920 search results for “hybrid drug” in the Staff website
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New treatments for life-threatening disease sepsis
Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.
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First comprehensive study on gun violence in Europe identifies alarming trends
The steady decline in lethal gun violence in the EU came to halt in 2012 and some countries, such as Sweden, have even noticed an increase since then. An arms race among drug criminals and an increase in the availability of illegal firearms could lead to more criminal and gun violence. This is one of…
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Multiple KHMW awards for science students
As many as seven first-year students from the Faculty of Science were honoured as young talents. In addition, the Royal Holland Society of Sciences and Humanities (KHMW) also lauded three master's students and an astronomy project during a vibrant ceremony on 28 November. Professor of Science Communication…
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Three NWO Open Competition grants for Leiden scientists
Smart drug carriers, uneven cosmic expansion, and solar energy storage in molecules. These are the topics of three newly awarded NWO-XS grants to researchers at the Faculty of Science.
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Gerard van Westen wins KNCV Gold Medal
Gerard van Westen has received the KNCV Gold Medal, the most important Dutch award for chemists under 40. 'It's a huge honour,' says the professor of AI and medicinal chemistry. 'I am now part of the group of people I was always impressed by.'
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Modified caffeine molecules help medical research move forward
Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.
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Building the best possible mini-liver (without making it too complex)
How do organs work in the body, and how can we create mini-organs to study diseases and test new medicines? That’s the idea behind organ-on-a-chip technology. During his PhD, Flavio Bonanini worked on developing the best possible mini-livers. ‘Make them as simple as possible, and as complex as neede…
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In Memoriam - associate professor Hans Brussee
On 15 April, our much-beloved and highly respected former colleague Dr Hans Brussee passed away from cancer. In January 2025, Hans began experiencing neck pain. Initially, it appeared to be a herniated disc, but sadly, the diagnosis was soon revised, and his condition proved untreatable. Hans was 77…
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From liquid to solid: revolutionary technique uncovers disease-related changes in tiny droplets within our cells
Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…
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NWO-XS grants for two innovative research projects
Two Leiden Science researchers received an NWO-XS grant for their research. Both projects are highly promising, but also high-risk. Macrophages that trap bacteria and data storage made from 2D materials convinced the board of their potential.
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European grants for research on ultrathin membranes and the biological clock in bacteria
Two research groups involving Leiden University have been awarded a major European grant, the ERC Synergy Grant. This for research on the development of membranes that can clean water and purify medical drugs and research on the biological clock in certain bacteria.
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In memoriam: Dr. Daniëlle A. Hamstra
On July 28, 2022, our dear colleague Daniëlle Hamstra passed away after a short sickbed. Daniëlle had been associated with the Clinical Psychology Section since 2010, initially as a student in the research master's program and subsequently as a lecturer and PhD candidate.
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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‘A few nerves before lectures show that my work matters’
Giving an incorrect answer as a student in a packed lecture hall can be nerve-wracking. But with Pharmacology teacher Rob van Wijk, you don’t need to worry about that. ‘He creates a comfortable and safe atmosphere,’ his students say. They have nominated him for the Leiden Science Teacher Award.
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The career choices of cells
How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.
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Reliable research with virtual patients
The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…
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How a pathogenic bacterium searches for food
Bacteria whirl around in the mouths of most people, forming dental plaques and sometimes causing nasty gum infections. Treponema denticola might be a dangerous pathogen, but not much is known about this bacterium. It was up to Ariane Briegel and her research group to change that.
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Carlijn Lems wins the Suzanne Hovinga Award 2020-2021
During the LACDR Fall Symposium the Suzanne Hovinga Award for ‘best master thesis’ was awarded to Carlijn Lems for her master thesis entitled ‘Elucidating the crosstalk between epithelial-to-mesenchymal transition and Programmed Death-Ligand 1: validation and extension of a computational model’. Carlijn…
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Royal honour for emeritus professor Ad IJzerman
Ad IJzerman, Emeritus Professor of Pharmacochemistry, was made a Knight of the Order of the Lion of the Netherlands on 26 April. He was presented with the royal honour by Mayor Elbert Roest in the town hall in Bloemendaal.
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Remarkable PhD research: diagnosing sepsis in premature babies
How can we diagnose the life-threatening condition sepsis in premature babies as quickly and accurately as possible? That is what PhD student Manchu Thangavelu from the Leiden Academic Centre for Drug Research (LACDR) wants to figure out.
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Review on “Anticancer opportunities at every stage of chemokine function” is featured on the cover of TIPS
Last November, Dr. Natalia Ortiz, Martijn Bemelmans (MSc), and Prof. Laura Heitman published a review in Trends in Pharmacological Sciences (TIPS) on targeting the chemokine system in cancer (https://doi.org/10.1016/j.tips.2021.08.001). The review was written in collaboration with Prof. Tracy Handel…
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AMPK activation as host-directed therapy to improve tuberculosis treatment: Computational characterization and prediction of intracellular pharmacology
Rob van Wijk (LACDR, Leiden University) and Robin van den Biggelaar (LUCID, LUMC) have been awarded a €10,000 euro KIEM grant from Leiden University to start an interdisciplinary collaboration to investigate the potential of AMPK activation as an adjunctive therapy to enhance tuberculosis treatment.
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Bart Custers comments on Telegram’s catalogue of crimes
Instant messaging app Telegram is not faring well in the news – the reason being the illicit activities occurring on the platform. Professor Bart Custers helped Dutch current affairs programme ‘EenVandaag’ respond to questions about the platform.
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Maaike van der Lee wins the national PhD competition 2021 at the FIGON Dutch Medicine Days
We are congratulating Maaike van der Lee, PhD candidate at LUMC-KFT, for winning the national PhD competition 2021 at the FIGON Dutch Medicine Days. During this national competition, 8 researchers from the major university cities in the Netherlands present their work in the field of innovative medicine…
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Will you be our new Research Theme Leader?
Research
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Looking at toxicodynamic variation in the human population to address chemical safety
The European Food Safety Authority (EFSA) has awarded a €1.6M contract to an LACDR-led consortium to assess how sensitivity to toxicity caused by chemicals varies among individual people. Currently these toxicodynamic differences are an unknown source of uncertainty when carrying out risk assessment…
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Vincent Delhomme successfully defends his PhD on the regulation of lifestyle risks in EU law
On Friday 2 June 2023, Vincent Delhomme, Assistant professor at the Europe Institute at Leiden Law School, successfully defended his PhD thesis entitled : ‘Regulating lifestyle risks in EU law: Promoting health in a diverse market’.
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In memoriam Hans Junginger
On 25 May 2024, our much-loved former colleague prof.dr.dr.h.c.mult Hans E. Junginger passed away.
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Natalia Ortiz – Winner of the 2019 - 2020 KNCV Medicinal Chemistry & Chemical Biology thesis prize
Natalia Ortiz (Division of Drug Discovery and Safety) has been awarded the 2019-2020 PhD-thesis prize by the Division of Medicinal Chemistry & Chemical Biology, from the Royal Netherlands Chemical Society (KNCV-MCCB). The KNCV-MCCB thesis prize is a biannual award which is granted to the best PhD thesis…
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These eleven Leiden Science researchers are among the most highly cited
Eleven researchers of the Faculty of Science are on the 2021 Highly Cited Researchers list of Clarivate Analytics. Only 0.1 per cent of researchers are included in this list, literally making them one in a thousand.
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Meet the four Leiden participants in the Europaeum Scholars Programme
Four PhD candidates from Leiden University started the two-year Europaeum Scholars Programme this month. They have now completed the first week of the programme. How was it and what do they expect from this programme?
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Veni grants for 22 researchers from Leiden University
An impressive 22 research projects by Leiden researchers have been awarded Veni funding from the Dutch Research Council (NWO).
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Veni grants for 18 Leiden researchers
Eighteen researchers from Leiden University have been awarded a Veni grant by the Dutch Research Council (NWO). This grant gives promising young researchers the opportunity to develop their ideas for a period of three years.
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The Erasmus+ grant opens doors
What is it like to participate in the Erasmus+ grant programme as a Master's student from Ukraine? Yevhenii Radchenko did an eight-month internship at Leiden University in 2018. Soon after, he returned as a PhD candidate. 'You have little to lose, but a lot to gain.'
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Maureen Rutten - van Mölken: 'Investeren in innovaties die de meeste gezondheidswinst opleveren'
Digitale medische technologie kan een belangrijke bijdrage leveren aan betaalbare zorg en het oplossen van het tekort aan zorgpersoneel. Maar hoe weet je of een innovatie daadwerkelijk waarde toevoegt aan het zorgsysteem?
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Leiden University & Elsevier Symposium on AI and Academic Publishing
Artificial Intelligence is likely to have far-reaching consequences for all actors in the realm of academic publishing, including authors, editors, researchers, and readers. This symposium aims to foster the conversation about the various ways in which we evaluate, enrich, and disseminate academic knowledge,…
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FGGA 's Follow-up Strategy Plan 2026–2030: How are things going? (Part 6)
As you know, the faculty is working on a new follow-up strategy with six themes. Each theme now has its own writing team. Every week we speak with one of these teams about their work, and share the highlights. On this page you can find the current article and an overview of all articles on the follow-up…
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A quick call with Andrei Poama on developing GenAI tools for fair formative feedback
If there's one thing that students should get from their teachers, it’s good feedback, says assistant professor Andrei Poama. ‘But we need to do it in a more fair way.’ Together with a team of experts on educational sciences, he is working on a project that develops GenAI applications that teachers…
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Valentina Carraro on peer review in financial integrity matters
On 25 February 2021, the UN High Level Panel on International Financial Accountability, Transparency and Integrity for Achieving the 2030 Agenda (FACTI panel) has adopted its final report, to which Valentina Carraro (GTGC) and Hortense Jongen (VU Amsterdam) have contributed by writing a background paper…
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Researcher Fachrizal Afandi’s coronavirus year: 'I spoke at over 30 webinars'
In mid-March 2020, the global coronavirus outbreak changed everything in the Netherlands. Staying at home as much as possible and the 1.5 metre rule became the standard. One year on, we reflect on the past year with four Leiden Law School ‘insiders’. What kind of year did they have? And what are their…
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ISSC is starting the implementation of Windows 11 at Faculty of Science
ICT
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How should the next Dutch government approach national defence?
What defence strategy should the Dutch government adopt for the next four years? Our experts advise investing in social resilience, strengthening ‘soft power’ and integrating defence awareness into education.
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eLaw Research Colloquium 2021; 'Law Gone Digital'
On Friday 10 December 2021, the Center for Law and Digital Technologies (eLaw) of the Leiden Law School, hosted its annual Research Colloquium exploring the theme 'Law Gone Digital'. The event gathered presentations by eLaw PhD candidates and professors on a wide range of topics at the interface of…
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‘Our future depends on funding for education research’
Higher education research improves the quality of education. And these investments more than pay for themselves in terms of well-being and prosperity. This is what Professor of Education Science Roeland van der Rijst will say in his inaugural lecture.
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Organising a sustainable academic event at Archaeology: ‘You will be surprised how many people actually enjoy it’
At Leiden University many staff members and students value making sustainable and responsible choices in their personal lives. Making these choices in our professional lives may feel a bit more complicated. But is that feeling justified? Archaeologists Gerrit Dusseldorp and Roos van Oosten share their…
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Alternative Humanities Campus in Leiden city centre
Leiden University and the Municipality of Leiden will develop new plans for an alternative Humanities Campus in the city centre. This means they will not proceed with the compulsory purchase of the De Doelen housing complex to facilitate the construction of the new Humanities Campus. The plans to demolish…
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Leiden Revisited: terug in de collegebanken!
Tijdens Leiden Revisited kregen alumni van de Rechtenfaculteit de mogelijkheid om zich weer even echt student te voelen. Dit jaar vond het evenement namelijk plaats in de (oude) vertrouwde collegebanken van het Kamerlingh Onnes Gebouw.
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New ‘university centre’ to be created in former Hudson’s Bay building in downtown The Hague
Leiden University, together with the Open University and Universities of the Netherlands, will take up residence in the Spui building at Grote Marktstraat 48-50/Spui 3 in downtown The Hague from 2025. The partners signed the leases on 7 November.
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Construction of alternative Humanities Campus is feasible
Leiden University can build an alternative Humanities Campus on its own available land at the current location in the city. This is the conclusion of a feasibility study and is what the mayor and aldermen of Leiden write in a letter to the city council.
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LUC The Hague: Celebrating Class of 2020 ½ and 2021
Last Friday, Leiden University College The Hague (LUC) celebrated the graduation of the Class of 2020 ½ and 2021. The 186 students received their Bachelor of Arts or Bachelor of Science degree’s in LUC’s interdisciplinary honours programme Liberal Arts & Sciences: Global Challenges. Under the silver-…