This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…

Promotor: Prof.dr. J. Kuiper

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

Source: Mediators Inflamm (2014)

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cardiovascular disease is the leading cause of death worldwide.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

Key publications of the Analytical BioSciences and Metabolomics group

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

The WARN project seeks to understand why certain warnings fail to reach and impact decision makers in time to avert crisis.

International Coalitions for Peace in the Era of Decolonization, 1918-1970

Matthew Hoye argues for a regulatory analytical perspective to look at the sanctioning of Afghanistan.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

On 19 September 2019, Lynette Janssen defended her thesis 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. The doctoral research was supervised by Prof.mr. W.A.K. Rank and prof. M. Haentjens.

Promotor: G.R. de Snoo

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

In this study I explore literary structures of identity-formation in the works of assimilated/acculturated Jewish writers: Kafka’s novella “The Metamorphosis” (“Die Verwandlung”, 1912) and David Vogel’s Hebrew novel Married Life. 1929).

How can innovation help or hinder public procurement processes?

Andrew Littlejohn published the article 'Ruins for the future: Critical allegory and disaster governance in post-tsunami Japan' in American Ethnologist about the ruins left by Japan's 2011 tsunami.

The future of Europe as a community of democratic states is deeply uncertain. The European Union, founded to promote ‘ever closer’ integration, aims nominally for peaceful, prosperous cooperation. But this ideal has been battered by a series of bruising crises, and now by war.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

On December 11th, Andreea Geambasu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Andreea on this great result.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

November 2020 saw the publication of the book ‘Financial Collateral; Law and Practice’. This book was published by Oxford University Press, and edited and authored by Professor Matthias Haentjens. Other authors who contributed to the book are Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

This paper addresses the gap that explores how agencies might allocate their personnel so as to maximise performance with the personnel they have.

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Overkleeft

Discover the connection between skateboarding and sensory ethnography in 32 of The Routledge International Handbook of Sensory Ethnography as part of the Multi-modal sensory ethnography.

Desinging Your Life helps students design their life path and face the future with confidence.