Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Leiden University will appoint Dr Anne-Laura van Harmelen as Professor of Brain, Security and Resilience at the Institute of Education and Child Studies with effect from 1 September 2020. She will focus on the brain in relation to the development of transgressive behaviour and its prevention and tre…

Hoping to learn something about the human brain, Leiden researchers are creating a setup to shoot single photons, particles of light, into someone’s eye. ‘The eye is a passageway to the brain.’

May 12 is Mother's Day in many countries. Becoming a mother is no mean feat: brain scientist Elseline Hoekzema has shown that a woman's brain changes drastically during pregnancy. She explained how in TV show De Kennis van Nu.

Maaike Kempes believes more attention should be paid to non-congenital brain injuries in suspects. This may partly explain their criminal behaviour.

Brain scanners have radically changed neurolinguistics. They are increasing our understanding of how the brain processes language. Professor Niels Schiller has produced a standard work on this.

The brain structure of young people with conduct disorder differs significantly from that of their typically developing peers. This is the conclusion of an international study that analysed more than two thousand MRI scans, recently published in The Lancet Psychiatry. Dr Moji Aghajani, one of the principal…

Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.

The Leiden Institute for Brain and Cognition (LIBC) is concentrating increasingly on research into the role of the brain in language development. The institute has now set up the LIBC Language website that brings together all the information on this research.

What happens in the brains of people with psychiatric illnesses? With a €23.23 million gravity grant, scientists from different fields will search for biological causes over the next decade. ‘By joining forces, we hope to improve diagnosis and treatment for patients with these diseases.’

Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.

A unique multicenter study, including about 3,500 youth between 10 and 25 years old from across the globe, shows that artificial intelligence - specifically machine learning - is able to identify individuals with anxiety disorders based on their unique brain structure.

It may seem as though adolescents do as they please, but they are more sensitive to their parents’ opinions than they would appear. The adolescent brain reacts strongly to parental criticism or praise. These are the results of a study by an interdisciplinary research group of psychologists and neuroscientists…

Physicists Lucia Bossoni and Martina Huber have been awarded an NWA Ideeëngenerator-grant for research into iron nanoparticles in the brain. These nanoparticles may be linked to air pollution and Alzheimer's disease.

Researchers at the Universities of Amsterdam (Uva) and Leiden together with the Netherlands Cancer Institute and Oncode Institute have received a €10,6 million ERC Synergy Grant to develop innovative therapeutic approaches to target glioblastoma. This is a deadly primary brain tumour for which no curing…

During adolescence, some young people have stable best-friend relationships, while others change best friends frequently. Developmental psychologist Lisa Schreuders has studied the brains of young adolescents: ‘It seems that friendships in your early years can have consequences for your friendships…

Why do some people with adverse childhood experiences develop mental health conditions whereas others do not? A Leiden research project is looking for volunteers aged between 18 and 24 to help us understand more about human resilience.

Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.

The way in which written language is processed in the brain is a hot topic in cognitive research. Cognitive psychologist Rinus Verdonschot studied a Japanese script in which a single character can have up to three possible pronunciations. He discovered that all three are simultaneously activated in…

Parents appear to be extremely sensitive to feedback they receive about their child. Just how sensitive depends on the (‘rose-tinted’) glasses through which they look at their child. All this can be seen in the brain. Neuroscientist Lisanne van Houtum and her Leiden colleagues published on this issue…

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.

Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience.

Within 20 years, intelligent machines will play a major role in society. ‘Selfdriving cars will be 90% safer than human-driven cars and will change transportation globally,’ says artificial intelligence scientist Bart Selman of Cornell University. He gave the first Ada Lovelace lecture of the Leiden…

'With this artwork, I want to give the audience a glance into my overstimulated brain and that of other people with autism', says Jasmijn den Hoed. The Faculty of Social and Behavioural Sciences is exhibiting her artwork 'Overstimulated' in the restaurant near the blue wall during Autism Week 25 March…

With the help of software that mimics a human brain, ESA’s Gaia satellite spotted six stars zipping at high speed from the centre of our Galaxy to its outskirts. This could provide key information about some of the most obscure regions of the Milky Way.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

We are all at home in familiar surroundings. Not only is this boring but it can also have a negative influence on our learning, explains cognitive neuropsychologist Judith Schomaker. ‘Discovering new environments gets our brain learning and remembering. We are now missing this stimulus.’

The Pilgrims to America exhibition at Museum De Lakenhal inspires reflection. How far do you go in the quest for freedom? It focuses on the Pilgrims’ relationship with the University and which knowledge they took with them from Leiden.

Dutch newspaper NRC contacted four Dutch universities regarding the brain drain in the field of Artificial Intelligence (AI) that is going on in the Netherlands.

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Just imagine: you see someone being treated unfairly. Do you find it more rewarding to help the victim or punish the perpetrator? Research by Leiden psychologist Mirre Stallen indicates that punishing is more rewarding. Publication in JNeurosci.

ACPA’s PhD candidate and composer/flutist Ned McGowan will give a lecture at Café Chercher on March 27 called Speed in Music, Brain and Body.

Max van Duijn, Assistant Professor at the Leiden Institute of Advanced Computer Science (LIACS), has been awarded a Veni grant for his research into children's empathy. The ability to empathise can be studied by telling stories. This process, known as 'Theory of Mind' or ‘mindreading’, can provide important…

It is true that girls perform better at school than boys, but this is not due to differences in brain development. This is the conclusion psychobiologist Lara Wierenga draws from a recent study. Publication in the Journal of Cognitive Neuroscience.

During ExpeditionNEXT in Middelburg, NeurolabNL youth, together with researchers from Leiden University and Erasmus University, handed over a unique research agenda to NWO Chairman Marcel Levi. In it, young people share what they would most like to learn about themselves and the brain.

Deep-brain stimulation (DBS) is the most promising surgical treatment for movement and neuropsychiatric disorders, but is accompanied by unwanted side effects. Birte Forstmann, professor by special appointment, has been awarded a ERC Proof of Concept Grant to create an atlas of the human deep brain…

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

BRAIN Biotech and the Leiden University will jointly develop an Aspergillus based production strain with high yield and thus contribute to a bio-based circular economy. The cooperation is based on BRAIN´s molecular tool BEC.

Neuroscientist Elseline Hoekzema receives a large European grant from the European Research Council (ERC). This ERC starting grant for promising young researchers allows her to investigate the effects of pregnancy on the brain in detail.

It’s not a regular occurrence at Leiden University: two professors giving their inaugural lecture on the same day. Berna Güroğlu and Ellen de Bruijn specialise in related disciplines: they both research the influence of social context on processes in the brain – Güroğlu in adolescents and De Bruijn…

When we hear the word ‘bird house’, do we process it as a whole or does our brain see it as ‘bird’ and ‘house’? PhD student Jiaqi Wang explored this for speakers of Mandarin Chinese.