How can efficient chemical synthesis and clinical microbiology be combined to identify new antibiotics against Clostridioides difficile infections?

Lecture, Harold Linnartz Astrochemistry Prize lecture

'Her publications demonstrate a strong combination of science and practice’, according to the jury. Cramwinckel received the Stevens Award on 9 February 2024 in recognition of her scholarly publications and work in practice and education.

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Government leaders have been searching for words to condemn the actions of Belarus which intercepted a passenger aircraft flying from Athens to Vilnius, the capital of Lithuania, having a fighter plane divert it to Minsk.

Source: J Cheminform, Volume 6, Issue 1 (2014)

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

On 6 December 2022, the International Air Transport Association (IATA), which represents around 260 airlines in the world, released its Economic Outlook & State of the Industry, projecting that globally airlines would return to profit in 2023.

Steven Hill will be appointed as Associate Senior Policy Fellow at the Institute of Security and Global Affairs (ISGA) for a period of two years.

Promotor: J. Schaye

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Marc Stevens, PhD student of Ronald Cramer, and colleagues have found a weak spot in internet security. As a consequence of this weak spot in the infrastructure of digital certificates forged certificates can be issued that can be fully trusted by the usual web browsers. The results have been presented…

Professor Steven Truxal was invited to address the 15th European Civil Aviation Conference (ECAC) Forum of Directors General in Paris on 6 December 2022.

Steven Verburg wins the 2022 Hugo Weiland Prize for best thesis in Central European Studies; Caroline Schep and Anneke Romijnders awarded “Honorable Mentions” for their thesis work.

Friso Stevens, External PhD candidate at the Institute of Security and Global Affairs (ISGA) at Leiden University, wrote in de Volkskrant on the Chinese investment drive.

Context-based learning has been implemented in secondary chemistry education. Hans Vogelzang, PhD at ICLON, reseached whether Scrum methodology might support creating context-based lessons. Scrum appears to be beneficial to learning outcomes. Defence on 10 November.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is becoming increasingly important, and we’ve worked hard to make this happen.'

Steven Truxal joins Leiden University as Professor of Air and Space Law on 1 December 2020. Truxal holds a BA in International Affairs with concentrations in international law and economics from The George Washington University, Washington, DC (USA), an LLM in International Commercial Law with focus…

NATO not only safeguards our security and stability, but also defends Enlightenment principles, promoting prosperity, health and freedom. This is what eminent psychologist and thinker Steven Pinker argued to a packed Great Auditorium.

At the EUFEPS Meeting in Vienna, Lianne Stevens and team received the EJPS – Best Paper Award 2024.

University lecturer Steven Lauritano has been awarded a Comenius Teaching Fellow grant. Lauritano will use the grant of 50,000 euros to improve hybrid education in classes featuring particular objects.

China-watchers are still grappling with the wide-ranging implications of the Hong Kong national security law. Has Beijing really abrogated the legally-binding Sino-British Joint Declaration after just 23 of the agreed-upon 50 years?

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

PhD defence

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

The aim of this research was to develop an effective, generative, and practical approach to enhance students’ structure-property reasoning (SPR).

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

With defending his thesis ‘Applications of topology to Weyl semimetals and quantum computing’, the Leiden theoretical physicist Tom O'Brien has gained the rare 'cum laude' qualification. The freshly minted PhD has started a five year research programme on quantum algorithms for quantum chemistry, funded…

Sander van Kasteren (Professor of Molecular Immunology) makes the invisible visible. He will explain more in his inaugural lecture.

An international team of laboratory astrophysicists and astrochemical modellers has shown that glycine, the simplest amino acid and an important building block of life, can form under the harsh conditions that govern chemistry in space. The results have been published this week in Nature Astronomy and…

The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

Shell cooperates with theoretical physicists and chemists of Leiden University to research how quantum computer algorithms can help simulate complex molecules.

Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Since February 1st, 2017 Célia Fonseca Guerra is appointed as professor at the LIC with a chair in applied theoretical chemistry. She will be a member of the Theoretical Chemistry group. Her research interests are related to bioinorganic chemistry and catalysis and her appointment at the LIC will strengthen…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Promotor: Prof.dr. E. Bouwman

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

Professor Hermen Overkleeft has received the esteemed Roy L. Whistler International Award in Carbohydrate Chemistry for 2024 by the International Carbohydrate Organization. The award recognises Overkleeft’s outstanding contributions to the field of carbohydrate chemistry and biochemistry.