive study on gun violence in Europe identifies alarming trends
The steady decline in lethal gun violence in the EU came to halt in 2012 and some countries, such as Sweden, have even noticed an increase since then. An arms race among drug criminals and an increase in the availability of illegal firearms could lead to more criminal and gun violence. This is one of…
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Multiple KHMW awards for science students
As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…
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Three NWO Open Competition grants for Leiden scientists
Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.
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Gerard van Westen wins KNCV Gold Medal
Gerard van Westen has received the KNCV Gold Medal, the most important Dutch award for chemists under 40. 'It's a huge honour,' says the professor of AI and medicinal chemistry. 'I am now part of the group of people I was always impressed by.'
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Modified caffeine molecules help medical research move forward
Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.
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Building the best possible mini-liver (without making it too complex)
How do organs work in the body, and how can we create mini-organs to study diseases and test new medicines? That’s the idea behind organ-on-a-chip technology. During his PhD, Flavio Bonanini worked on developing the best possible mini-livers. ‘Make them as simple as possible, and as complex as neede…
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In Memoriam - associate professor Hans Brussee
On 15 April, our much-beloved and highly respected former colleague Dr Hans Brussee passed away from cancer. In January 2025, Hans began experiencing neck pain. Initially, it appeared to be a herniated disc, but sadly, the diagnosis was soon revised, and his condition proved untreatable. Hans was 77…
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From liquid to solid: revolutionary technique uncovers disease-related changes in tiny droplets within our cells
Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…
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NWO-XS grants for two innovative research projects
Two Leiden Science researchers received an NWO-XS grant for their research. Both projects are highly promising, but also high-risk. Macrophages that trap bacteria and data storage made from 2D materials convinced the board of their potential.
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European grants for research on ultrathin membranes and the biological clock in bacteria
Two research groups involving Leiden University have been awarded a major European grant, the ERC Synergy Grant. This for research on the development of membranes that can clean water and purify medical drugs and research on the biological clock in certain bacteria.
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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‘A few nerves before lectures show that my work matters’
Giving an incorrect answer as a student in a packed lecture hall can be nerve-wracking. But with Pharmacology teacher Rob van Wijk, you don’t need to worry about that. ‘He creates a comfortable and safe atmosphere,’ his students say. They have nominated him for the Leiden Science Teacher Award.
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The career choices of cells
How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.
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Reliable research with virtual patients
The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…
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In memoriam: Dr. Daniëlle A. Hamstra
On July 28, 2022, our dear colleague Daniëlle Hamstra passed away after a short sickbed. Daniëlle had been associated with the Clinical Psychology Section since 2010, initially as a student in the research master's program and subsequently as a lecturer and PhD candidate.
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LACDR Strategy Day: Shaping Our Future Together
On March 20, our institute held a highly engaging Strategy Day, bringing together colleagues to discuss key topics for LACDR with respect to governance, team collaboration, and career paths. The day was marked by insightful debates, interactive activities, and opportunities for informal exchange, all…
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Special nanoparticles for cancer therapy! Will you help?
Developing a better treatment for patients with head and neck cancer, that is what Binanox, The 2022 iGEM Leiden team, want to achieve. They hope to raise at least 10,000 euros for this cause. Support their crowdfunding campaign today.
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New Horizons in Physics prize for Sebastiaan Haffert: ‘Very honoured’
‘The Oscars of the natural sciences’, is what they are called: the Breakthrough Prizes awarded annually in America by the Breakthrough Foundation. Part of this are the New Horizons prizes for early-stage researchers. Sebastiaan Haffert, researcher at the Observatory, is this year's winner.
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Honours students consult on real-life cases in course on Public Leadership Consulting
It is not always easy for students to apply their academic knowledge in practice and get acquainted with the work environment of professional public organisations. Public organisations may struggle in turn to successfully address leadership challenges in their current way of working.
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Anja Rüten-Budde wins the C.J. Kok Jury Award for best thesis
Statistician Anja Rüten-Budde has won the C.J. Kok Jury Award 2020. Her PhD thesis resulted in an app which helps patients with soft tissue sarcoma and their doctors to make well-considered choices about the treatment. ‘Her work is interdisciplinary and directly relevant for society,’ the jury state…
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Eleven master’s students start research into sustainable hospitals
February 8 saw the launch of the Medical Delta ‘Sustainable Hospitals’ Interdisciplinary Thesis Lab. The research projects will touch on different aspects of healthcare. The students hope they will be able to offer practical solutions to make hospitals greener.