Piercing through the skull with an ice pick, administering electric shocks without an anaesthetic, or applying leeches to the uterus: these may seem like medieval methods of torture, but they are in fact therapies used in medicine. Willem van der Does writes about all of them in his new book. ‘Physicians…

During the LACDR Fall Symposium, Niek Kijk in de Vegte received the annual Suzanne Hovinga Award for the best master thesis. Niek performed his RP1 research under the supervision of Dr. Natalia Ortiz Zacarias and Prof.dr. Laura Heitman in the Molecular Pharmacology group at the Division of Drug Discovery…

Prof. dr. Douwe Breimer, emeritus Professor of Pharmacology, former Rector Magnificus and founder of LACDR has established a foundation to stimulate, support, and promote scientific meetings in the field of Pharmacology. Particularly those concerned with fundamental research and mathematical modelling…

On the 8th of March the first "introduction to entrepreneurship" boot camp was held at PLNT specifically for PhD researchers at the LACDR. During the two hour block topics such as "the core of entrepreneurship", "spotting opportunities" and "what is your value proposition" were discussed.

During the LACDR Fall Symposium, Daan Jiskoot received the annual Suzanne Hovinga Award for the best master thesis. Daan performed his Research Project 2 at the University of California, Irvine at the Prof. David Mobley lab, supported by LACDR supervisor Willem Jespers. The in silico determination of…

The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.

On Thursday the 9th of December the LACDR Fall Symposium 2021 took place. Although the plan was to organize this symposium physically, unfortunately this was not possible due to the corona measures and it became an online event.

From self-driving cars to innovative drug development, artificial intelligence (AI) is going to fundamentally change our lives in a variety of ways.

PhD candidates Mohammed Saleh and Berfin Gülave (Division of Systems Pharmacology and Pharmacy) published their research paper on “Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice”.

On March 24, 2025, World TB Day, we (Annemarie Meijer (IBL), Matthias Barz (LACDR), and Simone Joosten (LUMC) hosted the symposium „A Dutch Perspective on Mycobacterial Infections“, which brought together the Dutch scientific community working on mycobacterial infections.

The whole world is waiting anxiously for sufficient supplies of coronavirus vaccines. As Launch Navigator at Pfizer, alumnus Dennis de Mik must help ensure that the Netherlands receives 19.8 million doses of the Pfizer/BioNTech vaccine. How is he going about this and how has his Bio-Pharmaceutical Sciences…

The nominees for the IRO Thesis Prize 2024 and the Prof. Dr. J.Th.J. van den Berg-prijs 2024. Who authored the best thesis in Leiden University’s bachelor’s programme in Political Science?

Leiden researchers have developed a groundbreaking model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumours with immune cells during…

Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists from Delft University of Technology and Leiden University developed a technique that speeds up screening…

Hans Ulrich Scherer is Professor of Rheumatology, in particular Translational Rheumatology. He wants to build bridges between research and clinical practice and between departments and organisations at home and abroad. Scherer will give his inaugural lecture next Friday. ‘To make progress, we have to…

Fantastic plants, dizzying patterns and pulsating sounds: researchers from Leiden are going to study the effects of a simulated psychedelic trip on the mind and body at Lowlands Festival. Why might this be interesting for therapies?

The steady decline in lethal gun violence in the EU came to halt in 2012 and some countries, such as Sweden, have even noticed an increase since then. An arms race among drug criminals and an increase in the availability of illegal firearms could lead to more criminal and gun violence. This is one of…

Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.

Two research groups involving Leiden University have been awarded a major European grant, the ERC Synergy Grant. This for research on the development of membranes that can clean water and purify medical drugs and research on the biological clock in certain bacteria.

Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.

Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.

Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.

Giving an incorrect answer as a student in a packed lecture hall can be nerve-wracking. But with Pharmacology teacher Rob van Wijk, you don’t need to worry about that. ‘He creates a comfortable and safe atmosphere,’ his students say. They have nominated him for the Leiden Science Teacher Award.

The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…

Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.

On July 28, 2022, our dear colleague Daniëlle Hamstra passed away after a short sickbed. Daniëlle had been associated with the Clinical Psychology Section since 2010, initially as a student in the research master's program and subsequently as a lecturer and PhD candidate.

Two Leiden Science researchers received an NWO-XS grant for their research. Both projects are highly promising, but also high-risk. Macrophages that trap bacteria and data storage made from 2D materials convinced the board of their potential.

Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…

How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.

Gerard van Westen has received the KNCV Gold Medal, the most important Dutch award for chemists under 40. 'It's a huge honour,' says the professor of AI and medicinal chemistry. 'I am now part of the group of people I was always impressed by.'

How do organs work in the body, and how can we create mini-organs to study diseases and test new medicines? That’s the idea behind organ-on-a-chip technology. During his PhD, Flavio Bonanini worked on developing the best possible mini-livers. ‘Make them as simple as possible, and as complex as neede…

As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…

On 15 April, our much-beloved and highly respected former colleague Dr Hans Brussee passed away from cancer. In January 2025, Hans began experiencing neck pain. Initially, it appeared to be a herniated disc, but sadly, the diagnosis was soon revised, and his condition proved untreatable. Hans was 77…

Last November, Dr. Natalia Ortiz, Martijn Bemelmans (MSc), and Prof. Laura Heitman published a review in Trends in Pharmacological Sciences (TIPS) on targeting the chemokine system in cancer (https://doi.org/10.1016/j.tips.2021.08.001). The review was written in collaboration with Prof. Tracy Handel…

The European Food Safety Authority (EFSA) has awarded a €1.6M contract to an LACDR-led consortium to assess how sensitivity to toxicity caused by chemicals varies among individual people. Currently these toxicodynamic differences are an unknown source of uncertainty when carrying out risk assessment…

Research

Eleven researchers of the Faculty of Science are on the 2021 Highly Cited Researchers list of Clarivate Analytics. Only 0.1 per cent of researchers are included in this list, literally making them one in a thousand.

On 25 May 2024, our much-loved former colleague prof.dr.dr.h.c.mult Hans E. Junginger passed away.

Natalia Ortiz (Division of Drug Discovery and Safety) has been awarded the 2019-2020 PhD-thesis prize by the Division of Medicinal Chemistry & Chemical Biology, from the Royal Netherlands Chemical Society (KNCV-MCCB). The KNCV-MCCB thesis prize is a biannual award which is granted to the best PhD thesis…

Rob van Wijk (LACDR, Leiden University) and Robin van den Biggelaar (LUCID, LUMC) have been awarded a €10,000 euro KIEM grant from Leiden University to start an interdisciplinary collaboration to investigate the potential of AMPK activation as an adjunctive therapy to enhance tuberculosis treatment.

We are congratulating Maaike van der Lee, PhD candidate at LUMC-KFT, for winning the national PhD competition 2021 at the FIGON Dutch Medicine Days. During this national competition, 8 researchers from the major university cities in the Netherlands present their work in the field of innovative medicine…

During the LACDR Fall Symposium the Suzanne Hovinga Award for ‘best master thesis’ was awarded to Carlijn Lems for her master thesis entitled ‘Elucidating the crosstalk between epithelial-to-mesenchymal transition and Programmed Death-Ligand 1: validation and extension of a computational model’. Carlijn…

On Friday 2 June 2023, Vincent Delhomme, Assistant professor at the Europe Institute at Leiden Law School, successfully defended his PhD thesis entitled : ‘Regulating lifestyle risks in EU law: Promoting health in a diverse market’.

Ad IJzerman, Emeritus Professor of Pharmacochemistry, was made a Knight of the Order of the Lion of the Netherlands on 26 April. He was presented with the royal honour by Mayor Elbert Roest in the town hall in Bloemendaal.

Instant messaging app Telegram is not faring well in the news – the reason being the illicit activities occurring on the platform. Professor Bart Custers helped Dutch current affairs programme ‘EenVandaag’ respond to questions about the platform.

How can we diagnose the life-threatening condition sepsis in premature babies as quickly and accurately as possible? That is what PhD student Manchu Thangavelu from the Leiden Academic Centre for Drug Research (LACDR) wants to figure out.

Education

PhD