441 search results for “single molecule biophysics” in the Student website
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Maximilian WichertFaculty of Science
m.wichert@lic.leidenuniv.nl | +31 71 527 1242
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‘Ultimately, the goal is to develop antibiotics for tuberculosis with a lower risk of resistance’
Tuberculosis stands as one of the most lethal infectious diseases worldwide. A significant challenge in combatting tuberculosis lies in the emergence of antibiotic resistance triggered by genetic alterations, commonly known as mutations. These mutations can diminish the responsiveness to antibiotics,…
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Pregnancy and parenthood
Are you studying whilst pregnant or combining your studies with taking care of children? You may sometimes need a little extra help and advice. Find out about the support available and who you can turn to.
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Koos BurggraafFaculty of Science
j.burggraaf@lacdr.leidenuniv.nl | +31 71 527 6211
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Joke BouwstraFaculty of Science
bouwstra@lacdr.leidenuniv.nl | +31 71 527 2727
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Honours education at Leiden University
Everything students should know about honours education at Leiden University.
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Leiden Assessors Council (LAssO)
Leiden Assessors Council (LAssO)
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Lolita DsouzaFaculty of Science
l.a.dsouza@lic.leidenuniv.nl | 071 5272727
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Suzanne AssenFaculty of Science
s.m.e.assen@lic.leidenuniv.nl | 071 5272727
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From liquid to solid: revolutionary technique uncovers disease-related changes in tiny droplets within our cells
Understanding the behaviour of tiny droplets in our cells could aid the search for new treatments. A team of Leiden researchers has developed a groundbreaking method to study how these droplets transition from liquid to solid. This change plays a role in various diseases, including neurodegenerative…
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Hunting for life’s building blocks at minus 250 degrees Celsius
James Webb life’s building blocks
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Researchers tackle antibiotic-resistant bacteria
When a bacterium becomes more resistant to one antibiotic, it sometimes becomes more sensitive to another. To better understand this interaction, researchers from the Leiden Institute of Biology (IBL) and the Leiden Academic Center for Drug Research (LACDR) under supervision of Daniel Rozen and Coen…
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Thesis and papers
When writing a thesis or paper you must make good use of the insights you have gained during your lectures and studies so far. You should also refer to relevant literature and carry out your own research on the topic.
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Professor by special appointment Jeroen van Zon joins the Institute of Biology
As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…
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LACDR introduces ‘Digital Labcoat’ for Biopharmaceutical Sciences students
Learn to program, gain knowledge of AI methods, or use it in a research project at the LACDR. With the introduction of the innovative digital learning environment ‘Digital Labcoat’, Biopharmaceutical Sciences bachelor students can further develop their computational skills.
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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Gijs van der MarelFaculty of Science
marel_g@chem.leidenuniv.nl | +31 71 527 2727
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Peter ten DijkeFaculteit Geneeskunde
p.ten_dijke@lumc.nl | +31 71 526 9270
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Hendrikus TankeFaculteit Geneeskunde
h.j.tanke@lumc.nl | +31 71 526 9201
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Silvere van der MaarelFaculteit Geneeskunde
s.m.van_der_maarel@lumc.nl | +31 71 526 9480
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Akos KovácsFaculty of Science
a.t.kovacs@biology.leidenuniv.nl | 071 5274384
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Jitske van WelsenFaculty of Science
j.van.welsen@biology.leidenuniv.nl | 071 5272727
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With this algorithm, new medicines can be found more quickly
Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…
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Can Parkinson's be stopped by unravelling protein fibres? Anne Wentink finds out with a Vidi grant from NWO
In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…
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Making the invisible visible with ‘click chemistry’
Sander van Kasteren (Professor of Molecular Immunology) makes the invisible visible. He will explain more in his inaugural lecture.
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
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FAQ
Do you have a question concerning the Bachelor Honours Classes (BHC’s)? You can find the answers to the most Frequently Asked Questions below.
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Smart programming for the quantum computer that does not exist yet
Designing innovative algorithms, thinking outside the box, and brainstorming over coffee with his colleagues — this is what physicist Stefano Polla enjoys most. His success shines through in his nomination for the C.J. Kok Jury Award 2024 for PhD thesis of the Year.
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Thesis and papers
When writing a thesis or paper you must make good use of the insights you have gained during your lectures and studies so far. You should also refer to relevant literature and carry out your own research on the topic.
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Minors
A minor allows you to develop your knowledge beyond the boundaries of your study programme, or to specialise further in your own field of study. You can follow a minor in Leiden and also in Delft or Rotterdam.
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Thesis and papers
When writing a thesis or paper you must make good use of the insights you have gained during your lectures and studies so far. You should also refer to relevant literature and carry out your own research on the topic.
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Finally solved: how the body's own marijuana spreads through the brain
Since its discovery thirty years ago, it remained a mystery: how does the body’s own marijuana move between nerve cells in the brain? Mario van der Stelt and his research group have now uncovered the answer. This insight could aid the development of new treatments for pain and neurological disorders…
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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In memoriam Harold V.J. Linnartz 1965 – 2023: Unlocking the Chemistry of the Heavens
With great sadness we share the news that Prof. Harold Linnartz passed away suddenly and unexpectedly on Sunday 31 December 2023. We are all in shock, and our thoughts are with his wife and children, other family, and friends. Harold was at the heart of our institute, as a researcher, as a supervisor,…
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From collagen to canvas: interactive artwork brings the world between our cells to life
What’s really happening in the space between the cells in your body? With the Collagen Canvas project, students from Leiden University invite you to explore this question by blending science with art. This interactive artwork immerses you in the dynamics of the extracellular matrix—the invisible structure…
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Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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How to hijack natural destruction in cells: ‘We need to understand it through and through’
Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…
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From bachelor student to entrepreneur: card game about elementary particles an unexpected hit
bachelorstudent Serafine Beugelink ontwikkelt kaartspel over elementaire deeltjes en deeltjesfysica. Ze zet succescol haar eigen bedrijf op.
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A smarter way to search for antibiotics
Bacteria carry countless hidden treasures in their DNA: fragments that could hold the key to new medicines. But how do you pick out the most promising ones from millions of options? ‘Look at the switches that turn genes on and off,’ says molecular biologist Gilles van Wezel.
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Webb detects icy ingredients for making potential habitable worlds
An international team of astronomers, led by Will Rocha of Leiden Observatory, using the NASA/ESA/CSA James Webb Space Telescope have discovered that the key ingredients for making potentially habitable worlds are present in early-stage protostars, where planets have not yet formed.
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This is how physicists use light to build complex structures
Petr Steindl works on quantum dots in microcavities for his PhD research. He manipulates single-photons to create complex structures of light. Applications could include quantum communication and gates for quantum computers.
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Planet-forming discs around young low-mass star differs fundamentally from one around sun-like star
Using the James Webb Space Telescope, an international team of researchers, including Leiden Professor of Molecular Astrophysics Ewine van Dishoeck, has discovered a palette of hydrocarbons in a planet-forming disc around a young, low-mass star. The results confirm that discs around very lightweight…
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Leiden-developed drug candidate ready for final clinical trial phase
Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.
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Huub de GrootFaculty of Science
h.j.m.de.groot@lic.leidenuniv.nl | 071 5274539
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Dag van de duurzaamheid: Launch Billiecup
Op de dag van de duurzaamheid van 10 oktober startte de 'Billiecup' pre-pilot op de Faculteit der Rechtsgeleerdheid. Aanwezig waren 'plastic soup surfer' Merijn Tinga, Bart Hemmes van het Leiden University Green Office (LUGO) en Esther Kentin, docent bij instituut Metajuridica & projectleider Leiden…
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Improving nature’s antibiotic
'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…
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The Nobel Prize in Chemistry went to an AI model (and rightly so)
Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…
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Chemotherapy without side effects? It’s possible, with light
Nausea, neurologic pain and hair loss: some of the severe side effects of chemotherapy. Not necessary, biochemist Liyan Zhang showed. Together with Leiden biologists and others, she achieved great results with a drug that is only active in combination with light. Zhang will defend her PhD on 4 July.